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Shaping the future of transplantation at CEOT
AST's Cutting Edge of Transplantation (CEOT) meeting took place in Chandler, Ariz., last week from Feb. 13-15. This year's subject was how to optimize long term graft survival. The meeting successfully created a highly interactive format for leading experts and engaged attendees to tackle the problem. Indeed, it repeated the success of last year's meeting on the role and management of anti-donor antibodies in transplantation outcomes. Several major themes emerged during this meeting that will be part of transplantation's future, such as how to conduct the next generation of clinical trials, the obstacles to the field created by lack of agreement on the mechanism driving long term graft injury and loss, the huge potential of a new class of drugs that can prevent tissue injury via modulating mechanisms of cell necrosis, and the need for us to critically examine and advance our partnerships with Pharma. The program included more than 30 interactive talks in addition to rapid-fire abstract presentations and speed round-table discussions.

Despite the weather affecting many people in the northeast and southeast, we had a great turnout and the stellar presentations stimulated excellent discussion. Presentations will be available on the AST website in mid-March.

Thank you to all those that attended and supported CEOT to help make it such a success! Save the date for next year's CEOT meeting — Feb. 5-7, 2015!

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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE

One week left to pay it forward and enter for a chance to win!
There is just one week left to talk to your colleagues about the benefits of AST membership that you find most valuable! Encourage your colleagues to join today and you'll both strengthen the transplant community while helping each other grow both personally and professionally!

For each new member that you recruit, your name will be entered to win one of three prizes, including an iPad and AST Bucks! Additionally, you'll receive recognition for your efforts at the 2014 World Transplant Congress (WTC), on the AST website and in the AST eNews. Encourage your colleagues to complete a membership application by Friday, Feb. 28, so that they may register for the WTC at the member discounted registration rate. Click here for more information.

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High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept
American Journal of Transplantation (login required)
The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high incidence of acute rejection following renal transplantation, which led us to investigate the etiology of belatacept–resistant graft rejection.
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The National Health Council helps you put patients first
The National Health Council
The National Health Council recently launched, a website dedicated to connecting people living with chronic diseases and disabilities to resources and organizations focused on their particular needs. Given the insurance and reimbursement issues that transplant teams deal with every day, the website's resources for patients navigating the new health insurance marketplace may be particularly helpful. Learn more here.
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Time course of pathologic changes in kidney allografts of positive crossmatch HLA-incompatible transplant recipients
Transplantation (login required)
Recipients of incompatible allografts are at increased risk of graft loss. We hypothesized that analysis of sequential biopsies from these grafts could define progression of graft lesions and identify features predictive of progression.
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Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response
Kidney International (login required)
Prospective studies of unselected indication biopsies from kidney transplants, combining conventional assessment with molecular analysis, have created a new understanding of transplant disease states and their outcomes. A large-scale Genome Canada grant permitted authors to use conventional and molecular phenotypes to create a new disease classification.
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The renin-aldosterone axis in kidney transplant recipients and its association with allograft function and structure
Kidney International (login required)
The level of the renin–angiotensin–aldosterone system activity in kidney transplant recipients has not been extensively studied or serially profiled. To describe this axis and to determine its association with glomerular filtration rate change, interstitial expansion and end-stage renal disease, authors measured plasma renin activity and plasma aldosterone levels annually for five years in 153 kidney transplant recipients randomly assigned to losartan or placebo.
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Histologic phenotype on 1-year posttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants
The correlation between histopathologic phenotypes and allograft outcomes among patients desensitized for donor-specific antibody (HLA-incompatible) is unknown. Authors analyzed one-year biopsies from desensitized recipients transplanted between 1999 and 2010 and estimated graft survival for each histologic phenotype identified. Median time posttransplant for the one-year biopsy was 367 days (interquartile range 357-388 days) and median follow-up of all patients post-1-year biopsy was 42 months (interquartile range 19.5-65 months).
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Sterile leukocyturia is associated with interstitial fibrosis and tubular atrophy in kdney allograft protocol biopsies
American Journal of Transplantation (login required)
Kidney allograft interstitial fibrosis and tubular atrophy (IF/TA) is associated with a poorer renal function and outcome. In the current clinical practice, an early diagnosis can only be provided by invasive tests. We aimed to investigate the association of sterile leukocyturia with Banff criteria histological findings in kidney allograft protocol biopsies. We studied 348 allograft biopsies from two different European countries performed at 8.5+ 3.5 months after transplantation.
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Missed last week's issue? See which articles your colleagues read most.

    High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 Coinhibition and resistance to belatacept (American Journal of Transplantation (login required))
Histologic phenotype on 1-year poosttransplantation biopsy and allograft survival in HLA-incompatible kidney transplants (Transplantation)
CUSUM: New quality monitoring tools provided by the Scientific Registry of Transplant Recipients (American Journal of Transplantation)
Study: Multimodality therapy and liver transplantation for hepatocellular carcinoma (Transplantation)
Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch (Transplantation)

Don't be left behind. Click here to see what else you missed.

Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?
Xenotransplantation (login required)
Baboons have natural antibodies against pig antigens. We have investigated whether there are differences in anti-non-Gal pig antibody levels between baboons maintained under specific pathogen-free (SPF) conditions and those housed under conventional conditions (non-SPF) that might be associated with improved outcome after pig-to-baboon organ transplantation.
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Colby Horton, Vice President of Publishing, 469.420.2601
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