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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   May 02, 2014


OPTN Safety Alert: Baxter recall of sodium chloride irrigation
Transplant Pro
UNOS was alerted through our Patient Safety Portal that Baxter International, Inc., has issued a voluntary recall for one lot of 0.9 percent sodium chloride irrigation solution in a 1000 mL plastic bottle. The recall is dated April 21. The containers in this specific lot may contain particulate matter that might contribute to potential wound irritation, local infection or sepsis.
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AST + ESOT Joint Meeting: Personalized Transplantation: From New Diagnostics to New Therapeutics
Oct. 17-19
Madrid, Spain

Come to Spain this fall as we explore:
  • New Options to Improve Immunosuppressive Therapy: Belatacept, Anti CD40 trial (ASKP1240), Anti- IL-6 and Tacrolimus formulations
  • Novel Diagnostics: Donor DNA - Biomarker of Graft Injury, In vivo Live Imaging of the Immune Response and Tolerance Profile
  • Novel Targets for Immunosuppression: B-cells, Plasma Cells and Complement
  • Personalized Medicine: Technique and Technology: Sequencing for TCR Repertoire, Pharmacogenetics, Epigenetics and Mixed Chimerism
  • Cellular Strategies to Optimize Long Term Outcomes: T-regs, Mesenchymal Cells, Facilitator Cells
Be a part of the program! Submit your clinical, translational and basic abstracts on Novel Immune Monitoring and/or Diagnostics and Immunosuppression Strategies. Abstract Submission Deadline: Sunday, June 29.

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Upcoming Free Webinars and Webinars on Demand
The following webinars and journal club are scheduled for May; all are free to AST members and are available on demand after the live air date.
  • Fellows Webinar on Donor Acceptance, Wed., May 7; register online
  • Business of Transplantation Webinar on CUSUM and Bayesian Charts (new SRTR reporting methodologies); register online
  • Webinar on Role of HLA Testing in Pre- and Post-transplant Monitoring for SOT, Tues., April 22; register online
  • Journal Club on Risk of End-Stage Renal Disease Following Live Kidney Donation, Thurs., May 29; register online
AST also offers popular webinars and journal clubs on demand at,, and

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First-in-human study of the safety and efficacy of TOL101 induction to prevent kidney transplant rejection
American Journal of Transplantation
TOL101 is a murine IgM mAb targeting the αβ TCR. Unlike other T cell targets, the αβ TCR has no known intracellular signaling domains and may provide a nonmitogenic target for T cell inactivation. Authors report the 6-month Phase 2 trial data testing TOL101 in kidney transplantation. The study was designed to identify a dose that resulted in significant CD3 T cell modulation (<25 T cell/mm3), to examine the safety and tolerability of TOL101 and to obtain preliminary efficacy information.
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Procurement for visceral organ transplantation: where to cannulate and how to perfuse?
Current Opinion in Organ Transplantation (login required)
Despite significant improvements in visceral organ transplantation over the last few decades, some technical aspects of organ harvesting remain controversial. The purpose of this article is to review and summarize the latest literature on how to perfuse in multiorgan procurement.
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Acute rejection linked to ketoconazole
Renal & Urology News
Using ketoconazole in combination with tacrolimus in kidney transplant patients may increase their risk of acute rejection, according to findings presented at the National Kidney Foundation's 2014 Spring Clinical Meetings in Las Vegas.
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Vitamin D deficiency, parathyroid hormone levels and bone disease among patients with end-stage liver disease and normal serum creatinine
Clinical Transplantation (login required)
Vitamin D deficiency is common among patients with end-stage liver disease. The primary aim of this study was to assess the prevalence of vitamin D deficiency, secondary hyperparathyroidism and bone disease in patients with ESLD awaiting LT.
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UCLA Immunogenetics Center

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The University Of Utah Department Of Surgery is seeking applications for a faculty member to join the multi-organ transplant team at the assistant professor level. This is an opportunity to join an expanding program and a cohesive group of transplant surgeons focused on excellence. The candidate should be board certified in general surgery and have completed an ASTS approved transplantation surgery fellowship. Apply here
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Impact of urinary tract infection on allograft function after kidney transplantation
Clinical Transplantation (login required)
Urinary tract infection is the most common infectious complication after kidney transplantation. We aim to determine its impact on allograft function as indicated by several measures such as iothalamate glomerular filtration rate, estimated glomerular filtration rate, and creatinine value.
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Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome gene expression profiling
American Journal of Transplantation (login required)
There are no minimally invasive diagnostic metrics for acute kidney transplant rejection, especially in the setting of the common confounding diagnosis, acute dysfunction with no rejection. Thus, though kidney transplant biopsies remain the gold standard, they are invasive, have substantial risks, sampling error issues and significant costs and are not suitable for serial monitoring. Global gene expression profiles of 148 peripheral blood samples from transplant patients with excellent function and normal histology, AR and ADNR, from two independent cohorts were analyzed with DNA microarrays.
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Missed last week's issue? See which articles your colleagues read most.

    Scientific retreat of international transplants skin cancer collaborative and skin cancer in organ transplant patients in Europe (American Journal of Transplantation (login required))
Review: Desensitization in kidney transplantation (Clinical Transplantation (login required))
UNOS resources on KPD and new kidney allocation system (TransplantPro)
Early hospital readmissions post-kidney transplantation are associated with inferior clinical outcomes (Clinical Transplantation (login required))

Don't be left behind. Click here to see what else you missed.

Ascites and serum sodium are markers of increased waiting list mortality in children with chronic liver failure
Ascites is the most common complication of cirrhosis and in adults it is associated with 50% mortality at 5 years if patients do not receive a liver transplant. The occurrence of hyponatremia in these patients has been associated with increased mortality on the waiting list. The importance of serum sodium levels and the presence of ascites in the pediatric setting remain to be clarified.
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Diarrhea caused by viruses in transplant recipients
Transplant Infectious Disease
Diarrhea is a common complication after solid organ transplantation, and viruses are emerging as important but underestimated causative agents. Viral infections in solid organ transplant recipients can result in severe and prolonged diarrhea with significant patient morbidity and graft complications. Cytomegalovirus remains the most common of the viruses to cause diarrhea, but other viruses are being increasingly recognized, including norovirus, rotavirus and adenovirus. This article reviews the epidemiology, clinical presentation, diagnosis, management and outcomes of these viral causes of diarrhea in SOT patients.
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Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation
American Journal of Transplantation (login required)
To reduce widespread shortages, attempts are made to use more marginal livers for transplantation. Many of these grafts are discarded for fear of inferior survival rates or biliary complications. Recent advances in organ preservation have shown that ex vivo subnormothermic machine perfusion has the potential to improve preservation and recover marginal livers pretransplantation.
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