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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Mar. 7, 2013


Cardiac troponin T before and after kidney transplantation: Determinants and implications for posttransplant survival
American Journal of Transplantation (subscription required)
Pretransplant cardiac troponin T (cTnTpre) is a significant predictor of survival postkidney transplantation. Researchers assessed correlates of cTnT levels pre- and posttransplantation and their relationship with recipient survival. A total of 1206 adult recipients of kidney grafts between 2000 and 2010 were included.
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Webinar: Primer on Optimizing an Organ Transplant Program's Financial Statement
Register today at for a live webinar on Wednesday, March 13 at 2 p.m. ET titled: "Primer on Optimizing an Organ Transplant Program's Financial Statement." This webinar is free to AST members and available to non-members for a fee. It is part of the Business of Transplantation webinar series, a live monthly series on the second Wednesday of each month through June. Archives of past webinars are available for viewing anytime.
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UNOS Primer to Practice: Communication, education and engagement
The UNOS Primer takes place Sept. 16-17, 2013 in Richmond, Va. The Primer will offer an up close and personal learning experience with the dynamic world of transplant policy development and how it impacts the day-to-day work of transplant and organ procurement professionals. Included is a look at UNOS' structure, OPTN contract requirements, policy implementation and compliance, and more. Time will be set aside for tours of UNOS headquarters, including the Organ Center and the National Donor Memorial, as well as interactions with UNOS staff. Registration opens in mid-March. Learn more.
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Innovation in Surgical Retraction
Thompson Surgical Instruments, Inc. is the market leader in surgical retraction and the manufacturer of the original table mounted retractor. For more information, visit our website at or email us at

Continue the dialogue and pay it forward
There is still time to "Pay it Forward" and encourage your colleagues to join AST, the home for all transplant professionals. Your recruitment efforts will help strengthen the transplantation community. When you "Pay it Forward" you'll be entered to win an iPad with retina display or AST bucks, and you'll be recognized at the ATC conference, on the AST website and in the AST eNews. The deadline to submit applications is April 1. Learn more.
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NTPR relocates to Gift of Life Institute
The National Transplantation Pregnancy Registry (NTPR) announces its new home at Gift of Life Institute, the research branch of the Transplant Foundation. The NTPR is an active ongoing research study that collects information about pregnancies in female solid organ recipients and those fathered by male recipients. The NTPR encourages all transplant centers to participate. Please feel free to contact them if you would like to receive display material for your office or NTPR reports. Contact information for Dr. Vincent Armenti, Principal Investigator, and the NTPR team can be found here.
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Older circulatory-death donor kidneys acceptable for transplant
Renal & Urology News
Kidneys from non-heart-beating donors (NHBD) older than 60 years are associated with a similar risk of graft loss as kidneys from brain-death donors (BDD) in the same age group, according to a new study by British investigators. In addition, a cold ischemia time of more than 24 hours predicts worse graft survival of BDD kidneys compared with NHBD kidneys. The government-funded study of 6,490 kidney transplants also confirmed that donor age over 60 years compared to age under 40 years is associated with a significantly increased risk of graft loss for both BDD and NHBD kidneys, a research team led by Dr. Dominic Summers of Addenbrooke's Hospital in Cambridge, U.K., reported in The Lancet.
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Astellas Pharma US, Inc.
Astellas Pharma US, Inc., a U.S. affiliate of Tokyo-based Astellas Pharma Inc., is a pharmaceutical company dedicated to changing tomorrow by improving the health of people around the world through innovative and reliable pharmaceutical products. For more information about Astellas Pharma US, Inc., please visit our Web site at
WAVES by Waters Medical Systems
✓ Hypothermic preservation of a single kidney using physiologic pulsatile preservation and membrane oxygenation: a proven technology from Waters Medical Systems (more than 40 years clinical experience) ✓ Simplifies the perfusion process (provides more options to view, chart, and trend data, offers web-based remote monitoring, and a transportable design)
✓ Meets or exceeds current FDA standards and AOPO and UNOS Preservation Guidelines.
MNX: Organ Transportation
When it comes to saving lives, MNX understands organ transplant logistics. Every shipment is urgent, and every step critical. That’s why MNX offers specialty services that are tailored for organ transportation. From expedited ground service to charter flights, MNX has the proven experience and operational resources you can count on.

