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A national survey of independent living donor advocates: The need for practice guidelines
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In 2000, representatives of the transplant community convened for a meeting on living donation in an effort to provide recommendations to promote the welfare of living donors. One key recommendation included in the consensus statement was that all transplant centers which have performed living donor surgeries have an independent living donor advocate (ILDA) "whose only focus is on the best interest of the donor." The aims of this study were to begin to understand the sociodemographic characteristics, selection and training, and clinical practices of ILDAs. More




PRESIDENT'S CORNER
Roslyn Mannon, MD

Conversations with the President


In her latest blog post, AST President, Dr. Roslyn Mannon writes about formulating a Clinical Research Community of Practice. Read the blog.

 SOCIETY NEWS


In case you missed it
AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Click here to see a video of Dr. Robert Gaston's presidential address. This address was presented at the 2012 American Transplant Congress in Boston.

Save the date for AST's first Cutting Edge of Transplantation (CEOT) meeting
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"B Cells from Bedside to Bench to Bedside: A Comprehensive Look at B Cells and Antibodies in Transplantation," will be held Feb. 14-16, 2013 in Phoenix. AST's Cutting Edge of Transplantation (CEOT) meeting is a multi-expert view of the most important clinical and research problems in transplantation. Integrated clinical transplant and basic science talks define best approaches to management and research questions. Not a clinical meeting, not a research meeting — simply the cutting edge of both.

Abstract submission opens soon. Clinical, basic and translational abstracts related to the meeting topic will be considered. Submit as many as you'd like!

Join clinical and basic science experts to address key management and research questions: What is the state of the field and the challenges to successfully transplanting sensitized patients? How does the immunobiology of B cells, plasma cells and antibody inform these challenges to clinical practice and suggest solutions? What are the best desensitization protocols and alternative therapies and their short- and long-term outcomes? Where are we in 'precision diagnosis' and continued monitoring of antibody-mediated rejection (AMR)?

Valentine's Day with AST: CEOT is about the joy of discovery. On Valentine's Day 2013, share that joy and discover the wild beauty of the desert with your loved one. Let the spirit of this ancient land breathe new energy into your lives together in a spectacular setting.


C1qScreen™: A New Research Tool for AMR Risk
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  • Detect Presence of Complement Fixing Antibodies
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For Research Use Only. Not for use in diagnostic procedures.


Poll: What is your preferred method for receiving your membership dues notice?
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AST would like your feedback. We are considering offering members a paperless option for membership dues renewal notices. Please take our poll here.

New addition to the Timely Topics in Transplantation Webcast Series
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Use your AST user login information to watch a free 30-minute webcast summarizing the Kidney Paired Donation (KPD) Consensus Conference held in March of this year. Click here and log in on the left hand side of the page (disregard the $25 price displayed on the right hand side of the page, this is for non-members). This webcast is part of the Timely Topics in Transplantation 2012 Webcast Series and will soon be posted on the AST website. View past free webcasts at www.a-s-t.org/T3.

The primary objective of this consensus conference was to identify and recommend best practices related to living kidney donor education and evaluation processes, communication processes, attenuation of participation barriers and donor follow-up care in the multi-center KPD setting. You will learn about alternative KPD allocation systems currently in use, challenges unique to KPD in terms of donor evaluation, geography, financing, histocompatibility and implementation and future directions for KPD allocation.


Athena Diagnostics

Genetic testing can be a cost-effective way to increase the number of living related donor transplants. Mutational analysis may help direct long-term treatment plans, including pre-operative screening of potential kidney transplant recipients and living related donors.
more


The ESOT-AST Joint Meeting: Cutting edge science
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"Transformational Therapies and Diagnostics in Transplantation," will be held on Oct. 12-14 at Palais de la Méditerranée in Nice, France. ESOT and AST have partnered once again to present the best transplantation science. The international faculty will critically analyze important topics such as: The results of recent clinical trials using costimulation blockade, new challenges in the diagnosis and treatment of antibody mediated rejection, pharmacogenetic testing in patient management, new immunosuppressive agents in the pipeline, new interventions for delayed graft function and graft fibrosis and current immunosuppressive therapies and identify unfulfilled needs and potential new interventions.

