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1-year experience with intravenous treprostinil for pulmonary arterial hypertension
The Journal of Heart and Lung Transplantation (login required)
Intravenous (IV) epoprostenol has been the mainstay of therapy in advanced pulmonary arterial hypertension (PAH). Continuous IV treprostinil has several potential advantages over IV epoprostenol; however, there has been a lack of published long-term efficacy and safety data on IV treprostinil in PAH.
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SOCIETY NEWS


Donor Management Research Consensus Conference: Registration now open!
AST
When: Monday, Sept. 16,1-5:30 p.m.; and Tuesday, Sept. 17, 8 a.m.-3:30 p.m.
Where: Sheraton Pentagon City Hotel, 900 South Orme Street, Arlington, VA
Register here!
This meeting allows members of the DTCP to come together to identify challenges that the community has identified related to donor management research. Participants will work toward consensus on issues related to donors, identify issues related to informed consent in the recipient, recognize and address informed consent issues regarding the effect of research on organs that are not receiving the direct impact of the research protocol, and promote donor management research and human subjects processes that are satisfactory to donor hospitals, donation community, transplant community and the public.

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PRODUCT SHOWCASE
  University of Utah - Multi-Organ Transplant Surgeon
The University Of Utah Department Of Surgery is seeking applications for a faculty member to join the multi-organ transplant team at the assistant professor level. This is an opportunity to join an expanding program and a cohesive group of transplant surgeons focused on excellence. The candidate should be board certified in general surgery and have completed an ASTS approved transplantation surgery fellowship. Apply here
 


Tickets are on sale for the Power2Save concert featuring The Band Perry!
Upgrade your concert experience while giving to Power2Save. This limited quantity, special ticket package is $250 and is only available on the P2S website! This package includes:
  • Premium seating (choice of floor seat or padded premium seat in elevated section)
  • Access to an exclusive pre-concert reception with food and beverages
  • 1 signed copy of The Band Perry's new CD Pioneer
  • A contribution of $140 toward the Power2Save initiative
Buy your ticket now! Can't attend the concert? Make a donation to Power2Save. All donations go toward the Power2Save mission, which is dedicated to increasing public awareness of the importance of donating organs, advocating for patient health and funding transplant research through the Transplant Research Institute.

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Wanted: Your nominations for the 2014 AST Board
AST
Dr. Roslyn Mannon, chair of the AST Governance Committee, invites AST members to submit nominations for qualified individuals to serve on the AST Board of Directors. Open positions include eresident-elect (one year term), treasurer (two year term), and three councilors-at-large (three year terms each). Read the official announcement here.
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The University of Vermont/Fletcher Allen Health Care is seeking applications for a senior faculty member to join the Division of Nephrology. The candidate should be UNOS certified in kidney and pancreas transplants, experienced in educating nephrology fellows, growing transplant programs, and providing administrative leadership. Apply Here
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TRANSPLANT NEWS


Test performance characteristics of quantitative nucleic acid testing for polyomaviruses in kidney and kidney-pancreas transplant recipients
Clinical Transplantation (login required)
Screening for polyoma BK virus (BK) using nucleic testing (NAT) is recommended for kidney and kidney-pancreas transplant recipients, but the performance characteristics of quantitative BK NAT at different thresholds of plasma BK viral loads are unclear. We aim to evaluate the diagnostic accuracy of quantitative BK NAT as an add-on test to qualitative polyoma NAT for the diagnosis of BK virus-associated nephropathy (BKVAN) in kidney and kidney transplant recipients.
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Experience of extracorporeal membrane oxygenation as a bridge to lung transplantation in France
The Journal of Heart and Lung Transplantation (login required)
Extracorporeal membrane oxygenation (ECMO) is increasingly used as a bridge to lung transplantation (LTx). However, data concerning this approach remain limited. The study confirms that the use of ECMO as a bridge to LTx in France could provide a medium-term survival benefit for LTx recipients with critical conditions. Survival differed by underlying respiratory disease. Larger studies are needed to further define the optimal use of ECMO.
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It is more than just size: Obesity and transplantation
Liver Transplantation (login required)
The obesity pandemic is an inescapable problem in healthcare. A recent survey found nearly 80 million Americans, or 36 percent of the population older than 20 years, to be obese. Those caring for persons with end-stage liver disease have seen a 5.4 percent increase in the number of living transplant candidates with a body mass index greater than 30 kg/m2 in the United States.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Current role of human leukocyte antigen matching in kidney transplantation (NCBI)
Social media and organ donor registration: The Facebook effect (American Journal of Transplantation)
Using implantation biopsies as a surrogate to evaluate selection criteria for living kidney donors (Transplantation)
Mechanical circulatory support and heart transplantation: Donor and recipient factors influencing graft survival. (NCBI)
Preformed class II donor-specific antibodies are associated with an increased risk of early rejection after liver transplantation (NCBI)

