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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Feb. 28, 2013

 




Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts
American Journal of Transplantation (subscription required)
It has been previously reported that kidney transplants with early acute injury express transcripts indicating injury repair — the acute kidney injury signal. This study investigated the significance of this signal in transplants with other conditions, including rejection and recurrent disease. The injury signal was elevated in biopsies in many different conditions, including T cell-mediated rejection and potentially progressive diseases such as antibody-mediated rejection and glomerulonephritis. A high injury signal correlated with poor function and with inflammation in areas of fibrosis, but not with fibrosis without inflammation.
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SOCIETY NEWS


New educational activity: CMV pathway case management
AST
AST has endorsed a new free, interactive online activity, Pathways in CMV Case Management. This CME/CE activity was developed by Spire Learning and is supported by an educational grant from Genentech. Learn how to evaluate your transplant center's protocols for preventing and managing CMV disease in transplant recipients, and how to select the appropriate strategies to prevent and manage CMV disease in adult and pediatric transplant recipients. Take part in this activity today.
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Invite your colleagues to join AST
AST
Pay it forward and encourage your colleagues to join AST. Prospective members who wish to attend the 2013 American Transplant Congress (ATC) should submit a membership application by March 1. This is the last chance prospective members will have to apply for AST membership and attend the ATC at the member discounted rate. When you pay it forward you'll be entered to win an iPad or AST bucks, and you'll be recognized at ATC, on the AST website, and in the AST eNews. Your recruitment efforts help strengthen the transplantation community.
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Innovation in Surgical Retraction
Thompson Surgical Instruments, Inc. is the market leader in surgical retraction and the manufacturer of the original table mounted retractor. For more information, visit our website at thompsonsurgical.com or email us at info@thompsonsurgical.com.


Membership dues reminder
AST
If you have not yet remitted payment for your 2013 membership dues, please do so immediately to ensure that you continue to receive all of the benefits of membership with the AST, including discounted meeting registration. Your dues must be paid no later than April 1 in order to be eligible for member discounted registration rates to the American Transplant Congress in Seattle. Renewing your membership is easy. Simply log in to the AST website and click on "Renew My Membership" to pay your dues online. A confirmation email will be sent to you once your payment is processed.
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Live webinars March 6 and 13 — free to AST members
AST
Register today for either of these two live webinars; participate at the scheduled date and time or view the archives later on. "Meeting the Challenges of Resistance" airs at 1 p.m. EST on Wednesday, March 6 as part of the Timely Topics in Transplantation webinar series." A Primer on Optimizing an Organ Transplant Program's Financial Statement" airs at 2 p.m. ET on Wednesday, March 13 as part of the Business of Transplantation webinar series. Both webinars are free for AST members and available for non-members for a fee.
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Antibody mediated rejection in liver transplantation meeting March 2013 in Dallas
AST
Endorsed by AST
Antibody mediated rejection is a well known and feared entity in all solid organ transplants – except the liver. Previous studies and literature regarding liver allografts have been inconsistent, and mounting evidence has shown the pathologic potential of DSA in liver and SLKT recipients. The goal of this conference is to bring about a meeting of the minds to define AMR in liver transplantation and forge a path for future research in this burgeoning area of research. Program information is available at www.DallasAMR.com. Register today.

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  PRODUCT SHOWCASES
Astellas Pharma US, Inc.
Astellas Pharma US, Inc., a U.S. affiliate of Tokyo-based Astellas Pharma Inc., is a pharmaceutical company dedicated to changing tomorrow by improving the health of people around the world through innovative and reliable pharmaceutical products. For more information about Astellas Pharma US, Inc., please visit our Web site at www.astellas.us
WAVES by Waters Medical Systems
✓ Hypothermic preservation of a single kidney using physiologic pulsatile preservation and membrane oxygenation: a proven technology from Waters Medical Systems (more than 40 years clinical experience) ✓ Simplifies the perfusion process (provides more options to view, chart, and trend data, offers web-based remote monitoring, and a transportable design)
✓ Meets or exceeds current FDA standards and AOPO and UNOS Preservation Guidelines.
MNX: Organ Transportation
When it comes to saving lives, MNX understands organ transplant logistics. Every shipment is urgent, and every step critical. That’s why MNX offers specialty services that are tailored for organ transportation. From expedited ground service to charter flights, MNX has the proven experience and operational resources you can count on.


