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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Apr. 19, 2013


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Transmission of Strongyloides stercoralis through transplantation of solid organs
Centers for Disease Control and Prevention
Strongyloides stercoralis is an intestinal nematode endemic in the tropics and subtropics. Immunocompetent hosts typically are asymptomatic, despite chronic Strongyloides infection. In contrast, immunocompromised patients are at risk for hyperinfection syndrome and disseminated disease, with a fatality rate more than 50 percent (1–3). The infection source for immunocompromised patients, such as solid organ transplant recipients, is not always apparent and might result from reactivation of chronic infection after initiation of immunosuppressive therapy or transmission from the donor.
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SOCIETY NEWS


New educational activity: CMV pathway case management
AST has endorsed a new free, interactive online activity, Pathways in CMV Case Management. This CME/CE activity was developed by Spire Learning and is supported by an educational grant from Genentech. Learn how to evaluate your transplant center's protocols for preventing and managing CMV disease in transplant recipients, and how to select the appropriate strategies to prevent and manage CMV disease in adult and pediatric transplant recipients. Take part in this activity today.
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2013 Banff Conference on Allograft Pathology
AST is pleased to endorse the 2013 Banff Conference on Allograft Pathology in Comandatuba-Bahia, Brazil, Aug. 19-23. The conference also features a pre-meeting symposium Aug. 17-18 on transplant immunobiology and immunopathology. Register now for this exciting event. Stay up-to-date with the Banff Conference on Facebook!
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AST town hall meeting: Many voices, one goal
AST members are invited to attend a town hall meeting at ATC on Monday, May 20 at 5:45 p.m. in room 2 A/B at the Washington State Convention Center. The town hall will provide a forum for open discussion between the membership and the leadership about key issues impacting the society and field of transplantation, and how the society is positioned to address those key issues. In addition, we'll announce the Board of Director election results, recognize and honor AST volunteer leadership, and award the 2013 research grants. RSVP for the Town Hall/Excellence in Transplantation Reception here.

If you are not already an AST member and are interested in learning more, click here to complete an online membership application. The town hall meeting is supported in part with funding from Genentech, Sanofi and Association Headquarters.

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Attention job seekers: Participate in AST's Career Connections at ATC
Are you currently looking for a new position in the field of transplantation? Will you be attending the ATC in Seattle? Then we encourage you to browse AST's Career Center for open jobs and participate in the ATC Career Connections Event! All job postings with the ATC logo next to them indicate that the employer will also be attending ATC, and is looking to potentially interview candidates while both parties are at the meeting. Should an employer wish to meet with you, they will coordinate a mutually convenient time, and AST will provide a space for the interview to be conducted. Learn more about this opportunity here. If you have any questions, please contact the AST National Office at info@myAST.org.
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Slides with audio from AST's Cutting Edge of Transplantation
If you missed AST's first annual Cutting Edge of Transplantation this past February, you can view the session recordings online when it's convenient for you. Access is free for AST members, and non-members can purchase access for just $99. Instructions for viewing more than 15 hours of cutting edge content can be found here.
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AST board of directors online elections now open
Eligible AST members are encouraged to cast their votes for the AST board of directors, as well as various bylaw revisions. The voting site will prompt you to login to the AST website where you will find more detailed information. Usernames and passwords were sent to eligible members earlier this week.

Election results will be announced at the AST Town Hall meeting at ATC on Monday, May 20, at 5:45 p.m. in Room 2 A/B of the Washington State Convention Center. Email Nicole Poponi, AST director of membership, with questions.

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COP CORNER


Cast your vote in the 2013 Community of Practice elections!
AST COP members are encouraged to vote in their community elections. To view the slate of candidates and cast your vote, click here. You will be prompted to enter your username and password to access the voting site. We hope you will exercise your member privileges and vote. All votes must be received by Monday, April 22.

About the COPs: COPs are autonomous groups within the AST that participate in projects important to a specific specialty area. For a complete list of all COPs or to join a COP, visit our website.

