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Home    About AST    Education    Meetings & Events    Public Policy    Contact Us   June 13, 2014

 



Quantifying the risk of incompatible kidney transplantation:
A multicenter study

American Journal of Transplantation
Incompatible live donor kidney transplantation (ILDKT) offers a survival advantage over dialysis to patients with anti-HLA donor-specific antibody (DSA). Program-specific reports (PSRs) fail to account for ILDKT, placing this practice at regulatory risk. Researchers collected DSA data, categorized as positive Luminex, negative flow crossmatch (PLNF), positive flow, negative cytotoxic crossmatch (PFNC) or positive cytotoxic crossmatch (PCC), from 22 centers.
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SOCIETY NEWS


Do You Believe in Miracles?
AST
The AST is featured in the USA Today supplement that hits stands today. AST President, Dr. Daniel Salomon, wrote the forward for the publication entitled, Do you believe in miracles?, which discusses the importance of providing funding for transplantation research. Consider picking up a copy if you are in New York, Dallas, Chicago, Los Angeles, Atlanta, or Philadelphia.
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AST Board of Directors online elections now open
AST
Eligible AST members are encouraged to cast their votes for the AST Board of Directors, as well as various bylaw revisions. The voting site will prompt you to log in to the AST website where you will find more detailed information. Usernames and passwords were sent to eligible members earlier this week. Your vote is requested by 5:00 PM Pacific time on July 29, 2014. Election results will be shared at the AST Town Hall meeting during the World Transplant Congress (WTC) on Tuesday, July 29, at 5:45 PM in the second Floor Foyer of the Moscone West Convention Center. Email Caitlin Frontino, AST director of membership, with questions.
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Just two weeks left to submit your abstract: Due June 29
AST
ESOT + AST Joint Meeting
Personalized Transplantation: From New Diagnostics to New Therapeutics

October 17-19, 2014
Madrid, Spain

Be a part of the program!
Submit your clinical, translational and basic abstracts on Novel Immune Monitoring and/or Diagnostics and Immunosuppression Strategies. Join the ESOT and AST as together we explore:
  • New Options to Improve Immunosuppressive Therapy: Belatacept, Anti CD40 trial (ASKP1240), Anti- IL-6 and Tacrolimus formulations
  • Novel Diagnostics: Donor DNA - Biomarker of Graft Injury, In vivo Live Imaging of the Immune Response and Tolerance Profile
  • Novel Targets for Immunosuppression: B-cells, Plasma Cells and Complement
  • Personalized Medicine: Technique and Technology: Sequencing for TCR Repertoire, Pharmacogenetics, Epigenetics, and Mixed Chimerism
  • Cellular Strategies to Optimize Long Term Outcomes: T-regs, Mesenchymal Cells, Facilitator Cells

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AST's New Education Website
AST
Find the educational content you need quickly and easily on the reorganized education page of the AST website. Find archives of past webinars and journal clubs, along with links to guidelines, directories, and other resources. Also, remember to register for AST's next journal club on June 24: "A committed precursor to innate lymphoid cells", Tues., June 24, register online.
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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


UPCOMING EVENTS IN TRANSPLANTATION


UNOS Primer: Building on Basics, October 27-28, 2014
AST
The UNOS Primer will be held in Richmond, Virginia on October 27-28, 2014 and the UNOS Primer Promotional Agenda is now available for viewing. Sessions are divided into transplant center (TXC) and organ procurement organization (OPO) professional pathways. To encourage professionals with all levels of experience to attend, breakout sessions are listed as 101 (foundational early career knowledge) and 201 (deeper experienced career knowledge).

Registration for the UNOS Primer is now open, please visit the UNOS Primer website on Transplant Pro for more information.

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Check out the AST Events Calendar
AST
The events calendar at www.myAST.org posts a comprehensive listing of industry and transplantation events and meetings, all in one convenient place. Plan ahead with the AST Events Calendar.
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TRANSPLANT NEWS


Bayesian methods for assessing transplant program performance
American Journal of Transplantation (login required)
Based on recommendations from a recent consensus conference and a report commissioned by the Centers for Medicare & Medicaid Services to the Committee of Presidents of Statistical Societies, the Scientific Registry of Transplant Recipients (SRTR) plans to adopt Bayesian methods for assessing transplant program performance. Current methods for calculating program-specific reports (PSRs) often generate implausible point estimates of program performance, wide confidence intervals and underpowered conventional statistical tests. Although technically correct, these methods produce statistical summaries that are prone to misinterpretation.
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New UNOS/OPTN Pancreas Allocation Policy Information
AST
UNOS has released a podcast to prepare transplant professionals for the new pancreas allocation system being implemented this fall. Please visit the UNOS/OPTN Information and Resources section of the AST website to read more and be directed to additional resources.
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Diarrhea caused by viruses in transplant recipients
Transplant Infectious Disease (login required)
Diarrhea is a common complication after solid organ transplantation, and viruses are emerging as important but underestimated causative agents. Viral infections in solid organ transplant (SOT) recipients can result in severe and prolonged diarrhea with significant patient morbidity and graft complications. Cytomegalovirus remains the most common of the viruses to cause diarrhea, but other viruses are being increasingly recognized, including norovirus, rotavirus, and adenovirus.
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First-in-human study of the safety, efficacy of TOL101 induction to prevent kidney transplant rejection
American Journal of Transplantation (login required)
TOL101 is a murine IgM mAb targeting the αβ TCR. Unlike other T cell targets, the αβ TCR has no known intracellular signaling domains and may provide a nonmitogenic target for T cell inactivation. Researchers report the 6-month Phase 2 trial data testing TOL101 in kidney transplantation. The study was designed to identify a dose that resulted in significant CD3 T cell modulation, to examine the safety and tolerability of TOL101 and to obtain preliminary efficacy information.
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Impact of repeat testing of living kidney donors within 14 days of the transplant procedure: A multicenter retrospective survey
Transplant Infectious Disease (login required)
A transmission of human immunodeficiency virus (HIV) from a live kidney donor prompted recommendations by the New York State Department of Health and the U.S. Centers for Disease Control and Prevention that all live donors undergo additional screening for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) within 7–14 days of the donation procedure. There are concerns that re-screening will result in delays and cancelled transplants.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Was Sarah Murnaghan treated justly? (Pediatrics)
Polyclonal antithymocyte globulin and cardiovascular disease in kidney transplant recipients (Journal of the American Society of Nephrology)
Kidney transplantation with early corticosteroid withdrawal: Paradoxical effects at the central and peripheral skeleton (Journal of the American Society of Nephrology)
Malignancy-related mortality following kidney transplantation is common (Kidney International)

Don't be left behind. Click here to see what else you missed.
 



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