TRANSPLANT NEWS


Mesenchymal stem cells overexpressing c-x-c chemokine receptor type 4 improve early liver regeneration of small-for-size liver grafts
Liver Transplantation (subscription required)
Mesenchymal stem cell (MSC) therapy can prevent hepatic parenchymal cell loss and promote tissue repair. However, poor MSC engraftment is one of the primary barriers to the effectiveness of cell therapy because culture-expanded MSCs progressively down-regulate C-X-C chemokine receptor type 4 (CXCR4) expression and lose their ability to migrate toward a concentration gradient of stromal cell–derived factor 1a (SDF1a). In a recent study, researchers investigated whether a CXCR4-MSC infusion could protect hepatocytes and stimulate regeneration in 50 percent reduced size liver transplantation.
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Kidney transplant chains boost benefit of nondirected donors
Renal & Urology News
Kidney transplant chains augment the benefit of nondirected donors, according to investigators. In a study, researchers found that altruistic nondirected donors (NDDs) triggered almost five transplants on average, and more if the NDD was blood type O. Dr. Marc L. Melcher, Ph.D., of Stanford University in Palo Alto, Calif., and colleagues reviewed a large multicenter living donor-recipient database that contained information about donor-recipient pairs from 57 U.S. transplant centers.
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Unrecognized intrahepatic cholangiocarcinoma: Analysis of 993 adult cirrhotic liver explants
Clinical Transplantation (subscription required)
Liver cirrhosis is a recognized risk factor for intrahepatic cholangiocarcinoma (I-CCa). Small I-CCa nodules might be undiagnosed or misdiagnosed as hepatocellular carcinoma (HCC) in the context of liver cirrhosis. The aim of a recent study was to determine the prevalence and clinical impact of undetected I-CCa in liver explants of adult cirrhotic patients undergoing liver transplantation (LT). From December 1985 to November 2008, a first LT was performed in 993 adult cirrhotic patients in three French academic Hospitals. All liver explants were analyzed for the presence of nodules.
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Molecular analysis of renal allograft biopsies — more than a nice toy for researchers?
American Journal of Transplantation (subscription required)
This editorial discuss two papers on molecular diagnosis of kidney transplant injury as an alternative to standard histopathological analysis, highlighting the broad range of opportunities as well as remaining needs influencing the adoption of these techniques into routine clinical practice.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts (American Journal of Transplantation)
Molecular analysis of renal allograft biopsies — more than a nice toy for researchers? (American Journal of Transplantation)
Kidney transplant chains boost benefit of nondirected donors (Renal & Urology News)
Study: Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism (Clinical Transplantation)
Don't be left behind. Click here to see what else you missed.


New perspectives in transplantation through intravital microscopy imaging
Current Opinion in Organ Transplantation (subscription required)
Rejection of transplanted organs is a complex and highly dynamic immune process. Two-photon laser-scanning intravital microscopy (LSIM) allows for real-time, deep tissue, high-resolution imaging in physiological conditions. The recent application of this technology to study organ rejection started to provide a clearer picture of the spatiotemporal immunological dynamics of organ rejection.
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Study: Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism
Clinical Transplantation (subscription required)
Researchers investigated how cytochrome P450 (CYP) 3A5 polymorphism affects pharmacokinetics of tacrolimus and its interaction with diltiazem in Chinese kidney transplant recipients. Sixty-two CYP3A5 expressers and 58 non-expressers were, respectively, randomized to receive diltiazem supplement or not. Their pharmacokinetic profiles were acquired on 14th day, sixth month and 18th month posttransplant and compared among groups.
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The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival
Xenotransplantation (subscription required)
Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression). Subsequently, the International Xenotransplantation Association has published recommendations for entering a clinical trial. Experiments showed limitations that affected consistent achievement of long-term survival. Researchers aimed to identify these limitations and underlying causes to emphasize the translational value of this highly relevant type 1 diabetic macaque model.
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First interspecies neuron transplant means longer brain life
Examiner.com
Italian neuroscientists are the first to discover that the maximum life span of some mammalian neurons may not be limited by the maximum life span of the organism in which they originated as reported in the Feb. 25, Proceedings of the National Academy of Science. The scientists transplanted neuronal precursors from the developing mousecerebellum into the cerebellum of rat embryos, using a strain of rat that can live on average nearly twice as long as the donor mouse strain.
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Outcomes and predictive factors of pediatric kidney transplants: An analysis of the Thai transplant registry
Pediatric Transplantation (subscription required)
As universal coverage for pediatric kidney transplantation (KT) was introduced in Thailand in 2008, the number of recipients has been increasing. We evaluated predictive factors for graft failure to understand how to improve clinical outcomes in these children.
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