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AST Board of Directors Elections – now open
Voting is now open for the 2015-2016 Board of Directors! All eligible AST members are encouraged to vote. The deadline to vote is 5 p.m. EST on Monday, May 4, 2015. The election results will be announced at the AST Town Hall Meeting during the American Transplant Congress: Monday, May 4, 2015, at 5:45 p.m. EST.
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Take part in AST's Pay it Forward Campaign and enter to win an Apple gift card or AST Bucks!
Time is running out for you to talk to your colleagues about the benefits of AST membership that you find most valuable. Encourage your colleagues to join today and you’ll both strengthen the transplant community and help each other grow personally and professionally.

For each new member that you recruit, your name will be entered to win one of three prizes. Additionally, you’ll receive recognition for your efforts at the 2015 American Transplant Congress (ATC), on the AST website, and in the AST eNews. Encourage your colleagues to complete a membership application by April 15, 2015 so that they can register for the ATC at the member discounted registration rate. For further details please visit:

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You care about your transplant patients. And so do we. That’s why we’re introducing Astellas Cares—a new program that offers you customized tools, educational resources, and comprehensive support to help your patients care for their health. To register, visit today.

Community of Practice (COP) Elections – CLOSING TODAY
AST COP Members: Be sure to vote for members of your COP Executive Committee if you have not already voted. Simply click here and select one or more of your communities of practice. You will be prompted to enter your username and password if you are not logged in to the AST website. Voting closes today (Friday, April 10).
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WEBINAR: Cytomegalovirus: Prevention, Therapy, Immunity
Register today at for this CMV webinar taking place on Tuesday, April 21 from 2-3 pm ET. This webinar is free for AST members and groups are welcome to view together.

After participating in this webinar, you will be able to:
  • Discuss the importance of CMV prevention, along with the various approaches used for optimal prevention
  • Explain the standard treatment for CMV infection and disease in transplant recipients and discuss novel antiviral drugs
  • Describe the potential for using immune monitoring tools to refine and improve prevention and treatment strategies

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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE


Mark your calendar! AST Town Hall and Excellence in Transplantation Reception at ATC
We invite all AST members to attend the AST Town Hall meeting at ATC on Monday, May 4, at 5:45 p.m. This meeting provides a forum for open discussion between AST membership and leadership about key issues impacting our society and field of transplantation. Immediately following the Town Hall meeting, join friends and colleagues for the Excellence in Transplantation Reception.

Let us know if you're coming! RSVP here.

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HIV-positive–to–HIV-positive kidney transplantation — results at 3 to 5 years
The New England Journal of Medicine
The outcome of kidney transplantation in human immunodeficiency virus (HIV)–positive patients who receive organs from HIV-negative donors has been reported to be similar to the outcome in HIV-negative recipients. We report the outcomes at 3 to 5 years in HIV-positive patients who received kidneys from HIV-positive deceased donors.
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Pediatric intestinal transplant listing criteria – a call for a change in the new era of intestinal failure outcomes
American Journal of Transplantation
Current listing indications used for intestinal transplantation (IT) were proposed in 2001. We undertook the present single center study to see if these criteria are still valid. The 2001 criteria (advanced cholestasis, loss of greater than 50 percent central venous catheter (CVC) sites, greater than or equal to 2 sepsis/year, ultrashort bowel) were compared in children with intestinal failure in old era—1998–2005 (N = 99) to current era—2006–2012 (N = 91) to predict the need for IT using sensitivity, specificity, NPV and PPV.
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.

UNOS regional variations in appeal denial rates with non-standard MELD/PELD exceptions: Support for a National Review Board
Clinical Transplantation
Although it has been generally recognized that there are inconsistencies among Regional Review Boards in the assignment of points for MELD/PELD exception patients with resulting considerable variation in appeal denial rates, data to actually prove this has been limited. We reviewed 6,533 MELD/PELD exception applications submitted between 2005 and 2008, calculated the variation in approval/denial rates, and followed these cases through mid-2013 to assess the effects on patient outcomes.
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Gut microbiota and tacrolimus dosing in kidney transplantation
Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a challenging task because of much interpatient and intrapatient variability in drug absorption, metabolism, and disposition. In view of the reported impact of gut microbial species on drug metabolism, we investigated the relationship between the gut microbiota and tacrolimus dosing requirements in this pilot study of adult kidney transplant recipients.
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Pregnancy outcomes for kidney transplant recipients with transplantation as a child
JAMA Pediatrics
The aim of this study was to report pregnancy outcomes for women with kidney transplantation in childhood (aged less than 18 years; child-tx mothers) and to compare them with those for women who received a kidney transplant in adulthood (aged greater than or equal to 18 years; adult-tx mothers).
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Missed last week's issue? See which articles your colleagues read most.

    Immunization after renal transplantation: Current clinical practice (Transplant Infectious Disease)
AST/ASTS Workshop on increasing organ donation in the United States: Creating an 'arc of change' from removing disincentives to testing incentives (AST)
Induction therapy: Clinical and quality of life outcomes in aged renal transplant recipients (Clinical Transplantation)
Still time left to vote in the 2015 Community of Practice (COP) Elections (AST)
AST Board of Directors Elections – now open (AST)

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Colby Horton, Vice President of Publishing, 469.420.2601
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Julie Bernhard, Executive Editor, 469.420.2647  
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