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Study: Colonization with small conidia Aspergillus species is associated with bronchiolitis obliterans syndrome
American Journal of Transplantation (subscription required)
Aspergillus colonization after lung transplantation may increase the risk for bronchiolitis obliterans syndrome (BOS), a disease of small airways. Researchers hypothesized that colonization with small conidia Aspergillus species would be associated with a greater risk of BOS, based upon an increased likelihood of deposition in small airways. Although other virulence traits besides conidia size may be important, it has been demonstrated in two large independent cohorts that colonization with small conidia Aspergillus species increases the risk of BOS and death.
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Transplant Nephrology Core Curriculum: Online course for individuals or groups
This online program, available for purchase at, is based on the American Board of Internal Medicine's nephrology certification exam blueprint and is designed to help you prepare for and maintain board certification, or simply learn more about kidney transplantation.

Purchase the course and get immediate access to nine hours of presentations from outstanding speakers in the field, plus a self-administered exam to help you assess your knowledge in the discipline. We offer a $300 individual subscription or a $1,000 group subscription for up to five people. Continuing education credit for physicians is also available for an additional small fee (up to nine AMA PRA Category 1 Credits). This program is co-sponsored by the American Society of Nephrology and the American Society of Transplantation.

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Innovation in Surgical Retraction

Thompson Surgical Instruments, Inc. is the market leader in surgical retraction and the manufacturer of the original table mounted retractor. For more information, visit our website at or email us at

Online Journal Club March 26, 2013: Hosted by Transplant Pharmacy COP
AST members and non-members are invited to a free online journal club on Tuesday, March 26 at 3 p.m. ET. The article to be discussed is the "Effect of Corticosteroid Withdrawal on Tacrolimus and Mycophenolate Mofetil Exposure in a Randomized Multicenter Study" and author Dr. Fuad Shihab will participate in the discussion led by facilitator Lisa McDevitt-Potter, PharmD. Pre-registration is recommended to secure your place.
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Important ATC information
Membership dues must be paid prior to April 1 to receive the member discounted registration rate to attend the 2013 ATC May 18-22 in Seattle. The member discounted rate will not be available if membership dues are submitted after April 1, and members who pay dues after April 1 will be required to register at the non-member rate. Additionally, members will not be able to pay membership dues on-site and then register on-site at the member discounted rate. Visit to register for the ATC. If you are uncertain whether your dues have been paid, or you have any other questions, please contact the AST office at
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Astellas Pharma US, Inc.

Astellas Pharma US, Inc., a U.S. affiliate of Tokyo-based Astellas Pharma Inc., is a pharmaceutical company dedicated to changing tomorrow by improving the health of people around the world through innovative and reliable pharmaceutical products. For more information about Astellas Pharma US, Inc., please visit our Web site at

LIFECODES is introducing its new HLA-SSO kits. The new kit includes a validated, high-performance enzyme for improved reliability and performance with the continued ease of no centrifugation or wash steps; providing accurate, clear and easy to interpret results.
WAVES by Waters Medical Systems

✓ Hypothermic preservation of a single kidney using physiologic pulsatile preservation and membrane oxygenation: a proven technology from Waters Medical Systems (more than 40 years clinical experience) ✓ Simplifies the perfusion process (provides more options to view, chart, and trend data, offers web-based remote monitoring, and a transportable design)
✓ Meets or exceeds current FDA standards and AOPO and UNOS Preservation Guidelines.


Vaccination in solid organ transplantation
American Journal of Transplantation (subscription required)
Transplant candidates and recipients are at an increased risk of infectious complications of vaccine-preventable diseases. Every effort should be made to ensure that transplant candidates, their household members and healthcare workers have completed the full complement of recommended vaccinations prior to transplantation. Since the response to many vaccines is diminished in organ failure, transplant candidates should be immunized early in the course of their disease.
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Missed last week's issue? See which articles your colleagues read most.

    Cardiac troponin T before and after kidney transplantation: Determinants and implications for posttransplant survival (American Journal of Transplantation) )
Clinical significance of quantitative cytomegalovirus detection in bronchoalveolar lavage fluid in lung transplant recipients (Transplant Infectious Disease)
Preoperative acute renal failure, renal replacement therapy increased liver transplant mortality risk (Healio)
Standardizing skin biopsy sampling to assess rejection in vascularized composite allotransplantation (Clinical Transplantation)
Don't be left behind. Click here to see what else you missed.

Vital signs: Carbapenem-resistant enterobacteriaceae
Enterobacteriaceae are a family of bacteria that commonly cause infections in healthcare settings as well as in the community. Among Enterobacteriaceae, resistance to broad-spectrum carbapenem antimicrobials has been uncommon. Over the past decade, however, carbapenem-resistant Enterobacteriaceae (CRE) have been recognized in healthcare settings as a cause of difficult-to-treat infections associated with high mortality.
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Contraceptive options for women with a history of solid-organ transplantation
Women of reproductive age who have received a solid-organ transplant are at risk for unplanned pregnancy. Fertility can return as soon as one month after transplantation, and the baseline unplanned pregnancy rate in the United States is approximately 50 percent. Pregnancy, although not absolutely contraindicated in this population, carries risk greater than the general population and should be timed with regard to medication regimen and organ function.
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Exclusively Focused Transplant Pharmacy Therapeutics
Transplant IV Biologics and Oral Immunosuppressives specializing in Desensitization and AMR Treatment and Prevention. MORE
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact James DeBois at 469-420-2618.

Risk of waitlist mortality in patients with primary sclerosing cholangitis and bacterial cholangitis
Liver Transplantation (subscription required)
Patients with primary sclerosing cholangitis (PSC) are at increased risk for bacterial cholangitis because of biliary strictures and bile stasis. A subset of PSC patients suffer from repeated episodes of bacterial cholangitis, which can lead to frequent hospitalizations and impaired quality of life. Although waitlist candidates with PSC and bacterial cholangitis frequently receive exception points and/or are referred for living donor transplantation, the impact of bacterial cholangitis on waitlist mortality is unknown.
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Cancer risk with alemtuzumab following kidney transplantation
Clinical Transplantation
Alemtuzumab has been employed for induction therapy in kidney transplantation with low rates of acute rejection and excellent graft and patient survival. Antibody induction therapy has been linked to increased vulnerability to cancer. Data regarding malignancy rates with alemtuzumab are limited. Researchers studied 1,350 kidney transplant recipients (between 2001 and 2009) at the University of Pittsburgh Starzl Transplant Institute, for posttransplant de novo and recurrent malignancy, excluding non-melanoma skin cancer, among patients receiving alemtuzumab, thymoglobulin and no induction therapies.
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Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: Incidence, risk factors and outcome
Transplant Infectious Disease
Neutropenic enterocolitis (NE) is a life-threatening complication occurring after intensive chemotherapy; however, no data are available on NE development after hematopoietic stem cell transplantation (SCT). The aim of a recent study was to determine the incidence, risk factors and outcome of NE after high-dose chemotherapy and autologous SCT (autoSCT).
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Early treatment of depressive symptoms and long-term survival after liver transplantation
American Journal of Transplantation (subscription required)
Adequate pharmacotherapy for depression within one year of liver transplantation was associated with improved survival rates in a recent study. Researchers evaluated 167 patients who underwent liver transplantation (LT) because of alcohol-related liver disease between 1998 and 2003. Symptoms of depression were assessed via the Beck Depression Inventory (BDI) every three months for the first year posttransplantation, and the adequacy of treatment with antidepressants among recipients was measured by the five-point Antidepressant Treatment History Form.
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