It's time to compensate kidney donors
AST
Several AST members were quoted in a recent New York Times article regarding compensating living donors. Tina Rosenberg investigates the Iranian system of paying organ donors, and looks at how this system could be applied in the United States.
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The independent living donor advocate
AST
Many in the transplantation community have questions about what the ILDA role entails and how to operationalize it. To clear up the confusion, I have invited Rebecca Hays, chair of the AST’s Live Donor Community of Practice (LDCOP) to blog about recent steps the AST has taken to address the role of the ILDA.
ASN plans early program on transplantation in cooperation with AST at Kidney Week 2015
AST
Join the American Society of Nephrology, in cooperation with the American Society of Transplantation, for the Kidney Transplantation Early Program on Nov. 3 - 4 prior to the start of the Kidney Week 2015 Annual Meeting (Nov. 3-8) in San Diego, California. Visit the ASN website for more details and to register. Registration rates increase on Sept. 16.
PRODUCT SHOWCASE
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You care about your transplant
patients. And so do we. That’s
why we’re introducing Astellas
Cares—a new program that
offers you customized tools,
educational resources, and
comprehensive support to help
your patients care for their
health. To register, visit
AstellasCares.com/Transplant
today.
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AST TIRN research grant request for proposals
AST
The AST Transplantation and Immunology Research Network (TIRN) research grants program supports fellows, junior faculty, and allied health professionals by funding innovative research in basic, clinical, and translational science. A limited number of grants will be awarded for research projects beginning July 1, 2016. The request for proposals is open now at www.TIRN.org/funding. Applications must be completed by 11:59 p.m. Pacific Standard Time on Sunday, November 1, 2015. For more information, visit www.TIRN.org or email TIRN@myAST.org.
Education and Clinical Tools for the Independent Living Donor Advocate: Webinar Aug. 19
AST
"Living Liver Donation A to Z: Understanding the Basics" is the next webinar in the Education and Clinical Tools for the Independent Living Donor Advocate (ILDA) webinar series, and takes place Wednesday, Aug. 19 at 1 p.m. EDT. The entire nine-webinar series developed by the AST Live Donor Community of Practice is free to AST members and their associates, just register with an AST member username and password at www.myAST.org/ILDA.
Non-members can purchase access to all nine webinars for just $200. Eligible non-members can join AST as a non-doctoral member and the webinar series is included in their $90 annual dues. Find out more at www.myAST.org/ILDA.
PRODUCT SHOWCASE
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The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
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UPCOMING EVENTS IN TRANSPLANTATION
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ASHI 41st Annual Meeting
ASHI
Sept. 28 - Oct. 2, 2015 | Savannah, GA
For more information: http://www.ashi-hla.org/events/annual-meeting/
2015 Banff/CST Joint Meeting
CST
Oct. 5-10, 2015 | Vancouver
For more information: http://www.cst-transplant.ca/meetings_asm.html
Society for Transplant Social Workers
STSW
Oct. 7-9, 2015 | Columbus, OH
For more information: https://www.stsw.org/conference/
ASN Kidney Week
ASN
Nov. 3-8, 2015 | San Diego, CA
For more information: https://www.asn-online.org/education/kidneyweek/
AASLD Liver Week
AASLD
Nov. 13-17, 2015 | San Francisco, CA
For more information: http://www.aasld.org/events-professional-development/liver-meeting
Save the date: CEOT 2016 – Cutting Edge of Transplantation
AST
Feb. 25-27, 2016 | Phoenix, AZ
For more information: http://2016.ceot.myast.org/
High HLA-DP Expression and Graft-versus-Host Disease
The New England Journal of Medicine
Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is higher when the recipient and donor are HLA-DPB1–mismatched, but the mechanisms leading to GVHD are unknown. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. We tested the hypothesis that the GVHD risk correlates with the rs9277534 allele linked to the mismatched HLA-DPB1 in the recipient.
Multicenter analysis of immune biomarkers and heart transplant outcomes: Results of the clinical trials in organ transplantation-05 study
American Journal of Transplantation
Identification of biomarkers that assess posttransplant risk is needed to improve long-term outcomes following heart transplantation. The Clinical Trials in Organ Transplantation (CTOT)-05 protocol was an observational, multicenter, cohort study of 200 heart transplant recipients followed for the first posttransplant year. The primary endpoint was a composite of death, graft loss/retransplantation, biopsy-proven acute rejection (BPAR), and cardiac allograft vasculopathy (CAV) as defined by intravascular ultrasound (IVUS).
PRODUCT SHOWCASE
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VTI’s disposable intraoperative Doppler probes are ready to verify technical results.
There’s no longer the need to perform sterilization that frequently causes irreversible damage to the traditional Doppler probes.
Advantages include fewer replacements of conventional Doppler probes damaged during sterilization, OR time saved, and a reduction in specialty procedures.
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Adoptive transfer of renal allograft tolerance in a large animal model
American Journal of Transplantation
Our recent studies in an inbred swine model demonstrated that both peripheral and intra-graft regulatory cells were required for the adoptive transfer of tolerance to a second, naïve donor-matched kidney. Here, we have asked whether both peripheral and intra-graft regulatory elements are required for adoptive transfer of tolerance when only a long-term tolerant (LTT) kidney is transplanted. Nine highly-inbred swine underwent a tolerance-inducing regimen to prepare LTT kidney grafts which were then transplanted to histocompatible recipients, with or without the peripheral cell populations required for adoptive transfer of tolerance to a naïve kidney.
Fatal rituximab-associated lung injury syndrome in a patient treated with rituximab for recurrence of post-transplant nephrotic syndrome
Pediatric Transplantation
Rituximab (anti-B CD20 ab.) in recently widely used in renal transplantation. Case history: A 10-yr-old patient with end-stage renal failure due to multidrug-resistant NS was transplanted with renal graft from deceased donor and presented immediate recurrence of NS. PF was started on day 3 and patient received MP pulses, however with no effect. Rituximab (4 × 375 mg/m2) was administered. Chest radiographs taken at that time were normal.
Two-year post-transplantation cytomegalovirus DNAemia in asymptomatic kidney transplant recipients: Incidence, risk factors, and outcome
Transplant Infectious Disease
The incidence and the impact of asymptomatic cytomegalovirus (CMV) DNAemia occurring after the first year post transplantation is unknown. In this retrospective cross-sectional study, we analyzed the incidence, risk factors, and impact of 2-year post-transplantation asymptomatic CMV DNAemia (2YCD) on graft function.
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