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Home    About AST    Education    Meetings & Events    Public Policy    Contact Us   June 27, 2014


OPTN/UNOS Releases Concept Document on Alternatives for Liver Allocation
Last week, the OPTN/UNOS released a concept document and questionnaire to seek input on issues being studied by their Liver and Intestinal Organ Transplantation Committee, including potential liver allocation redistricting as an alternative to current distribution areas. The questionnaire is meant to identify topics for further study and discussion at a public forum, which is likely to occur in September.

AST members are encouraged to individually evaluate the document and submit comments directly to UNOS. The deadline to complete the questionnaire is July 11, 2014. Any questions should be directed to your UNOS Regional Administrator. We hope that you will take the time to provide input on this important topic.
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Remembering AST Members at WTC
AST members who have passed away during the past year will be honored at the WTC through a short tribute during the Town Hall meeting. If you know of any AST members who should be included in this memorial process, please send us the following information:

Member name
Most recent professional position and institution
Picture (optional)

This information should be emailed to no later than Tuesday, July 1, 2014.

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Only three days left! Abstract deadline is Sunday, June 29
ESOT + AST Joint Meeting
Personalized Transplantation: From New Diagnostics to New Therapeutics

October 17-19, 2014
Madrid, Spain

Join the ESOT and AST in Madrid as we explore:
  • New Options to Improve Immunosuppressive Therapy: Belatacept, Anti CD40 trial (ASKP1240), Anti- IL-6 and Tacrolimus formulations
  • Novel Diagnostics: Donor DNA - Biomarker of Graft Injury, In vivo Live Imaging of the Immune Response and Tolerance Profile
  • Novel Targets for Immunosuppression: B-cells, Plasma Cells and Complement
  • Personalized Medicine: Technique and Technology: Sequencing for TCR Repertoire, Pharmacogenetics, Epigenetics, and Mixed Chimerism
  • Cellular Strategies to Optimize Long Term Outcomes: T-regs, Mesenchymal Cells, Facilitator Cells
Submit your clinical, translational and basic abstracts this weekend on Novel Immune Monitoring and/or Diagnostics and Immunosuppression Strategies.

Education on demand at
Find the educational content you need quickly and easily on the reorganized education page of the AST website. Find archives of past webinars and journal clubs, along with links to guidelines, directories, and other resources.

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AST Board of Directors online elections now open
Eligible AST members are encouraged to cast their votes for the AST Board of Directors, as well as various bylaw revisions, at The voting site will prompt you to log in to the AST website where you will find more detailed information. Usernames and passwords were sent to eligible members earlier this week. Your vote is requested by 5:00 PM Pacific time on July 29, 2014.
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Registration now Open for the AST 2014 Fellows Symposium
September 19-21, 2014
Grapevine, Texas

Don't miss this highly popular educational meeting for young professionals starting a career in transplantation or immunology! The AST Fellows Symposium features an in-depth and interactive study of clinical transplantation, basic transplant immunobiology, and translational science in an informal setting, while providing important insights into career development and exceptional access to expert faculty. A limited number of travel grants are available for clinical and research fellows, and residents and trainees with an interest in solid organ transplantation. Register now!

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RSVP for the AST Town Hall Meeting & Excellence in Transplantation Reception at the 2014 WTC
AST members are invited to take part in the annual member's business meeting, delivered in an exciting interactive town hall format. The Town Hall will take place during the upcoming World Transplant Congress (WTC) on Tuesday, July 29, 2014 at 5:45 PM on the 2nd floor foyer of the Moscone West Convention Center. Join your colleagues and AST leadership to discuss the challenges and opportunities in the field of transplantation, learn how AST is positioned to meet these challenges/opportunities, and provide your feedback in shaping the future of the AST.

Immediately following the town hall, enjoy a casual gathering at the AST Excellence in Transplantation Reception, also on the 2nd floor foyer of the Moscone West Convention Center. Indulge in delectable libations and hors d'oeuvres as you mingle with friends, award and grant recipients, and supporters.

To submit your R.S.V.P. to attend both the town hall and reception, click here. Should you have any questions, please do not hesitate to contact the AST staff at or (856) 439-9986.

We look forward to seeing you in San Francisco!

These events made possible in part by Sanofi and Veloxis Pharmaceuticals

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Raptor's mission is to develop and commercialize life-altering therapeutics that treat rare, debilitating, and often fatal diseases.
Advertise here!

To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.


OPTN/UNOS Board approves initial policies regarding limb and face transplantation, new policies for pediatric heart allocation
The OPTN/UNOS Board of Directors, at its meeting June 23 and 24, unanimously approved the first national policies and standards for transplantation of limbs, faces and other structures collectively known as vascularized composite allografts (VCAs). The requirements will be in effect for 15 months, allowing the transplant network during that time to seek public comment regarding potential improvements.
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Graft vessel disease following heart transplantation: A systematic review of the role of statin therapy
World Journal of Surgery (login required)
Graft vessel disease (GVD) is a significant cause of morbidity and mortality in cardiac allograft recipients. Hyperlipidemia is a risk factor for GVD, and the majority of patients will display abnormal lipid profiles in the years following transplant. This systematic review aims to establish the clinical impact of statins in cardiac allograft recipients, critically appraising the literature on this subject.
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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE

Optical coherence tomography for the evaluation of asymmetric cardiac allograft vasculopathy in a child
Pediatric Transplantation (login required)
Researchers present an unusual case of cardiac allograft vasculopathy in a child with isolated disease in the LAD coronary artery. Initial progression of the disease appeared to have been halted by the use of sirolimus, but the assessment of disease in other vessels (particularly the RCA) was of particular importance in deciding whether or not to relist this patient for transplantation. Due to the known limitations of coronary angiography, researchers used OCT to assess for angiographically silent CAV. The normal intravascular appearance of the RCA by OCT was reassuring, and the child was not relisted for transplantation. OCT offers multiple advantages for the assessment of CAV in children.
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An analysis of pancreas transplantation outcomes based on age groupings — an update of the UNOS Database
Clinical Transplantation (login required)
Previously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single center reports. A UNOS database review of all adult pancreas and kidney-pancreas transplants between 1996 and 2012 was performed in the following.
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Preconception counseling, fertility, and pregnancy complications after abdominal organ transplantation: A survey and cohort study of 532 recipients
Clinical Transplantation (login required)
Pregnancy after solid organ transplant is a significant priority for transplant recipients but how patients report being counseled is unknown. Researchers performed a single-center retrospective cohort study and telephone survey of female patients ages 18-49 at time of kidney, pancreas, or liver transplant from 2000-2012. Data on pregnancy counseling, fertility, and maternal, fetal and transplant-specific outcomes were collected.
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The perioperative management of patients undergoing combined heart-liver transplantation
Transplantation (login required)
Combined heart-liver transplantation (CHLT) is an uncommonly performed procedure for patients with coexisting cardiac and liver disease. A retrospective review was performed of patients undergoing CHLT at our institution from 1999 to 2013. Information related to preoperative organ function, intraoperative management, surgical approach, transfusions, postoperative findings, and 30-day mortality was reviewed.
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Missed last week's issue? See which articles your colleagues read most.

    Frailty predicts waitlist mortality in liver transplant candidates
(American Journal of Transplantation)
Late antibody-mediated rejection in renal allografts: Outcome after conventional
and novel therapies
New blood test may help detect heart transplant rejection
(HealthDay News via U.S. News & World Report)
Impact of anti-thymocyte globulin during immunosuppression induction
in patients with hepatitis C after liver transplantation
(Digestive Diseases and Sciences)

Don't be left behind. Click here to see what else you missed.

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