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SOCIETY NEWS


Optimizing Immunosuppression in Liver Transplant Patients - On Demand Webinar
AST
The AST Liver and Intestinal Community of Practice has developed a four part, on demand webinar exploring more personalized approaches to immunosuppression and the data that support the implementation of these approaches. The webinar is broken into four 15-20 minute segments so you can watch each segment at your leisure. Visit www.myast.org/webinars to access the webinar.
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Registration open for ASN Kidney Week and 'Early Program' on transplantation
AST
In recent years, there have been important advances in the field of kidney transplantation that will impact the care of the kidney transplant recipient. ASN, in cooperation with AST, has developed a program providing an interactive, case-based overview of exciting advances in kidney transplantation, with a focus upon specific populations, complications, and ethical issues. Nephrologists with an interest in transplantation, transplant physicians, and trainees in the nephrology are encouraged to attend this program. Get full program details and register here.
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AST at WTC


AST Town Hall Meeting & Reception: Many voices, one goal
AST
AST members are invited to attend a Town Hall meeting at the upcoming World Transplant Conference (WTC) on Tuesday, July 29 at 5:45 PM on the second floor foyer of the Moscone West Convention Center. The Town Hall will provide a forum for open discussion between the membership and the leadership about key issues impacting the Society and field of transplantation, and how the Society is positioned to address those key issues. In addition, we'll announce the Board of Directors election results, recognize and honor AST volunteer leadership, and award the 2014 research grants.

Immediately following the town hall, enjoy a casual gathering at the AST Excellence in Transplantation Reception, also on the second floor foyer of the Moscone West Convention Center. Indulge in delectable libations and hors d'oeuvres as you mingle with friends, award and grant recipients, and supporters.

To submit your R.S.V.P. to attend both the town hall and reception, click here. Should you have any questions, please do not hesitate to contact the AST staff at info@myAST.org or (856) 439-9986.

We look forward to seeing you in San Francisco!

These events made possible in part by Dompé, Sanofi and Veloxis Pharmaceuticals

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UPCOMING EVENTS IN TRANSPLANTATION


Only five days left to register for the AST 2014 Fellows Symposium
AST
September 19-21, 2014
Grapevine, Texas

Join us this September for the AST Fellows Symposium, a highly popular educational meeting for young professionals starting a career in transplantation or immunology. Featuring an in-depth and interactive study of clinical transplantation, basic transplant immunobiology, and translational science in an informal setting, the Fellows Symposium provides important insights into career development and exceptional access to expert faculty. A limited number of travel grants are available for clinical and research fellows, and residents and trainees with an interest in solid organ transplantation. Register now!

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Register early to receive a discounted rate!
AST
ESOT + AST Joint Meeting
Personalized Transplantation: From New Diagnostics to New Therapeutics
Oct. 17-19, 2014 Madrid, Spain

Register by September 7 and save! Join the ESOT and AST in beautiful Madrid, Spain as together we explore:
  • New Options to Improve Immunosuppressive Therapy
    Belatacept, Anti CD40 trial (ASKP1240), Anti- IL-6 and Tacrolimus formulations
  • Novel Diagnostics
    Donor DNA - Biomarker of Graft Injury, In vivo Live Imaging of the Immune Response and Tolerance Profile
  • Novel Targets for Immunosuppression
    B-cells, Plasma Cells and Complement
  • Personalized Medicine: Technique and Technology
    Sequencing for TCR Repertoire, Pharmacogenetics, Epigenetics and Mixed Chimerism
  • Cellular Strategies to Optimize Long Term Outcomes
    T-regs, Mesenchymal Cells, Facilitator Cells

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COMMITMENT TO CARE
Raptor's mission is to develop and commercialize life-altering therapeutics that treat rare, debilitating, and often fatal diseases.
LEARN MORE
Advertise here!

To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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Save the Date for the Cutting Edge of Transplantation
Immunity and Inflammation: Engineering Cell, Gene, and Drug Therapies

AST
February 5-7, 2015
Sheraton Wild Horse Pass – Chandler, AZ

Make plans to attend this high-energy, intimate meeting featuring sessions on:

  • A Critical Review of Cell Therapies
  • Whatever Happened to Gene Therapy?
  • Organ Repair and Regeneration, and Organ Generation
  • Drug Development and Rediscovering Pathways
  • In vitro, In vivo, and In silico: Are We Done with Animal Models?

Website and call for basic, clinical and translational abstracts coming soon!

