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AST Change of Address
The AST national office is relocating, and the office will be closed on Friday, Aug. 8 during the move. AST staff will be able to assist you on Monday, Aug. 11 from our new office. Our phone system will also be offline on Friday, so you will not be able to leave voice messages. Please make a note of our new address:

1120 Route 73
Suite 200
Mount Laurel, NJ 08054
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OPTN/UNOS Education on KPD Pilot Program and New Living Donor Policy Requirements for Follow-Up Data Reporting
OPTN/UNOS Kidney Paired Donation Pilot Program (KPDPP) Town Hall, Aug. 21, 1-2 p.m. EST

KPDPP participants: Register now and prepare for upcoming policy changes by engaging in Q&A with a panel of subject matter experts.

The Living Liver Donor: New OPTN Policy Requirements for Follow-Up Data Reporting Webinar, Aug. 28, 2-3:15 pm EST

Living Liver Donor Recovery Hospitals: Register now to understand and demonstrate how to successfully submit follow-up data to comply with the new reporting requirements. The new policies go into effect Sept. 1, 2014. The webinar will include a question and answer session with a panel of subject matter experts.

Interested in additional instructional offerings? Please visit the OPTN page of the Health Resources and Services Administration or Transplant Pro for more information.

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Register early to receive a discounted rate!
ESOT + AST Joint Meeting
Personalized Transplantation: From New Diagnostics to New Therapeutics
Oct. 17-19, 2014
Madrid, Spain

Register by Sept. 7 and save!

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Save the Date for the Cutting Edge of Transplantation
Immunity and Inflammation: Engineering Cell, Gene, and Drug Therapies

Feb. 5-7, 2015
Sheraton Wild Horse Pass – Chandler, Ariz.

Make plans to attend this high-energy, intimate meeting featuring sessions on:
  • A Critical Review of Cell Therapies
  • Whatever Happened to Gene Therapy?
  • Organ Repair and Regeneration, and Organ Generation
  • Drug Development and Rediscovering Pathways
  • In vitro, In vivo, and In silico: Are We Done with Animal Models?
Website and call for basic, clinical and translational abstracts coming soon!

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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.


Through a glass darkly: Seeking clarity in preventing late kidney transplant failure
Journal of the American Society of Nephrology
A common lament is that long-term kidney transplant outcomes remain the same despite improvements in early graft survival. To be fair, progress has been made—in both our understanding of chronic injury and modestly, graft survival. However, we are still a long way from actually solving this important and difficult problem. In this review, we outline recent data supporting the existence of several causes of renal allograft loss, the incidences of which peak at different time points after transplantation.
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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE

Big data in organ transplantation: Registries and administrative claims
American Journal of Transplantation
The field of organ transplantation benefits from large, comprehensive, transplant-specific national data sets available to researchers. In addition to the widely used Organ Procurement and Transplantation Network (OPTN)-based registries (the United Network for Organ Sharing and Scientific Registry of Transplant Recipients data sets) and United States Renal Data System (USRDS) data sets, there are other publicly available national data sets, not specific to transplantation, which have historically been underutilized in the field of transplantation.
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Frailty predicts waitlist mortality in liver transplant candidates
American Journal of Transplantation
We aimed to determine whether frailty, a validated geriatric construct of increased vulnerability to physiologic stressors, predicts mortality in liver transplant candidates. Consecutive adult outpatients listed for liver transplant with laboratory Model for End-Stage Liver Disease (MELD) ≥ 12 at a single center (97 percent recruitment rate) underwent four frailty assessments: Fried Frailty, Short Physical Performance Battery (SPPB), Activities of Daily Living (ADL) and Instrumental ADL (IADL) scales.
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Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy
A role for natural killer (NK) cells in cardiac allograft vasculopathy (CAV) was suggested by our earlier observation that CAV arises even in the absence of detectable antidonor T-cell or B-cell reactivity in parental to F1 mouse heart grafts. However, prevention of CAV in this setting required the depletion of both NK and CD4+ T cells.
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Increasing the tolerance of DCD hearts to warm ischemia by pharmacological postconditioning
American Journal of Transplantation
Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts. We used a porcine asphyxia model to evaluate viability of DCD hearts subjected to warm ischemic times (WIT) of 20–40 min prior to flushing with Celsior (C) solution. We then assessed potential benefits of supplementing C with erythropoietin, glyceryl trinitrate and zoniporide (Cs), a combination that we have shown previously to activate ischemic postconditioning pathways.
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Organ transplantation for nonresidents of the United States: A policy for transparency
American Journal of Transplantation
A policy proposal relating to transplantation of deceased donor organs into nonresidents of the United States was jointly sponsored by the Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) International Relations and Ethics Committees and approved by the OPTN/UNOS Board in June 2012. The proposal followed prior acceptance by the Board of the definitions of “travel for transplantation” and “transplant tourism” and the introduction in March 2012 of revised data collection categories for transplant candidates who are neither citizens nor residents.
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Short-term mechanical circulatory support for recovery from acute right ventricular failure: Clinical outcomes
The Journal of Heart and Lung Transplantation
Acute right ventricular failure (ARVF) refractory to optimal medical management may require rescue therapy with mechanical circulatory support (MCS). The RV exhibits a greater capacity for rapid recovery than the left ventricle, making devices designed specifically for temporary RV MCS attractive. We report our experience with the Impella Right Direct (RD) and Right Peripheral (RP) temporary ventricular assist devices (Abiomed, Danvers, MA) in patients with ARVF.
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Missed last week's issue? See which articles your colleagues read most.

    MRSA and VRE colonization in solid organ transplantation: A meta-analysis of published studies (American Journal of Transplantation)
Chronic hepatitis E in solid-organ transplantation: The key implications of immunosuppressants (Current Opinion in Infectious Diseases)
Morbidity and mortality of live lung donation: Results from the RELIVE Study
(American Journal of Transplantation)

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Colby Horton, Vice President of Publishing, 469.420.2601
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Julie Bernhard, Executive Editor, 469.420.2647  
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