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Practical guidance on the evaluation of potential organ donors for meningoencephalitis
The Organ Procurement and Transplantation Network
The recent transmission of rabies from an infected donor to an organ recipient is a reminder that potential organ donors need to be carefully evaluated for the presence of meningoencephalitis. The Organ Procurement and Transplantation Network, together with the United Network for Organ Sharing, has developed this document detailing the Ad Hoc Disease Transmission Advisory Committee's (DTAC) practical guidance on the evaluation of potential organ donors for meningoencephalitis during the screening procedure. 
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SOCIETY NEWS


AST Institutional Support Program
  • Are you interested in receiving recognition and increased exposure for your transplant center?
  • Does your center support the future of transplantation and value the educational, networking and research opportunities that the American Society of Transplantation (AST) provides to its members?
  • Does your center support AST's lobbying of the U.S. Congress and Federal Agencies to secure a more transplant provider friendly environment for patients and physicians?

    If the answer to these questions is YES, please consider having your center participate in AST's Institutional Support Program. With a charitable contribution of $3,000, your center will receive valuable benefits. For more information and to make a contribution, click here. All donations are tax-deductible.

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    Slides with audio from AST's Cutting Edge of Transplantation
    If you missed AST's first annual Cutting Edge of Transplantation this past February, you can view the session recordings online when it's convenient for you. Access is free for AST members, and non-members can purchase access for just $99. Instructions for viewing more than 15 hours of cutting edge content can be found here.
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    Webinar April 10 on Development of Solid Policies and Procedures — free to AST members
    "Development of Solid Policies and Procedures" is part of the Business of Transplantation webinar series and airs at 2 p.m. EST on Wednesday, April 10. Click here to register in advance; it's free for AST members and available for a small fee to non-members. Archives of webinars from November 2012-March 2013 are also available, as well as registration for the May and June webinars.
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    COP CORNER


    2013 Community of Practice elections are now open!
    AST COP members are encouraged to vote in their community elections. To view the slate of candidates and cast your vote, click here. You will be prompted to enter your username and password to access the voting site. We hope you will exercise your member privileges and vote. All votes must be received by Monday, April 22.

    About the COPs: COPs are autonomous groups within the AST that participate in projects important to a specific specialty area. For a complete list of all COPs or to join a COP, visit our website.

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    TRANSPLANT NEWS


    Carbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patients
    Cleveland Clinic Journal of Medicine
    The emergence of carbapenem-resistant Enterobacteriaceae (CRE) highlights the importance of effective antibiotics to maintain the safety of our healthcare system. Clinicians will encounter CRE as a cause of difficult-to-treat and often fatal infections in hospitalized patients. This review examines the mechanisms of carbapenem resistance, the dissemination and clinical impact of these resistant organisms and challenges to their detection, treatment and control.
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    TRENDING ARTICLES
    Missed last week's issue? See which articles your colleagues read most.

        Microvascular damage in type 1 diabetic patients is reversed in the first year after simultaneous pancreas–kidney transplantation (American Journal of Transplantation)
    'Warmed liver' transplant first (BBC News)
    CDC confirms rabies death in organ transplant recipient (Centers for Disease Control and Prevention)
    Coronary events in patients undergoing orthotopic liver transplantation: Perioperative evaluation and management (Clinical Transplantation)
    Old age alone should not prevent kidney transplants (Renal & Urology News)
    Don't be left behind. Click here to see what else you missed.


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    HCV coinfection not predictive of kidney disease in liver transplant recipients with HIV
    Healio
    Liver transplant recipients with HIV and hepatitis C were not at increased risk for chronic kidney disease compared with those with HIV alone, but coinfection may be linked to more advanced disease, according to recent results. Researchers evaluated data from 81 patients coinfected with HCV and HIV and 35 with HIV who underwent orthotopic liver transplantation between 2003 and 2010. Chronic kidney disease (CKD) prevalence before transplantation and one and three years after was determined in each group, with a median follow-up of 3.6 years.
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    Organogenesis for kidney regeneration
    Current Opinion in Organ Transplantation (subscription required)
    The kidney has an elaborate and complicated structure comprising several cell types. Damage or destruction of the kidney thus necessitates reconstruction of all the component cell types to regenerate a functional three-dimensional renal structure. Therefore, despite all the recent advances in the understanding of and technical approaches to stem cell and developmental biology, the anatomical complexity of the renal system makes de novo kidney regeneration the most difficult challenge for organ regenerative therapy.
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    Local access to subspecialty care influences the chance of receiving a liver transplant
    Liver Transplantation (subscription required)
    Prior studies have examined the impact of demographic factors on liver transplant outcomes. These factors may be surrogate markers for access to medical care. A recent study investigated physician density in referred patients' hospital service areas (HSAs) as a factor in patients' probability of receiving a liver transplant. Researchers recently performed a retrospective review of patients referred for liver transplantation from 2002-2010.
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    Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model
    Xenotransplantation (subscription required)
    Researchers investigated whether graft produced anti-human CD2, mediated by adenovirus (Adv) transduction of pig neonatal islet cell clusters (pNICC), would protect xenografts in a humanized mouse model from immune attack and whether such immunosuppression would remain local. A mouse anti-human CD2 Ab (CD2hb11) previously generated by us was genetically engineered to produce chimeric and humanized versions.
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    Pretransplant cancers might be overlooked
    Renal & Urology News
    Many cancers found after kidney transplantation might have been present prior to surgery and possibly could have been detected during the pretransplant workup, according to results from a new study. In a group of 3,524 kidney transplant recipients in Quebec, 36 neoplasias were detected within a year of surgery. Of these, 16 (44 percent) may have been present before transplantation and could have been detected during the routine pretransplant workup.
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    Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
    Liver Transplantation (subscription required)
    Recurrent hepatitis C virus (HCV) infection is associated with accelerated fibrosis rates after liver transplantation (LT) and is the leading cause of graft failure. Furthermore, distinguishing recurrent HCV from acute cellular rejection (ACR) can be problematic, and this can lead to inappropriate treatments and adverse outcomes. It has been hypothesized that intragraft microRNA (miRNA) expression profiles could distinguish the severity of recurrent HCV and differentiate recurrent HCV from ACR. Researchers have established meticulously matched post-LT patient cohorts in order to derive robust global miRNA expression profiles and minimize the impact of variables known to influence HCV recurrence.
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