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Equal opportunity supplemented by fair innings: Equity and efficiency in allocating deceased donor kidneys
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For seven years, the Kidney Transplantation Committee of the United Network for Organ Sharing/Organ Procurement Transplantation Network has attempted to revise the kidney allocation algorithm for adults (≥18 years) in end-stage renal disease awaiting deceased donor kidney transplants. Changes to the kidney allocation system must conform to the 1984 National Organ Transplant Act which clearly states that allocation must take into account both efficiency (graft and person survival) and equity (fair distribution). In this article, we evaluate three allocation models: The current system, age-matching and a two-step model that we call "Equal Opportunity Supplemented by Fair Innings."

Related article:
  • Fairness and efficiency: Designing a better kidney allocation system (Science Life)
  • More


    Campath Distribution change
    AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Please see the following information regarding Sanofi Oncology's notice of the changing distribution model for Campath (alemtuzumab). This program will be put in place on Sept. 4. Sanofi Oncology is committed to ensuring that patients who need Campath will receive it and Sanofi will provide the product free of charge through the Campath Distribution Program.

    Need a reason to visit the beautiful south of France? Come to the ESOT AST Joint Meeting!
    AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Join us Oct. 12-14 in Nice, France, to witness cutting edge science presented by an international pool of expert speakers. Click here for a personal invitation and more information. Hope to see you there!

    Make the most of your AST membership — join a community of practice
    AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Participation in AST's communities of practice can enhance your member experience. The AST has 12 unique communities of practice which serve our member constituencies. Each community provides the opportunity for AST members to work together to educate one another and others on specific areas of transplantation, and also serves as a forum for transplant professionals to discuss common problems and issues that affect the community. The AST's communities of practice are an integral component of the society, providing networking and leadership opportunities for AST members, and guiding and supporting larger association-wide initiatives. For a full list of all AST communities of practice and for more information, click here.

    Save the date
    AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article

    Antibody Mediated Rejection in Liver Transplantation
    Endorsed by the American Society of Transplantation
    March 22-23, 2013, Dallas


    Transplantation barrier from unexpected variation in immune genes
    Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Human HLA genes — the genes that allow our immune system to tell the difference between our own cells and foreign invaders — are evolving much more rapidly than previously thought, according to an article online in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aimed at identifying potential donors for patients undergoing stem cell transplantation.

    Related articles:
  • Unexpected variation in immune genes poses difficulties for transplantation(Medical Xpress)
  • New approaches for optimizing transplant of sensitized patients (Organ Transplantation Research, subscription required)
  • The pathogenesis of acute allograft dysfunction in desensitized renal transplant recipients (Clinical Transplantation, subscription required)
  • More

    In animal model, heart muscle cell grafts suppress arrhythmias after heart attacks
    Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers have made a major advance in efforts to regenerate damaged hearts. Grafts of human cardiac muscle cells, grown from embryonic stem cells, coupled electrically and contracted synchronously with host muscle following transplantation in guinea pig hearts. The grafts also reduced the incidence of arrhythmias (irregular heart rhythms) in a guinea pig model of myocardial infarction (commonly known as a heart attack).

    Related articles:
  • Heart muscle cell grafts suppress arrhythmias after heart attacks in animal study (Science Codex)
  • Muscle cell grafts help damaged hearts keep beating (Laboratory Equipment)
  • More

    Donor/recipient size matching important in pediatric renal transplant
    Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Donor/recipient body surface area ratio should be taken into account when matching living donors with children who need a kidney transplant, investigators from Seattle Children's Hospital concluded. The team used data from the United Network of Organ Sharing's Standard Transplant Analysis Research files to show that a donor/recipient BSA ratio below 0.9 is associated with a 59 percent increased risk of graft loss by 10 years after kidney transplant in the pediatric population (younger than 18 years).

    Related articles:
  • More organ donors being turned away due to their weight (Diets in
  • Severely obese donors increase risk of death for pediatric liver transplant recipients (Doctors Lounge)
  • Obese donors OK or kids' liver transplants (MedPage Today)
  • More

    Iron overload increases post-transplant infection risk
    Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Kidney transplant recipients who have iron overload are at increased risk for bacterial infection compared with those who have normal iron levels, according to preliminary results of a Spanish study. The prospective study also revealed that ferritin levels above 500 ng/mL are associated with a higher risk of death within three years compared to lower ferritin levels. More

    HIV drug can prevent complications after stem-cell transplant
    OncologyNurseAdvisor    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A drug used in the treatment of HIV helped lower the risk of graft-versus-host disease in persons with blood cancer who underwent allogeneic hematopoietic stem-cell transplantation to rebuild bone marrow. More

    Assumptions about liver transplant waitlist mortality challenged    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The majority of liver patients who die on, or are removed from, the transplant waitlist have declined an offer of transplant, show the findings of an American study. Patients who died or were delisted received a median of six offers during the five-year study period, with 84 percent receiving at least one offer of a transplant. This is despite the fact that over half of them had received at least one offer of a high-quality liver. More

    Kidney transplant: Blood condition raises kids' risk
    Futurity    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    For children receiving kidney transplants, a potentially correctable blood condition is associated with a moderately increased risk of the graft's later failure. Findings suggest clinicians should weigh whether transplant is advisable when the condition is present, according to findings presented by researchers at the University of California, Davis, at the 24th International Congress of the Transplantation Society in Berlin. More

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