Standardizing skin biopsy sampling to assess rejection in vascularized composite allotransplantation
Clinical Transplantation (subscription required)
More than 70 hands and 20 faces have been transplanted during the past 13 years, which have shown good to excellent functional and aesthetic outcomes. However, (skin) rejection episodes complicate the post-operative courses of hand and face transplant recipients and are still a major obstacle to overcome after reconstructive allotransplantation. As more and more centers plan to implement a vascularized composite allotransplantation (VCA) program, they further develop guidelines and recommendations on collection and processing of skin biopsies from hand and face allograft recipients.
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Anatomic fitting of total artificial hearts for in vivo evaluation
Artificial Organs
Successful anatomic fitting of a total artificial heart (TAH) is vital to achieve optimal pump hemodynamics after device implantation. Although many anatomic fitting studies have been completed in humans prior to clinical trials, few reports exist that detail the experience in animals for in vivo device evaluation. Optimal hemodynamics are crucial throughout the in vivo phase to direct design iterations and ultimately validate device performance prior to pivotal human trials.
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Importance of the temporary portocaval shunt during adult living donor liver transplantation
Liver Transplantation (subscription required)
Adult living donor liver transplantation (aLDLT) is associated with surgical risks for the donor and with the possibility of small-for-size syndrome (SFSS) for the recipient, with both events being of great importance. An excessively small liver graft entails a relative increase in the portal blood flow during reperfusion, and this factor predisposes the recipient to an increased risk of SFSS in the postoperative period, although other causes related to recipient, graft and technical factors have also been reported.
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Missed viral surveillance testing visits associate with full blown viral diseases in children receiving kidney transplants
Pediatric Transplantation (subscription required)
Surveillance testing for major viral infections such as CMV, EBV and BKV early in their natural history course may allow for early intervention and prevention of FBVD, but the testing is expensive and optimal interval/frequency are uncertain. Researchers initiated routine monthly viral surveillance for CMV, EBV and BKV in July 2008 for the first 12 months posttransplant. In a small group of contemporaneous patients on identical immunosuppression, those patients who missed regular viral surveillance were more likely to develop FBVD.
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Missed last week's issue? See which articles your colleagues read most.

    Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts (American Journal of Transplantation)
Molecular analysis of renal allograft biopsies — more than a nice toy for researchers? (American Journal of Transplantation)
Kidney transplant chains boost benefit of nondirected donors (Renal & Urology News)
Study: Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism (Clinical Transplantation)
Don't be left behind. Click here to see what else you missed.

Preoperative acute renal failure, renal replacement therapy increased liver transplant mortality risk
Liver transplant recipients with preoperative acute renal failure who received renal replacement therapy were at greater risk for death than patients with preoperative acute-on-chronic renal failure in a recent study. In a post-hoc analysis, researchers evaluated mortality rates in a cohort of 135 patients aged older than 16 years who underwent liver transplantation at a medical facility between January 2003 and December 2008.
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Clinical significance of quantitative cytomegalovirus detection in bronchoalveolar lavage fluid in lung transplant recipients
Transplant Infectious Disease
Cytomegalovirus (CMV) is an important pathogen after lung transplant (LTx) and may be associated with bronchiolitis obliterans syndrome (BOS). In a retrospective survey, researchers assessed the outcome of LTx patients with CMV DNA-positive bronchoalveolar lavage (BAL) during surveillance. Detection of CMV-positive BAL after the sixth month appears common, but did not correlate with BOS-free survival after LTx in this study. An increased risk of developing blood antigenemia was observed in patients with positive CMV PCR in BAL, warranting close follow-up.
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