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New AST blog post: Regenerative Medicine in the White House
AST
The lack of donor organs remains the principal limitation to the field of transplantation. In 2014, wait-listed patients exceeded donors by almost tenfold. As the field of regenerative medicine advances, bioengineered tissues and organs could one day help close this gap. It’s a positive sign that the White House OSTP has expressed interest in supporting research in this area.
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AST Fellows Symposium - Registration now open!
AST
The AST Fellows Symposium on Transplantation is the premier meeting for those entering the exciting field of solid organ transplantation. Special Announcement: Travel grants are now an AST member benefit. Travel grants are only awarded to attendees who are sponsored by an AST member in good standing. Each AST member may sponsor up to two attendees: one from the member’s institution, and one from another institution. For more information on registration eligibility and travel grants, please visit www.myAST.org/Fellows.
AST representatives attend OPTN/UNOS Educational Public Forum on Redesigning Liver Distribution
AST
Representatives from both AST leadership and staff attended the OPTN/UNOS Educational Public Forum on Redesigning Liver Distribution on June 22 in Chicago. Forum participants heard reports from several subcommittees formed after the September 2014 Forum to consider additional data and seek consensus on topics including the finances of broader sharing, logistics and transportation, the metrics of disparity, and optimization of donor liver distribution. An alternative to the OPTN/UNOS redistricting concept was also shared for consideration by Forum attendees.
The AST will continue to remain engaged in these discussions through its Liver Redistricting Task Force. To view the agenda and slides presented at this meeting, please visit: http://optn.transplant.hrsa.gov/news/liver-public-forum-on-june-22-2015-view-presentations/.
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AST TIRN research grant request for proposals now open
AST
The AST Transplantation and Immunology Research Network (TIRN) research grants program seeks to support fellows, junior faculty, and allied health professionals by funding innovative research in basic, clinical, and translational science. A limited number of grants will be awarded for research projects beginning July 1, 2016. The request for proposals is open now at www.TIRN.org/funding. Applications must be completed by 11:59 PM Pacific Standard Time on Sunday, Nov. 1, 2015. For more information, visit www.TIRN.org or email TIRN@myAST.org.
Education and Clinical Tools for the Independent Living Donor Advocate: Webinar July 15
AST
"Living Kidney Donation A to Z: Understanding the Basics" is the next webinar in the Education and Clinical Tools for the Independent Living Donor Advocate (ILDA) webinar series, and takes place Wednesday, July 15 at 1 p.m. EDT. The entire nine-webinar series developed by the AST Live Donor Community of Practice is free to AST members and their associates - just register with an AST member username and password at www.myAST.org/ILDA.
Non-members can purchase access to all nine webinars for just $200. Eligible non-members can join the AST as a non-doctoral member and the webinar series is included in their $90 annual dues. Find out more at www.myAST.org/ILDA.
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The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
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QAPI Adverse Events: Webinar July 8
AST
Join us and ASTS on Wednesday, July 8 at Noon ET for the fifth installment of a monthly webinar series designed and presented by the Centers for Medicare and Medicaid Services. This webinar provides an in-depth review of what Adverse Events are and how Adverse Events can be identified, documented, and acted upon in order to prevent future re-occurrences. Register today!
The content of this presentation is determined independently by CMS without input or endorsement from either the ASTS or AST. Both societies appreciate CMS providing this information to the transplant community and are pleased to facilitate that process.
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UPCOMING EVENTS IN TRANSPLANTATION
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AST Fellows Symposium - Registration now open!
AST
Sept. 25-27, 2015 | Grapevine, TX
For more information: www.myAST.org/fellows.
ASHI 41st Annual Meeting
ASHI
Sept. 28 - Oct. 2, 2015 | Savannah, GA
For more information: http://www.ashi-hla.org/events/annual-meeting/
2015 Banff/CST Joint Meeting
CST
Oct. 5-10, 2015 | Vancouver
For more information: http://www.cst-transplant.ca/meetings_asm.html
PRODUCT SHOWCASE
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VTI’s disposable intraoperative Doppler probes are ready to verify technical results.
There’s no longer the need to perform sterilization that frequently causes irreversible damage to the traditional Doppler probes.
Advantages include fewer replacements of conventional Doppler probes damaged during sterilization, OR time saved, and a reduction in specialty procedures.
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Transmission of hepatitis C virus from organ donors despite nucleic acid test screening
American Journal of Transplantation
Nucleic acid testing (NAT) for hepatitis C virus (HCV) is recommended for screening of organ donors, yet not all donor infections may be detected. We describe three US clusters of HCV transmission from donors at increased risk for HCV infection. Donor's and recipients' medical records were reviewed. Newly infected recipients were interviewed. Donor-derived HCV infection was considered when infection was newly detected after transplantation in recipients of organs from increased risk donors.
Hyperlipidemia alters regulatory T cell function and promotes resistance to tolerance induction through costimulatory molecule blockade
American Journal of Transplantation
Recent work from our laboratory has shown that hyperlipidemia promotes accelerated rejection of vascularized cardiac allografts in mice by inducing anti-donor Th17 reactivity and production of IL-17. Here, we show that hyperlipidemia also affects FoxP3+ regulatory T cells (Tregs).
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Raptor's mission is to develop and commercialize life-altering therapeutics that treat rare, debilitating, and often fatal diseases.
LEARN MORE
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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Right ventricular failure after implantation of continuous flow left ventricular assist device (LVAD): Analysis of predictors and outcomes
Clinical Transplantation
Post-operative right ventricular failure is a serious complication for up to 50% of patients following LVAD insertion. Predicting RV failure is an important factor for patients as planned BIVAD support has been shown to correlate to better outcomes compared to delayed BIVAD to LVAD conversion.
New York has a liver problem, with no easy solution
Capital
Scott Yocom was dying when his doctors at Mount Sinai suggested there was nothing more they could do for him in New York City.
If he wanted to live, they said, his best chance was to fly to Cleveland. The 45-year-old architect had two decades earlier been diagnosed with Sclerosing cholangitis, a progressive disease that destroys the bile ducts inside and outside the liver. Mount Sinai has a world-class transplant team. What they don't have are organs.
Increasing the number of organ transplants in the United States by optimizing donor authorization rates
American Journal of Transplantation
While recent policies have focused on allocating organs to patients most in need and lessening geographic disparities, the only mechanism to increase the actual number of transplants is to maximize the potential organ supply. We conducted a retrospective cohort study using OPTN data on all “eligible deaths” from 1/1/08 to 11/1/13 to evaluate variability in donor service area (DSA)-level donor authorization rates, and to quantify the potential gains associated with increasing authorization rates.
Missed last week's issue? See which articles your colleagues read most.
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