Education and Clinical Tools for the Independent Living Donor Advocate: Webinar Aug. 19
AST
"Living Liver Donation A to Z: Understanding the Basics" is the next webinar in the Education and Clinical Tools for the Independent Living Donor Advocate (ILDA) webinar series, and takes place Wednesday, Aug. 19 at 1 p.m. EDT. The entire nine-webinar series developed by the AST Live Donor Community of Practice is free to AST members and their associates, just register with an AST member username and password at www.myAST.org/ILDA.
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QAPI Adverse Events: Webinar Aug. 12
AST
Join us and ASTS on Wednesday, Aug. 12, 2015 at Noon ET for the sixth installment of a monthly webinar series designed and presented by the Centers for Medicare and Medicaid Services. This webinar provides an in-depth review of what a ‘thorough analysis’ should contain, a look at tools and methods that may be utilized and how the results of an analysis may be used to prevent re-occurrences. Register today!
PRODUCT SHOWCASE
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You care about your transplant
patients. And so do we. That’s
why we’re introducing Astellas
Cares—a new program that
offers you customized tools,
educational resources, and
comprehensive support to help
your patients care for their
health. To register, visit
AstellasCares.com/Transplant
today.
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UPCOMING EVENTS IN TRANSPLANTATION
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ASHI 41st Annual Meeting
ASHI
Sept. 28 - Oct. 2, 2015 | Savannah, GA
For more information: http://www.ashi-hla.org/events/annual-meeting/
Surrogate Endpoints for Clinical Trials in Kidney Transplantation; Public Workshop
FDA
Sept. 28, 2015 | Arlington, VA
For more information: http://www.fda.gov/Drugs/NewsEvents/ucm449248.htm
2015 Banff/CST Joint Meeting
CST
Oct. 5-10, 2015 | Vancouver
For more information: http://www.cst-transplant.ca/meetings_asm.html
Transplant Quality Institute (TQI)
Sponsored by AFDT
Oct. 7-9, 2015 | Dallas, TX
For more information: http://www.amfdt.org/
Call for abstracts: http://www.amfdt.org/pdf/2015%20TQI%20Call%20for%20Abstracts.pdf
PRODUCT SHOWCASE
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The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
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Nonchimeric HLA-identical renal transplant tolerance: Regulatory immunophenotypic/genomic biomarkers
American Journal of Transplantation
We previously described early results of a nonchimeric operational tolerance protocol in human leukocyte antigen (HLA)-identical living donor renal transplants and now update these results. Recipients given alemtuzumab, tacrolimus/MPA with early sirolimus conversion were multiply infused with donor hematopoietic CD34+ stem cells. Immunosuppression was withdrawn by 24 months. Twelve months later, operational tolerance was confirmed by rejection-free transplant biopsies.
Planning for uncertainty and fallbacks can increase the number of transplants in a kidney-paired donation program
American Journal of Transplantation
A kidney-paired donation (KPD) pool consists of transplant candidates and their incompatible donors, along with nondirected donors (NDDs). In a match run, exchanges are arranged among pairs in the pool via cycles, as well as chains created from NDDs. A problem of importance is how to arrange cycles and chains to optimize the number of transplants. We outline and examine, through example and by simulation, four schemes for selecting potential matches in a realistic model of a KPD system; proposed schemes take account of probabilities that chosen transplants may not be completed as well as allowing for contingency plans when the optimal solution fails.
First report on the OPTN national variance: Allocation of A2/A2B deceased donor kidneys to blood group B increases minority transplantation
American Journal of Transplantation
In 2002, the Organ Procurement and Transplantation Network (OPTN) Minority Affairs Committee (MAC) implemented a national, prospective, “variance of practice” to allow deceased donor, ABO blood group incompatible, A2 antigen, kidney transplantation into blood group B recipients; outcomes of this cohort were compared to ABO compatible recipients. The goal of the variance was to increase the number of transplants to B candidates without negatively impacting survival or compromising system equity.
PRODUCT SHOWCASE
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VTI’s disposable intraoperative Doppler probes are ready to verify technical results.
There’s no longer the need to perform sterilization that frequently causes irreversible damage to the traditional Doppler probes.
Advantages include fewer replacements of conventional Doppler probes damaged during sterilization, OR time saved, and a reduction in specialty procedures.
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Post-transplantation immunoadsorption can be withheld in ABO-incompatible kidney transplant recipients
Therapeutic Apheresis and Dialysis
After ABO-incompatible kidney transplantation, postoperative plasma exchange (PE) or immunoadsorption (IA) is performed per protocol or depending on postoperative A/B-titers to prevent acute rejection. However, the need for postoperative PE or IA is not known. Since 2006, 30 consecutive patients received three standard postoperative IAs. Starting from 2009, the last 46 patients received only preoperative IA. Preoperative desensitization consisted of rituximab, tacrolimus, mycophenolate mofetil, prednisone and intravenous immunoglobulins.
Changes in risk profile over time in the population of a pediatric heart transplant program
The Annals of Thoracic Surgery via PubMed
Single-center data on pediatric heart transplantation spanning long time frames is sparse. We attempted to analyze how risk profile and pediatric heart transplant survival outcomes at a large center changed over time. We divided 320 pediatric heart transplants done at Stanford University between 1974 and 2014 into three groups by era: the first 20 years (95 transplants), the subsequent 10 years (87 transplants), and the most recent 10 years (138 transplants). Differences in age at transplant, indication, mechanical support, and survival were analyzed.
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