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Obesity and its impact on transplantation and alloimmunity
Transplantation (login required)
Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.
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SOCIETY NEWS


Register now for the AST Fellows Symposium on Transplantation Medicine!
The AST Fellows Symposium will be held Sept. 20-22 in Grapevine, Texas. The AST Fellows Symposium offers an in-depth and interactive study of both clinical transplantation and basic transplant immunobiology, while offering unparalleled access to expert faculty.

Registration and travel grant requests must be received by Wednesday, July 31. View the full registration and travel grant eligibility requirements and register here. This activity has been approved for 15.0 AMA PRA Category 1 Credits™.

For information about the accreditation of this program, contact Global at 303-395-1782 or at inquire@globaleducationgroup.com.

This activity is jointly sponsored by Global Education Group and American Society of Transplantation.


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PRODUCT SHOWCASE
  University of Utah - Multi-Organ Transplant Surgeon
The University Of Utah Department Of Surgery is seeking applications for a faculty member to join the multi-organ transplant team at the assistant professor level. This is an opportunity to join an expanding program and a cohesive group of transplant surgeons focused on excellence. The candidate should be board certified in general surgery and have completed an ASTS approved transplantation surgery fellowship. Apply here
 


Save the date for AST's Cutting Edge of Transplantation 2014
Optimizing Long-term Transplant Survival: Therapeutics, Targets and Technologies
Come to Arizona next February for the AST's Cutting Edge of Transplantation where expert clinicians, leading diagnosticians and world class scientists will address this enormous challenge together with an engaged audience. Topics include: Organ preservation and injury prevention, chronic injury and tolerance, immunosuppression, inflammation and fibrosis as targets, microbiomes, senescence and omics in the clinic. Abstract submission will open later this summer.

When: Feb. 13-16, 2014
Where: Sheraton Wild Horse Pass, Chandler, Ariz.

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Free webinars for AST members
AST's Timely Topics in Transplantation webinar series is available free to members 24/7 online Webinars include "DSA: New Concerns and New Therapies," "New Strategies in Hepatitis Management," and "Meeting the Challenges of Resistance." The AST's Business of Transplantation live webinar series has concluded, but all eight webinars are available in archive format.
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TRANSPLANT NEWS


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Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent
Transplantation (login required)
In renal allograft recipients presenting with graft dysfunction, it is critical to determine the patency of the transplant vasculature to guide clinical management. Conventional modalities such as Doppler ultrasound, contrast-enhanced computed tomography, magnetic resonance angiography (MRA), and noncontrast MRA are each of limited use because of technical factors and toxicity of standard contrast agents. The purpose of this study was to retrospectively review institutional experience with renal transplant MRA using ferumoxytol (a nonnephrotoxic medication) as a contrast agent and evaluate its use in the assessment of allograft vascular patency in patients with graft dysfunction, either delayed or slow graft function within hours to days after kidney transplantation or acute kidney injury weeks to months after kidney transplantation.
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Dialysis patient coronary artery disease burden rising, mortality declining
Renal & Urology News
Coronary artery disease (CAD) is on the rise among U.S. dialysis patients, but mortality rates are declining, new findings show. Dr. Austin G. Stack of the University of Limerick in Limerick, Ireland, and colleagues analyzed data from 823,753 incident dialysis patients and found that the annual prevalence of CAD at dialysis initiation increased significantly from 23.7 percent in 1995 to 27.6 percent in 2004, according to a report in the American Journal of Nephrology.
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Early pancreas allograft thrombosis
Clinical Transplantation (login required)
To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. Researchers hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT.
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Missed last week's issue? See which articles your colleagues read most.

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Donor-specific antibodies: Can they predict C4d deposition in pediatric heart recipients?
Pediatric Transplantation (login required)
There is limited evidence regarding the utility of circulating DSA in surveillance for AMR of pediatric heart recipients. It has been hypothesized that quantitation of DSA improves their power for predicting a C4d+, an integral component in the current diagnostic criteria of AMR.
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Gene test may ID kidney rejection
MedPage Today (login required)
A urine-derived three-gene signature showed potential for noninvasive discrimination of kidney grafts that are being rejected from those that are not, a study of almost 500 kidney recipients showed
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