Register by Sept. 21 to take advantage of the early registration discounted rates. Register online at www.a-s-t.org/events/astesot-joint-meeting. View the program and travel information here.











 TRANSPLANT NEWS


Molecular and protein markers discovered for liver transplant failure from hepatitis C
Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage. Such early detection of susceptibility to hepatitis C virus-induced liver injury could lead to more personalized monitoring and treatment options after a transplant.

Related articles:
Molecular and protein markers predict liver transplant failure in hepatitis C patients (University of Washington)
Biomarkers predict liver transplant failure (Genetic Engineering & Biomedical News)
More

Medical debate: Should autism block a man from getting a heart transplant?
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Twenty-three-year-old Paul Corby has a bad heart and a flawed mind. The question before doctors now is whether his mental problems — he has a form of autism — are severe enough to make him a bad candidate for a heart transplant. Doctors at the Hospital of the University of Pennsylvania have said they are, according to Paul's mother, Karen. She disagrees and is using an online petition and the support of a network of autism advocates to make her case.

Related articles:
Mom seeks heart transplant for autistic son (R&D Magazine)
Autism as a death sentence Long Beach Press-Telegram (Long Beach Press-Telegram)
More

Donor information for living donor liver transplantation: Where can comprehensive information be found?
Liver Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Recently published data show that a large number of candidates for living donor liver transplantation (LDLT) actively look for additional information on the Internet because today it represents the main source of information for many of them. However, little is known about the quality of the information on LDLT available on the Internet. Analysis demonstrated several significant shortcomings in the quality of the information provided to potential donors for LDLT according to the EQIP instrument. Researchers conclude that there is an urgent need to produce a website compliant with international standards for the quality of donor information. More

CMV prophylaxis better for preventing graft loss
Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Prevention of cytomegalovirus disease can be achieved either with prophylactic or preemptive use of antiviral agents after kidney transplantation, but prophylaxis is associated with a lower rate of graft loss or death, according to findings presented at the 24th International Congress of The Transplantation Society. The findings emerged from an ongoing study in which 146 renal transplant recipients were randomized to receive valganciclovir prophylaxis and 150 were randomized to receive preemptive therapy with the drug. More

B cell survival holds key to chronic graft vs. host disease
Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime and ultimately affect their long-term survival. A paper published by a team from the University of North Carolina's Lineberger Comprehensive Cancer Center shows in the laboratory that B cells from patients with chronic GVHD are much more active than cells from patients without the disease. The team also outlines the cell signaling pathways that contribute to this increased activity — identifying a promising target for developing new therapies for the diseases. More

Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation
Current Opinion in Organ Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As critical determinants of the local and systemic immune response to solid organ allografts, macrophage subpopulations represent attractive therapeutic targets. Rapid progress is being made in the implementation of novel macrophage-targeted therapies, particularly in the use of ex-vivo-generated M regs as a cell-based medicinal product. More

Southampton scientists to investigate ways to prevent life-threatening complications in transplant patients
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists from the University of Southampton have received a grant from the blood cancer charity Leukaemia & Lymphoma Research to explore ways of preventing life-threatening side effects in patients receiving bone marrow transplants. The team, led by Aymen Al-Shamkhani a Professor of Immunology, has received £270,000 (US $427, 000) for the three-year project to improve transplants, which often offer a last chance of a cure for patients with many different types of blood cancer. More

Aggressive lung donor management increases graft procurement without increasing renal graft loss after transplantation
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
To determine the impact of an aggressive protocol on the rate of lung grafts available for transplant, researchers analyzed the impact of aggressive management on kidney graft survival after kidney transplantation. Aggressive management strategy in potential lung donors, which includes ventilator recruitment maneuvers, PEEP ≥8 cm H2O, the use of HRT and restrictive fluid balance increases the rate of lung grafts available for transplantation without adverse effect on kidney graft survival. More
 



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