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Paraoxonase 1 and oxidative stress in pediatric non-alcoholic steatohepatitis
Liver International (login required)
Non-alcoholic steatohepatitis (NASH) in children is a significant public health concern. Oxidative stress is an important component in the pathophysiology of NASH. Several enzymatic antioxidant mechanisms protect the liver from oxidative injury. Examination of the expression of these enzymes in NASH livers may provide insight on the roles for these antioxidant mechanisms in the pathophysiology of NASH.
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AST website maintenance
AST
As part of our regular system maintenance and upgrade processes, beginning Monday, Sept. 2, at approximately 5 p.m. EST, the website login and online services at www.myAST.org will be unavailable. We anticipate the website to return to its functional state by noon EST on Tuesday, Sept. 3, if not sooner.
Save the date for your AST grant applications!
AST
The submission website for the 2014 AST Grants program will open for submissions on Monday, Sept. 9. The deadline for complete application submission is Monday, Dec. 16. Learn more about available grants and application criteria here.
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PRODUCT SHOWCASE
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The University Of Utah Department Of Surgery is seeking applications for a faculty member to join the multi-organ transplant team at the assistant professor level. This is an opportunity to join an expanding program and a cohesive group of transplant surgeons focused on excellence. The candidate should be board certified in general surgery and have completed an ASTS approved transplantation surgery fellowship. Apply here
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Wanted: Your nominations for the 2014 AST Board
AST
Dr. Roslyn Mannon, chair of the AST Governance Committee, invites AST members to submit nominations for qualified individuals to serve on the AST Board of Directors. Open positions include president-elect (one year term), treasurer (two year term), and three councilors-at-large (three year terms each). Read the official announcement here.
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Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
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The University of Vermont/Fletcher Allen Health Care is seeking applications for a senior faculty member to join the Division of Nephrology. The candidate should be UNOS certified in kidney and pancreas transplants, experienced in educating nephrology fellows, growing transplant programs, and providing administrative leadership.
Apply Here
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The FlowSight offers high performance in a small package. Its innovative design increases signal and minimizes noise to provide unmatched fluorescence sensitivity. Twelve standard detection channels simultaneously produce brightfield, darkfield and up to ten channels of fluorescence imagery of every cell. More info
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Extrarenal factors influencing resistance Index in stable kidney transplant Recipients
Transplantation (login required)
Increased intrarenal resistance index (RI) has been associated with decreased long-term allograft and patient survival in kidney transplant recipients. Taking into account the potential role of endothelial dysfunction, systemic inflammation, arteriosclerotic lesions and left ventricle remodeling, researchers performed a cross-sectional study that aimed to evaluate extrarenal factors that may have influence on kidney graft RI in a large cohort of stable kidney transplant recipients.
Implantable, Artificial Kidney: Shuvo Roy, Ph.D.
Renal & Urology News
Shuvo Roy, Ph.D., a bioengineering professor at the University of California, San Francisco, is developing an artificial kidney that could change the lives of millions of people around the world.
Report: Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection
Transplantation
Urinary tract infection (UTI) is a frequent, serious complication in kidney allograft recipients. In a recent study, researchers reviewed the records of 1166 kidney allograft recipients who received their allografts at our institution between January 2005 and December 2010 and determined the incidence of UTI during the first 3 months after transplantation (early UTI).
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Effect of ciprofloxacin with sulfamethoxazole-trimethoprim prophylaxis on the incidence of urinary tract infections after kidney transplantation
Transplantation (login required)
Urinary tract infections (UTIs) are common after kidney transplantation, with limited data to guide antibiotic prophylaxis. Retrospective single-center study comparing sulfamethoxazole-trimethoprim 800/160 mg (SMZ/TMP) daily for 30 days followed by Monday, Wednesday, Friday for an additional 5 months (Group 1) versus SMZ/TMP Monday, Wednesday, Friday for 6 months plus ciprofloxacin 250 mg twice daily for 30 days (Group 2) on UTI incidence after kidney transplantation.
Lung transplantation after lung volume reduction surgery
Transplantation (login required)
Lung volume reduction surgery (LVRS) as a bridge to lung transplantation was first advocated in 1995 and published studies have supported the concept but with limited data. The risk-benefit tradeoffs of the combined procedure have not been thoroughly examined, although substantial information regarding LVRS has emerged.
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Transplant IV Biologics and Oral Immunosuppressives specializing in Desensitization and AMR Treatment and Prevention. MORE
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Kidney transplant recipient with BK virus infection: Practice points for clinicians
Medscape (login required)
 This interview with Dr. Simon Goral and Dr. Sundaram Hariharan, is part of program that includes a discussion of the off-label use of leflunomide, cidofovir, intravenous immune globulin (IVIG), and fluoroquinolone antibiotics for the treatment of polyomavirus BK (BKV) infection.
China: Organ transplant program will phase out executed inmates
Reuters via The New York Times
China will start phasing out its long-held practice of using the organs of executed prisoners for transplant operations in November, a senior official said recently, as it pushes to mandate the use of organs from ethical sources in hospitals.
The use of transient elastography and non-invasive serum markers of fibrosis in pediatric liver transplant recipients
Pediatric Transplantation (login required)
The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver-transplanted children (60M, 8.9 [0.5–18.5] yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann–Whitney U-test as appropriate. TE correlated best with histological degree of fibrosis.
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