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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   March 28, 2014


The role of donor-specific HLA alloantibodies in liver transplantation
American Journal of Transplantation (login required)
The impact of donor-specific HLA alloantibodies on short- and long-term liver transplant outcome is not clearly defined. While it is clear that not all levels of allosensitization produce overt clinical injury, and that liver allografts possess some degree of alloantibody resistance, alloantibody-mediated adverse consequences are increasingly being recognized.
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Upcoming free webinars and webinars on demand
The following webinars and journal club are scheduled for April, all are free to AST members and are available on demand after the live air date.
  • Journal Club on the role of Neuropilin-Semaphorin interactions in modulating Treg suppressor function; Wed., 4/9; register online
  • Fellows Webinar on Generic Immunosuppressants; Thurs., 4/10; register online
  • Discussion of Risk in Living Kidney Donors; Tues., 4/22; register online
AST also offers popular webinars on demand at and at, including understanding the new UNOS/OPTN kidney allocation policy.

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Monday is the final deadline to pay it forward
Just one week left to encourage your colleagues to join and experience the value, knowledge and community that AST membership has to offer. Pay it Forward and grow personally and professionally by helping to strengthen the transplant community!

For each new member that you recruit, your name will be entered to win one of three prizes, including an iPad and AST Bucks! You will receive recognition for your efforts at the 2014 World Transplant Congress (WTC), on the AST website, and in the AST eNews. Encourage your colleagues to complete a membership application by Monday, March 31, so that they may register for the WTC at the member discounted registration rate. Click here for more details.

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Stephen Harms named UNOS Chief Operating Officer
United Network for Organ Sharing
Stephen Harms has been selected as chief operating officer of UNOS (United Network for Organ Sharing). UNOS matches donated organs with transplant candidates nationwide and manages the national transplant database through contract with the U.S. Department of Health and Human Services.
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National assessment of early biliary complications following liver transplantation: Incidence and outcomes
Liver Transplantation (login required)
Despite improved overall liver transplant outcomes, biliary complications remain a significant cause of morbidity. A national data set linking transplant registry and Medicare claims data for 17,012 liver transplant recipients was used to identify all recipients with a posttransplant biliary diagnosis code within the first six months after transplantation. Patients were further categorized as follows: a diagnosis without a procedure, a diagnosis and an associated radiological or endoscopic procedure, or a diagnosis treated with surgery.
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Academic potential and cognitive functioning of long-term survivors after childhood liver transplantation
Pediatric Transplantation (login required)
This cross-sectional study assessed intellect, cognition, academic function, behavior and emotional health of long-term survivors after childhood liver transplantation. Eligible children were more than five years post-transplant, still attending school and resident in Queensland. Hearing and neurocognitive testing were performed on 13 transplanted children and six siblings including two twin pairs where one was transplanted and the other not.
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Medical outcomes of adolescent live kidney donors
Pediatric Transplantation (login required)
Living kidney donation from donors less than 18 years of age is uncommon. The majority of donations from adolescents took place several decades ago providing a unique opportunity to study true long-term consequences of donation. In this study, authors compared survival, renal outcomes and rates of hypertension and diabetes among 42 adolescent donors and matched older controls
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Missed last week's issue? See which articles your colleagues read most.

    AST, transplant patient stakeholders claim victory, community applauds decision by CMS to abandon Medicare immunosuppressive drug coverage changes (The Hill)
UNOS announces 2014-2015 Board of Directors election results (AST)
The role of procurement biopsies in acceptance decisions for kidneys received for transplant (CJASN)
Study: Pneumonia in solid organ transplant recipients (Transplant Infectious Disease)

Don't be left behind. Click here to see what else you missed.

Transplantation genetics: current status and prospects
American Journal of Transplantation
Over the last decade, advances in genetic technologies have accelerated our understanding of the genetic diversity across individuals and populations. Case–control and population-based studies have led to several thousand genetic associations across a range of phenotypes and traits being unveiled. Despite widespread and successful use of organ transplantation as a curative therapy for organ failure, genetic research has yet to make a major impact on transplantation practice aside from HLA matching. New studies indicate that non-HLA loci, termed minor histocompatibility antigens (mHAs), may play an important role in graft rejection.
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