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Multidrug-resistant gram-negative bacteria infections in solid organ transplantation
American Journal of Transplantation (subscription required)
The prevalence of multidrug resistance in gram-negative bacteria isolated form clinical samples continues to increase globally. Several reports indicate a similar continued trend toward increased resistance in gram-negative bacteria isolated from transplant patients. Clinically important MDR bacteria that have been reported in transplant recipients include nonlactose fermenters such as Pseudomanas species, burkholderia species and stenotrophomas species, as well as carbapenem-resistant acinetobacter species and MDR anterobacteriaceae, with CR enterobacteriacaea being of particular concern. The impact of infection with MDR or PR bacteria on transplant recipient survival has become an important concern as several reports indicate significantly decreased survival of patients with such bacteria.
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PRESIDENT'S CORNER |
Roslyn Mannon, MD
Conversations with the President: Fighting for Biomedical Research
Political infighting, pundit bickering, fiscal slashing — Washington, DC can be a tough environment, especially when it comes to standing out in a crowd.
Our AST lobbyists, Bill Applegate and Chris Rorick of Bryan Cave, are in the trenches each day, directly lobbying the decision makers on Capitol Hill — most recently by educating and reminding them on a weekly basis about the significant benefits of a strong NIH and national biomedical research engine.
How do they do it? Read on...
Important ATC information
AST
Membership dues must be paid prior to April 1 to receive the member discounted registration rate to attend the 2013 ATC May 18-22 in Seattle. The member discounted rate will not be available if membership dues are submitted after April 1, and members who pay dues after April 1 will be required to register at the non-member rate. Additionally, members will not be able to pay membership dues on-site and then register on-site at the member discounted rate. Visit 2013.atcmeeting.org to register for the ATC. If you are uncertain whether your dues have been paid, or you have any other questions, please contact the AST office at info@myAST.org.
PRODUCT SHOWCASE
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Thompson Surgical Instruments, Inc. is the market leader in surgical retraction and the manufacturer of the original table mounted retractor. For more information, visit our website at thompsonsurgical.com or email us at info@thompsonsurgical.com.
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New Career Connections Event at ATC 2013
AST
The American Society of Transplantation and the Trainee and Young Faculty COP are pleased to announce our Career Connections event that will take place at the 2013 American Transplant Congress to aid your centers in hiring qualified individuals. Anyone who has an open position they are looking to fill, is attending ATC, and wants a convenient location to conduct interviews for their positions should contact the AST office at info@myAST.org for more information. This is a great opportunity to showcase your open positions to the most skilled professionals in transplantation! Additional information for job seekers will be made available in the coming weeks.
Last chance: Pay it Forward by Monday, April 1
AST
Pay it Forward and encourage your colleagues to join AST by the deadline of Monday, April 1st. Your recruitment efforts will help strengthen the transplantation community. When you Pay it Forward you'll be entered to win an iPad with retina display or AST bucks, and you'll be recognized at ATC, on the AST website and in the AST eNews. Learn more.
Webinar April 10 on Development of Solid Policies and Procedures — free to AST members
AST
"Development of Solid Policies and Procedures" is part of the Business of Transplantation webinar series and airs at 2 p.m. EST on Wednesday, Apr. 10. Register ahead of time at myAST.org/business; it's free for AST members and available for a small fee to non-members. Archives of webinars from November 2012-March 2013 are also available, as well as registration for the May and June webinars!
2013 Community of Practice Elections are now open!
AST
AST COP members are encouraged to vote in their community elections. To view the slate of candidates and cast your vote, click on the link below. You will be prompted to enter your username and password to access the voting site. We hope you will exercise your member privileges and vote.
http://www.myast.org/content/communities-practice-2013-elections
All votes must be received by Monday, April 22, 2013.
About Communities of Practice
AST's communities of practice are autonomous groups that develop around a common sense of purpose. Members participate in these groups as a way to share knowledge and network with colleagues. If you are not currently a member of a COP and would like to learn more, click here.
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Astellas Pharma US, Inc., a U.S. affiliate of Tokyo-based Astellas Pharma Inc., is a pharmaceutical company dedicated to changing tomorrow by improving the health of people around the world through innovative and reliable pharmaceutical products. For more information about Astellas Pharma US, Inc., please visit our Web site at www.astellas.us
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LIFECODES is introducing its new HLA-SSO kits. The new kit includes a validated, high-performance enzyme for improved reliability and performance with the continued ease of no centrifugation or wash steps; providing accurate, clear and easy to interpret results.