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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


TRANSPLANT NEWS


Biannual Update on UNOS
UNOS and AST
Many changes are happening this year. The biggest change is the implementation of the new Kidney Allocation System. In an effort to keep the AST membership as informed as possible, a section of the website will be dedicated to UNOS updates. We will post information that comes directly from UNOS as well as AST official responses to proposals out for public comment. Look for this new section to the website in August.

All comments are read by UNOS, and committees respond to ALL input, so hearing from our membership is critical. We ask for careful review by appropriate AST committees and communities of practice. Read the UNOS Biannual Update.

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Morbidity and mortality of live lung donation: Results from the RELIVE Study
American Journal of Transplantation (log in required)
The Renal and Lung Living Donors Evaluation Study assesses outcomes of live lung (lobectomy) donors. This is a retrospective cohort study at University of Southern California (USC) and Washington University (WASHU) Medical Centers (1993–2006), using medical records to assess morbidity and national databases to ascertain postdonation survival and lung transplantation. Serious complications were defined as those that required significant treatment, were potentially life-threatening or led to prolonged hospitalization.
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Predictors of hospital length of stay after implantation of a left ventricular assist device: An analysis of the INTERMACS registry
The Journal of Heart and Lung Transplantation (log in required)
Few studies have reported on hospital length of stay (LOS) after left ventricular assist device (LVAD) implantation. The purpose of this study was to determine pre- and peri-operative predictors of hospital LOS after LVAD implantation. Researchers analyzed adult primary continuous-flow LVAD patients implanted between June 23, 2006 and Dec. 31, 2010, at 105 institutions from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Retrospective analyses included measures of central tendency, frequencies, correlations and stepwise multivariable regression modeling.
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MRSA and VRE colonization in solid organ transplantation: A meta-analysis of published studies
American Journal of Transplantation (log in required)
The burden of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) colonization among the increasing number of solid organ transplant patients has not been systematically explored. The authors searched PubMed and EMBASE for pertinent articles, performed a meta-analysis of prevalence across eligible studies and estimated the risk of ensuing MRSA or VRE infections relative to colonization status.
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Chronic hepatitis E in solid-organ transplantation: The key implications
of immunosuppressants

Current Opinion in Infectious Diseases (log in required)
Solid-organ recipients infected with hepatitis E virus (HEV) bear an extremely high risk of developing chronic hepatitis, although this virus only causes acute infection in the general population. Immunosuppressive medication universally used after transplantation to prevent organ rejection appears to be a main risk factor for developing chronic infection. This review aims to overview and emphasize the current clinical and experimental evidence regarding the key implications of immunosuppressants in chronic hepatitis E.
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Pre-operative mortality risk assessment in patients with continuous-flow left ventricular assist devices: Application of the HeartMate II risk score
The Journal of Heart and Lung Transplantation (log in required)
Survival with left ventricular assist device (LVAD) therapy is dependent on appropriate patient selection. The HeartMate II risk score (HMRS) was recently derived and validated to predict 90-day mortality in clinical trial patients with continuous-flow LVADs. The aim of this study was to test HMRS validity in predicting survival at our institution.
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Increasing the tolerance of DCD hearts to warm ischemia by pharmacological postconditioning
American Journal of Transplantation
Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts. We used a porcine asphyxia model to evaluate viability of DCD hearts subjected to warm ischemic times (WIT) of 20-40 minutes prior to flushing with Celsior (C) solution. Researchers then assessed potential benefits of supplementing C with erythropoietin, glyceryl trinitrate and zoniporide (Cs), a combination that we have shown previously to activate ischemic postconditioning pathways.
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Increased use of split-liver transplants can trim waiting lists
By Alan Kelsky
In the United States, transplant lists typically have about 16,000 people waiting for new livers. Each year, 10 percent of that list — 1,600 patients — die before they are chosen. Recent research found that split-liver transplants have the same survival rate after five years as whole-liver surgery. When whole-liver transplants are done, patient size is a factor in who gets the life-saving organ. If the liver comes from a full-sized male adult, the organ is too large for a child or a smaller adult. By using the split-liver technique, one adult and one child benefit from the donor.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Dialysis facility and network factors associated with low kidney transplantation rates
among United States dialysis facilities
(American Journal of Transplantation)
Excess mortality on the liver transplant waiting list: Unintended policy consequences
and MELD Inflation
(Hepatology)
Quantifying the risk of incompatible kidney transplantation: A multicenter study
(American Journal of Transplantation)
Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the AASLD, AST and the NASPGHAN (Hepatology)
Liver transplantation in recipients receiving renal replacement therapy: Outcomes analysis
and the role of intraoperative hemodialysis
(American Journal of Transplantation)

Don't be left behind. Click here to see what else you missed.
 



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Colby Horton, Vice President of Publishing, 469.420.2601
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