Don't be left behind. Click here to see what else you missed.


It's up to you: A multi-message, phased driver facility campaign to increase organ donation registration rates in Illinois
Clinical Transplantation (login required)
The present project applied successful strategies employed in previous driver facility campaigns occurring during the inception of a registry to examine whether these approaches are effective in growing a mature registry, a registry where the majority of individuals have had the opportunity to register as an organ donor.
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Review: Size matching in lung transplantation
The Journal of Heart and Lung Transplantation (login required)
The evidence base for size matching between donors and recipients in lung transplantation has not recently been reviewed in a comprehensive manner. The aim in this study was to assimilate published studies that have addressed size matching of donors to recipients and to establish a pragmatic understanding of the range of lung sizes that may be used for lung transplantation. A comprehensive literature search was performed using Medline and PubMed up to and including September 2012, to identify scientific articles that relate to size matching between donors and lung transplant recipients. Seventy-two articles were identified, of which 21 had addressed the question of the impact of size mismatching on outcomes in lung transplantation.
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The time to address the gorillas in the room is overdue
Liver Transplantation (login required)
The two gorillas in the room are: 1)liver allocation in the United States is not equal by any significant metric (wait-time, model for end-stage liver disease score at transplantation, regional review board behavior), and 2) liver allograft utilization, as referenced by an increasing gap between consented liver deceased-donors and transplanted deceased-donor allografts or a decreasing donor risk index at transplantation, is declining.
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Cytomegalovirus prophylaxis in pediatric kidney transplantation: The Dutch experience
Pediatric Transplantation (login required)
Many children receiving a kidney transplant are seronegative for cytomegalovirus (CMV) and therefore, highly susceptible to a primary CMV infection. This study aims at evaluating incidence, time of occurrence, and severity of CMV infection in the first year post-transplantation in relation to different types of CMV prophylaxis. Transplantations in three centers in the Netherlands between 1999 and 2010 were included.
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The safety and efficacy of acute graft-versus-host disease prophylaxis with a higher target blood concentration of cyclosporine around 500 ng/mL
Clinical Transplantation
Cyclosporine (CsA) is the most widely used immunosuppressive agent for the prevention of acute graft-versus-host disease (GVHD). In a previous report, the incidence of acute GVHD was decreased by increasing the target blood concentration of CsA during a continuous infusion from 300 to 500 ng/mL without excessive toxicities. To confirm these results, we retrospectively analyzed 69 patients who received a continuous infusion of CsA at a higher target CsA level between 450 and 550 ng/mL (CsA500 group) and compared the clinical outcome with 29 patients who received CsA with a lower target concentration between 250 and 350 ng/mL (CsA300 group).
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Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes
Xenotransplantation (login required)
Humanized chimeric mice have been generated by transplanting h-hepatocytes into the livers of the diseased-liver transgenic mouse model with immunodeficient background. These mice with livers mostly replaced by human (h) hepatocytes have been proved to be useful for research on drug metabolism and toxicity and on intrahepatic pathogens such as hepatitis. However, their small body size prohibited collecting sufficient biological samples and made surgical manipulation difficult, which motivated us to produce humanized larger animal(s) bearing h-hepatocytes.
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