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Genzyme is committed to discovering and delivering transformative therapies for patients with rare and special unmet medical needs, providing hope where there was none before. MORE
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Hypothermic reconditioning in organ transplantation
Current Opinion in Organ Transplantation (subscription required)
Vascular and parenchymal tissue homeostasis can be restored to a notable extent in cold-preserved organ grafts by hypothermic reconditioning: A short period of preimplantation treatment allows for better graft function after transplantation in livers and kidneys. Hypothermic reconditioning represents a promising and easily applicable tool for post hoc enhancement of organ viability in marginal grafts and should be validated in randomized controlled trials.
Association between granzyme B and perforin I polymorphisms and allograft outcomes in Hispanic kidney transplant recipients
Clinical Transplantation
Granzyme B (GZMB) and perforin 1 gene (PRF1) are key effector molecules of cytotoxic T lymphocytes, in causing acute and chronic solid organ transplant rejection. In this study, researchers analyzed the impact of GZMB and PRF1 polymorphism on kidney allograft outcomes. The result suggests that PRF1 and GZMB gene polymorphisms may determine the incidence of acute rejection or graft survival among Hispanic allograft recipients.
Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients
Pediatric Transplantation (subscription required)
Outcomes of pediatric liver transplantation have constantly improved in the last decade. Living-related liver transplantation does not seem to improve long-term outcomes following liver transplantation, but few studies have evaluated immunological parameters of the alloimmune response after living vs. deceased donor organ transplantation. Researchers analyzed numbers of regulatory T cells, lymphocyte subsets and serum cytokine concentrations in 12 pediatric recipients of living-related liver transplants and in 28 pediatric recipients of deceased donor organs during their annual follow-ups. Living-related liver transplantation may have potentially beneficial immunological aspects, although long-term outcomes do not seem to be better in recipients of living donor organs than in recipients of deceased donor organs.
Review: Efficacy of carbon dioxide insufflation for cerebral and cardiac protection during open heart surgery
Artificial Organs (subscription required)
In spite of widespread application around the world, there has been controversy on the cerebral and cardiac protection efficacy of carbon dioxide insufflation (CDI) during open heart surgery. To make a comprehensive evaluation, researchers screened all relevant published randomized controlled trials to perform the first systematic review and meta-analysis for CDI during open heart surgery. Because of the insufficiency of powerful evidences, the cerebral and cardiac protection efficacy of CDI during open heart surgery needs to be further verified by more high-quality trials.
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Transplant IV Biologics and Oral Immunosuppressives specializing in Desensitization and AMR Treatment and Prevention. MORE
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact James DeBois at 469-420-2618.
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Missed last week's issue? See which articles your colleagues read most.
Vitamins A, D deficiencies common among patients evaluated for liver transplantation
Healio
Most liver transplant candidates are vitamin A- and vitamin D-deficient, with bilirubin levels, BMI and Child-Turcotte-Pugh class predictive of vitamin A deficiency, according to a recent study. Researchers performed a retrospective chart review of 63 patients who underwent liver transplantation at a single medical facility between January 2008 and September 2011. Demographic information was collected and levels of vitamins A, E and 25-OH-D were assessed, along with BMI, MELD score and Child-Turcotte-Pugh (CTP) class.
Time to death after withdrawal of treatment in donation after circulatory death (DCD) donors
Current Opinion in Organ Transplantation (subscription required)
Controlled donation after circulatory death (DCD) donors make an important contribution to organ transplantation but there is considerable scope for further increasing the conversion of potential to actual DCD organ donors. The period between withdrawal of life-supporting treatment and death (the withdrawal period) is a major determinant of whether organ donation proceeds and it is therefore timely to review recent relevant studies in this area.
The impact of C4d and microvascular inflammation
Clinical Transplantation (subscription required)
It is important to identify prognostically important morphologic criteria in posttransplant management to tailor therapy and improve outcomes. Therefore, using biopsies carried out for cause less than one year posttransplant, from an era when C4d staining and microvascular inflammation (MVI) were not clinically utilized, researchers studied the importance of C4d and MVI on graft survival. Snap-frozen first renal allograft biopsy specimens (done for cause) in the first post-transplant year from 1996 to 2001 were stained/examined for C4d, and pathology re-examined by a separate blinded pathologist. Graft outcomes in patients with and without MVI and/or C4d were compared.
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