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TRANSPLANT NEWS


Innate immunity in donor procurement
Current Opinion in Organ Transplantation
Ischemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischemia. This review discusses the components of innate immunity known to be involved in renal ischemic reperfusion injury (IRI). Understanding how inflammatory damage is initiated in renal IRI is important for the development of targeted therapies aimed at preserving the donor organ.
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Reciprocal interaction between intestinal microbiota and mucosal lymphocyte in cynomolgus monkeys after alemtuzumab treatment
American Journal of Transplantation (login reqiured)
It has been known that the gut microbiota plays a central role in shaping normal mucosal immunity, however, little information is available whether the variability of mucosal lymphocytes impacts the commensal flora. Here, researchers applied a cynomolgus monkey model to characterize the structure and composition of the gut microbiota in response to lymphocyte depletion and to determine their potential association.
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Relationship between occurrence of surgical complications and hospital finances
JAMA
In this hospital system, the occurrence of postsurgical complications was associated with a higher per-encounter hospital contribution margin for patients covered by Medicare and private insurance but a lower one for patients covered by Medicaid and who self-paid. Depending on payer mix, many hospitals have the potential for adverse near-term financial consequences for decreasing postsurgical complications.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury (American Journal of Transplantation)
Prostate cancer need not preclude kidney transplants (Renal & Urology News)
Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: Initial clinical experience (The Journal of Heart and Lung Transplantation)

Don't be left behind. Click here to see what else you missed.


Outcomes and predictive factors of pediatric kidney transplants: An analysis of the Thai Transplant Registry
Pediatric Transplantation (login required)
As universal coverage for pediatric kidney transplantation (KT) was introduced in Thailand in 2008, the number of recipients has been increasing. Researchers evaluated predictive factors for graft failure to understand how to improve clinical outcomes in these children. Using data obtained from the National Transplant registry, they assessed the risk of graft failure using the Kaplan–Meier method and Cox proportional hazards regression.
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Rat kidneys made in lab point to aid for humans
The New York Times
Researchers at Massachusetts General Hospital in Boston have made functioning rat kidneys in the laboratory, a bioengineering achievement that may one day lead to the ability to create replacement organs for people with kidney disease. The scientists said the rat kidneys produced urine in the laboratory as well as when transplanted into rats. The kidneys were made by stripping donor kidneys of their cells and putting new cells that regenerate tissue into them.
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The need to reduce cold ischemia time in kidney transplantation
Current Opinion in Organ Transplantation (subscription required)
Hypothermic preservation is a prerequisite for kidney exchange in transplantation. The severity of tissue damage caused by hypothermic preservation influences the level of ischemia/reperfusion injury and subsequent graft function. With the purpose of reviewing the implications of prolonged cold ischemia time (CIT) in kidney transplantation, its pathophysiology, effects on early and late outcome of transplantation for different types of deceased organ donors, and preservation methods are discussed based on recent literature.
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Vascularized composite tissue allotransplantation — state of the art
Clinical Transplantation (login required)
Vascularized composite tissue allotransplantation is a viable treatment option for injuries and defects that involve multiple layers of functional tissue. In the past 15 years, more than 150 vascularized composite allotransplantation (VCA) surgeries have been reported for various anatomic locations including — but not limited to — trachea, larynx, abdominal wall, face and upper and lower extremities. VCA can achieve a level of esthetic and functional restoration that is currently unattainable using conventional reconstructive techniques.
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Suppression of NF-kappaB p65 expression attenuates delayed xenograft rejection
Xenotransplantation
Delayed xenograft rejection (DXR) involves type II vascular endothelial cell (VEC) activation including upregulation of pro-inflammatory genes, which contributes to infiltration into the graft and a complex process of cytokine production. Approaches to prevent DXR have shown limited success. In this study, researchers modified heart donors using siRNA in an attempt to attenuate DXR and to improve xenograft survival in the mouse-to-rat heterotopic heart transplant model.
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Duodenal Infusion of donor feces for recurrent Clostridium difficile
The New England Journal of Medicine (login required)
Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. Researchers studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection.
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