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Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   May 23, 2014


The microbiota, the immune system and the allograft
American Journal of Transplantation (login required)
The microbiota represents the complex collections of microbial communities that colonize a host. In health, the microbiota is essential for metabolism, protection against pathogens and maturation of the immune system. In return, the immune system determines the composition of the microbiota. Altered microbial composition (dysbiosis) has been correlated with a number of diseases in humans. The tight reciprocal immune/microbial interactions complicate determining whether dysbiosis is a cause and/or a consequence of immune dysregulation and disease initiation or progression. However, a number of studies in germ-free and antibiotic-treated animal models support causal roles for intestinal bacteria in disease susceptibility.
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Now accepting abstracts
AST + ESOT Joint Meeting
Personalized Transplantation: From New Diagnostics to New Therapeutics

Oct. 17-19
Madrid, Spain

Come to Spain this fall as we explore:
  • New Options to Improve Immunosuppressive Therapy Belatacept, Anti CD40 trial (ASKP1240), Anti- IL-6 and Tacrolimus formulations
  • Novel Diagnostics Donor DNA - Biomarker of Graft Injury, In vivo Live Imaging of the Immune Response and Tolerance Profile
  • Novel Targets for Immunosuppression B-cells, Plasma Cells and Complement
  • Personalized Medicine: Technique and Technology Sequencing for TCR Repertoire, Pharmacogenetics, Epigenetics and Mixed Chimerism
  • Cellular Strategies to Optimize Long Term Outcomes T-regs, Mesenchymal Cells, Facilitator Cells
Be a part of the program! Submit your clinical, translational and basic abstracts on Novel Immune Monitoring and/or Diagnostics and Immunosuppression Strategies. Submission Deadline: Sunday, June 29

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Upcoming free webinars and webinars on demand
The following webinars and journal club are scheduled for May; all are free to AST members and are available on demand after the live air date. 
  • Journal Club on Risk of End-Stage Renal Disease Following Live Kidney Donation,Thurs., May 29; register online
  • Fellows Webinar on Malignancies after SOT, Wed., June 4; register online
  • Business of Transplantation Webinar on OPO Quality Programs, Wed., June 11; register online
  • Journal Club on "A committed precursor to innate lymphoid cells", Tues., June 24, register online
AST also offers popular webinars and journal clubs on demand at,, and

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Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria
Transplantation (login required)
The strategy of evaluating every donation opportunity warrants an investigation into the financial feasibility of this practice. The purpose of this investigation is to measure resource utilization required for procurement of transplantable organs in an organ procurement organization (OPO).
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The extent and predictors of waiting time geographic disparity in kidney transplantation in the United States
Transplantation (login required)
Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation.
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Liver transplantation in recipients receiving renal replacement therapy: Outcomes analysis and the role of intraoperative hemodialysis
American Journal of Transplantation (login required)
The Model for End-Stage Liver Disease system has dramatically increased the number of recipients requiring pretransplant renal replacement therapy prior to liver transplantation. Factors affecting post-LT outcomes and the need for intraoperative RRT were analyzed in 500 consecutive recipients receiving pretransplant RRT, including comparisons among recipients not receiving IORRT, receiving planned IORRT, and receiving emergent, unplanned RRT after LT initiation.
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Lung transplantation following hematopoietic stem cell transplantation: report of two cases and systematic review of literature
Clinical Transplantation (login required)
Non-infectious pulmonary complications following hematopoietic stem cell transplantation are major cause of morbidity and mortality with limited treatment options. Lung transplantation has been rarely reported as a treatment option for selected HSCT recipients with these problems.
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Medication adherence in the transition of adolescent kidney transplant recipients to the adult care
Pediatric Transplantation (login required)
Non-adherence is common in adolescent and young adult kidney transplant recipients, leading to adverse graft outcomes. The aim of this study was to determine whether adherence to immunosuppressant medications changes during transition from a pediatric to an adult program within the same transplant center.
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Making the case for the development of a vaccination against Hepatitis E virus
Liver International (login required)
Hepatitis E virus (HEV) infection is a global problem that affects 20 million individuals, and cause acute hepatitis in 3.5 million, with approximately 70,000 deaths worldwide. While the acute disease is generally self-limited, however, it may progress to fatal fulminant liver failure in certain individuals. Contaminated water supplies disseminate this virus through the fecal-oral route, and swine is thought to be its zoonotic reservoir. Attempts have been made to develop effective HEV vaccines, and two candidates have undergone successful clinical trials. In this review, we discuss HEV epidemiology, genotypes, microbiological structure, as well as the most recent advances in vaccination developments.
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Missed last week's issue? See which articles your colleagues read most.

    The management of antibody-mediated rejection in the first presensitized recipient of a full-face allotransplant (American Journal of Transplantation)
Preoperative Cylex assay predicts rejection risk in patients with kidney transplant (Clinical Transplantation)
Recurrence of hepatocellular carcinoma: Importance of mRECIST response to chemoembolization and tumor size (American Journal of Transplantation)
Survey: Education and informed consent about increased risk donor kidneys (Transplant Infectious Disease (login required))
Survey: Impact of repeat testing of living kidney donors within 14 days of the transplant procedure (Transplant Infectious Disease)

Don't be left behind. Click here to see what else you missed.

Organ transplantation for nonresidents of the United States: A policy for transparency
American Journal of Transplantation (login required)
A policy proposal relating to transplantation of deceased donor organs into nonresidents of the United States was jointly sponsored by the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) International Relations and Ethics Committees and approved by the OPTN/UNOS Board in June 2012. The proposal followed prior acceptance by the Board of the definitions of "travel for transplantation" and "transplant tourism" and the introduction in March 2012 of revised data collection categories for transplant candidates who are neither citizens nor residents.
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