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Living donor versus deceased donor liver transplantation: A surgeon-matched comparison of recipient morbidity and outcomes
NCBI
Informed consent for living donor liver transplantation (LDLT) requires that patients are provided with accurate information on the relative benefits and risks of this procedure compared with deceased donor liver transplantation (DDLT). There is strong evidence to suggest that LDLT facilitates timely transplantation to patients; however, information on the relative morbidity and death risks after LDLT as compared with DDLT is limited. A matched cohort comparison was performed matching recipients for age, MELD, date of transplant, gender, primary diagnosis and recipient surgeon.
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SOCIETY NEWS


Save the date for AST's Cutting Edge of Transplantation 2014
Are we on the right track with new drugs and biologics? Have the targets changed? Where can we really impact outcomes with "technology-omics?" The time has come to integrate our strategies, therapies and technology and critically assess their merits as we face the enormous task of extending transplant survival. Save the date for the 2014 AST Cutting Edge of Transplantation, where expert clinicians, leading diagnosticians and world class scientists will address this enormous challenge together with an engaged audience.
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Register now for the AST Fellows Symposium on Transplantation Medicine!
The AST Fellows Symposium will be held Sept. 20-22 in Grapevine, Texas. The AST Fellows Symposium offers an in-depth and interactive study of both clinical transplantation and basic transplant immunobiology, while offering unparalleled access to expert faculty.

Registration and travel grant requests must be received by Wednesday, July 31. View the full registration and travel grant eligibility requirements and register here. This activity has been approved for 15.0 AMA PRA Category 1 Credits™.

For information about the accreditation of this program, contact Global at 303-395-1782 or at a inquire@globaleducationgroup.com.

This activity is jointly sponsored by Global Education Group and American Society of Transplantation.

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PRODUCT SHOWCASE
  University of Utah - Multi-Organ Transplant Surgeon
The University Of Utah Department Of Surgery is seeking applications for a faculty member to join the multi-organ transplant team at the assistant professor level. This is an opportunity to join an expanding program and a cohesive group of transplant surgeons focused on excellence. The candidate should be board certified in general surgery and have completed an ASTS approved transplantation surgery fellowship. Apply here
 


AST offers free webinars live and on demand
AST's Timely Topics in Transplantation webinar series is available free to members 24/7 online. Newly-added webinars include "DSA: New Concerns and New Therapies," "New Strategies in Hepatitis Management," and "Meeting the Challenges of Resistance." AST's Business of Transplantation webinar series consists of live monthly webinars available in archive format shortly after the air date. To see the May and June broadcast dates, or view archived broadcasts, click here.
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TRANSPLANT NEWS


Organ scarcity's the real transplant dilemma
The News Tribune
A Pennsylvania family's legal fight to get a lung transplant for Sarah Murnaghan, a 10-year-old with cystic fibrosis, ultimately proved successful. She is now recuperating after receiving adult lungs that under federal rules wouldn't have been available to her because of her age. Sarah's story has a happy ending. But medical ethicists are rightly concerned about health decisions being made by a judge rather than by transplant experts.
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Human hepatic stellate cells inhibit T-Cell response through B7-H1 pathway
NCBI
The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. It has been shown that potent immunoregulatory activity of hepatic stellate cells (HSCs) in mice. The aim of this study was to examine the immunoregulatory activity of human HSCs.
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Postoperative respiratory management in living donor lobar lung transplantation
Clinical Transplantation (login required)
In a recent study, researchers evaluated postoperative respiratory management of living donor lobar lung transplantation (LDLLT). Perioperative variables were reviewed in 21 patients who underwent LDLLT. Recipients were kept intubated for at least two days after LDLLT to maintain optimal expansion of the implanted lobes.
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Safety and efficacy of sorafenib for the treatment of recurrent hepatocellular carcinoma after liver transplantation
NCBI
Recurrent hepatocellular carcinoma (HCC) following liver transplantation (LT) carries a poor prognosis. The aim of a recent study was to assess the safety and efficacy of sorafenib in patients with recurrent HCC following LT.
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Comparable graft and patient survival in lean and obese liver transplant recipients.
NCBI
Obesity is among the great health problems facing Americans today. More than 32 percent of the United States population is considered obese based on a Body Mass Index (BMI) exceeding 30 kg/m2 . Obesity increases the risk for numerous perioperative complications; but how obesity affects the outcome of liver transplantation remains unclear.
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Lab-grown organs might be solution to transplant woes
New York Daily News
Scientists hope that custom-made organs will allow for quicker, safer transplants. Five-year-old Angela Irizarry's life was saved by a blood vessel built in a lab and researchers believe this is just the tip of the iceberg.
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Poorer dialysis patient survival linked to impaired taste
Renal & Urology News
Altered taste perception is common among hemodialysis (HD) patients, and it is independently associated with poorer markers of nutritional status and increased risk of death, according to a new study. Dr. Steven M. Brunelli of Brigham and Women's Hospital in Boston, and colleagues analyzed data from 1,745 participants in the Hemodialysis Study. In that study, investigators assessed taste perception at baseline and then annually. Patients with end-stage renal disease (ESRD) are at increased risk for taste perception impairment. Although the mechanism for this impairment is not well understood, it is thought to be a consequence of uremia, the authors noted. Another possibility is that zinc deficiency, which is common because of high dialytic removal.
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FDA backs away from new fecal transplant rules
NBC News
The Food and Drug Administration has backed away from new rules requiring doctors to treat human stool as an unapproved drug, meaning fecal transplants used to treat life-threatening gut infections can continue as planned in the U.S. FDA officials said that the agency will not enforce new requirements to obtain investigational new drug applications, or INDs, before doctors can perform the procedure that uses doses of donor stool to repopulate infected colons with healthy bacteria.
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Epstein-Barr virus reactivation in allogeneic stem cell transplantation is highly related to cytomegalovirus reactivation
Clinical Transplantation (login required)
Monitoring of Epstein–Barr virus (EBV) load and pre-emptive rituximab is an appropriate approach to prevent post-transplant lymphoproliferative disease (PTLD) occurring after hematopoietic stem cell transplantation (HSCT). This pre-emptive approach, based on EBV-DNA monitoring through a quantitative polymerase chain reaction, was applied to 101 consecutive patients who underwent allo HSCT at our Institute (median age 50).
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Pretransplant and posttransplant treatment of hepatitis C virus infection with protease inhibitors
Current Opinion in Organ Transplantation (login required)
Antiviral therapy with protease inhibitors will substantially increase the number of patients achieving sustained hepatitis C virus eradication, either before or after liver transplantation. However, side effects and drug–drug interactions will possibly hamper their applicability in both settings; thus, a careful selection and management of patients will be crucial. In the near future, combination of direct-acting antivirals will allow shorter, safer, and more effective IFN-free regimens.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    UDiscarded human kidneys as a source of ECM scaffold for kidney regeneration technologies (NCBI)
Trial: Tacrolimus plus mycophenolate mofetil vs. cyclosporine plus everolimus in deceased donor kidney transplant recipients (Clinical Transplantation)
Plasmacytoid dendritic cells: No longer an enigma and now key to transplant tolerance? (American Journal of Transplantation)

Don't be left behind. Click here to see what else you missed.


Ethnicity, medical insurance, and living kidney donation
Clinical Transplantation (login required)
A recent study examined relationships between race/ethnicity, recipient medical insurance, and living donor kidney transplantation (LKT). Associations between medical insurance and LKT were assessed in 447 recipients at a southeastern US transplant center. Primary and secondary payers were included in the analyses.
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