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AST Board of Directors Elections – now open
Voting is now open for the 2015-2016 Board of Directors! All eligible AST members are encouraged to vote. The deadline to vote is 5 p.m. EST on Monday, May 4, 2015. The election results will be announced at the AST Town Hall Meeting during the American Transplant Congress.: Monday, May 4, 2015, at 5:45 p.m. EST.
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Still time left to vote in the 2015 Community of Practice (COP) Elections
AST COP Members: Be sure to vote for members of your COP Executive Committee if you have not already voted. Simply click here and select one or more of your communities of practice. You will be prompted to enter your username and password if you are not logged in to the AST website. Voting closes on Friday, April 10.
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QAPI Webinar: Objective Measures – Monitoring & Evaluating Services
Join us and ASTS on Wednesday, April 8 at Noon ET for the third installment of a monthly webinar series designed and presented by the Centers for Medicare and Medicaid Services. This webinar will offer an insightful look into developing objective measures that allow monitoring and evaluation of transplantation activities in order to improve outcomes. Register today!

The content of this presentation is determined independently by CMS without input or endorsement from either the ASTS or AST. Both societies appreciate CMS providing this information to the transplant community and are pleased to facilitate that process.

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You care about your transplant patients. And so do we. That’s why we’re introducing Astellas Cares—a new program that offers you customized tools, educational resources, and comprehensive support to help your patients care for their health. To register, visit today.


Mark your calendar! AST Town Hall and Excellence in Transplantation Reception at ATC
We invite all AST members to attend the AST Town Hall meeting at ATC on Monday, May 4, at 5:45 p.m. This meeting provides a forum for open discussion between AST membership and leadership about key issues impacting our society and field of transplantation.

Immediately following the Town Hall meeting, join friends and colleagues for the Excellence in Transplantation Reception. 

Let us know if you're coming! RSVP here.

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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE


AST/ASTS Workshop on increasing organ donation in the United States: Creating an 'arc of change' from removing disincentives to testing incentives
American Journal of Transplantation
The American Society of Transplantation (AST) and American Society of Transplant Surgeons (ASTS) convened a workshop on June 2–3, 2014, to explore increasing both living and deceased organ donation in the United States. Recent articles in the lay press on illegal organ sales and transplant tourism highlight the impact of the current black market in kidneys that accompanies the growing global organ shortage. We believe it important not to conflate the illegal market for organs, which we reject in the strongest possible terms, with the potential in the United States for concerted action to remove all remaining financial disincentives for donors and critically consider testing the impact and acceptability of incentives to increase organ availability in the United States.

Related article: Innovative strategies needed to address the US transplant organ shortage

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Livebirth after uterus transplantation
The Lancet
Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet been reported.
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Safety and efficacy of splenic artery embolization for portal hyperperfusion in liver transplant recipients: A 5-year experience
Liver Transplantation
Severe portal hyperperfusion (PHP) after liver transplantation has been shown to cause intrahepatic arterial vasoconstriction secondary to increased adenosine washout (hepatic artery buffer response). Clinically, posttransplant PHP can cause severe cases of refractory ascites and hydrothorax. In the past, we reported our preliminary experience with the use of splenic artery embolization (SAE) as a way to reduce PHP. Here we present our 5-year experience with SAE in orthotopic liver transplantation (OLT).
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Immunization after renal transplantation: Current clinical practice
Transplant Infectious Disease
The use of potent immunosuppressive drugs and increased travel by renal transplant recipients (RTR) has augmented the risk for infectious complications. Immunizations and changes in lifestyle are protective. The Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group has developed guidelines on vaccination following solid organ transplantation. The degree of adherence to these guidelines is unknown, as is which barriers must be overcome to improve adherence.
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Induction therapy: Clinical and quality of life outcomes in aged renal transplant recipients
Clinical Transplantation
One primary purpose of transplant is to improve quality of life (QOL) in renal transplant recipients (RTRs) less than or equal to 50 years of age, where death with a functioning graft limits life years gained. This study aimed to determine the impact of induction therapy, with its subsequent effects on rejection, infection, and readmissions, on QOL.
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Salt accelerates allograft rejection through serum- and glucocorticoid-regulated kinase-1– dependent inhibition of regulatory T cells
Journal of the American Nephrology Society
A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using a murine transplantation model, we investigated the effect of NaCl on the alloimmune response in vitro and in vivo. Incremental NaCl concentrations in vitro augmented T cell proliferation in the settings of both polyclonal and allospecific stimulation.
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Missed last week's issue? See which articles your colleagues read most.

    Saving lives through transplantation: A truly bipartisan issue (AST)
AST comments on OPTN/UNOS policy proposals (AST)
Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States (Gastroenterology)
Commercially available immunoglobulins contain virus neutralizing antibodies against all major genotypes of polyomavirus BK (American Journal of Transplantation)

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Colby Horton, Vice President of Publishing, 469.420.2601
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Julie Bernhard, Executive Editor, 469.420.2647  
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