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Predictors and consequences of fatigue in prevalent kidney transplant tecipients
Transplantation (login required)
Fatigue has been underinvestigated in stable kidney transplant recipients (KTRs). The objectives of this study were to investigate the nature, severity, prevalence and clinical awareness of fatigue in medically stable KTRs, examine the impact of fatigue on quality of life (QoL), and explore the underlying causes of posttransplantation fatigue.
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SOCIETY NEWS


Attend the FDA's Clinical Investigator Training Course
FDA
The Fifth Annual Clinical Investigator's course, co-sponsored by the Food and Drug Administration's office of Medical Policy and the Duke School of Medicine, is now open for registration. This three-day course is offered to new investigators, and will be held on Nov. 12-14 at the Holiday Inn, College Park, Md. Register for the course and view a draft agenda here. To make reservations at the Holiday Inn, College Park, call 301-345-6700 or email reservations@hicollegepark.com.
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Submit your application for research grants starting Monday!
AST
The submission website for the 2014 AST Grants program will open for submissions on Monday, Sept. 9. The deadline for complete application submission is Monday, Dec. 16. Learn more about available grants and application criteria here.
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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


Visit the new COP websites today!
AST
The AST launched new Community of Practice (COP) websites earlier this summer. These websites provide community members an opportunity to interact and collaborate with each other through features like a discussion board, shared document section and calendar of events. Click here to check out your COP's website, and log in with your AST website username and password. Contact the AST staff with questions at info@myAST.org.
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The Timely Topics in Transplantation (T3) Webinar Series is back and It's LIVE!
AST
The AST's popular webinar series is back for 2013-2014, with webinars held live every month from October through April of 2014. Topics include: A review of AST's ID guidelines, wrapups of the Banff and IPITA meetings, improving adherence in challenging patients, kidney allocation update, UNOS living donor care policies, Hepatitis C therapy and pre-transplant HLA testing. Click here for webinar details as they are announced. All webinars are held on a Tuesday from 2-3 p.m. ET.
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Wanted: Your nominations for the 2014 AST Board
AST
Dr. Roslyn Mannon, chair of the AST Governance Committee, invites AST members to submit nominations for qualified individuals to serve on the AST Board of Directors. Open positions include president-elect (one year term), treasurer (two year term), and three councilors-at-large (three year terms each). Read the official announcement here.
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TRANSPLANT NEWS


Safe use of highly steatotic livers by utilizing a donor/recipient clinical algorithm
Clinical Transplantation (login required)
The aim of this study was to assess the long-term safety and clinical outcomes associated with the utilization of highly steatotic donor livers utilizing a specific donor/recipient matching algorithm. This was a prospective, observational, single-center, 10-year follow-up study
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Safety and efficacy of RNAi therapy for transthyretin amyloidosis
The New England Journal of Medicine (login required)
Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by RNA interference (RNAi) could reduce the production of transthyretin. In this study, researchers identified a potent antitransthyretin small interfering RNA, which was encapsulated in two distinct first- and second-generation formulations of lipid nanoparticles, generating ALN-TTR01 and ALN-TTR02, respectively.
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Coordinating unspecified living kidney donation and transplantation across the blood-type barrier in kidney exchange
Transplantation (login required)
This article studies multicenter coordination of unspecified living kidney donation and transplantation across the blood-type barrier in kidney exchange. Important questions are whether such coordination should use domino paired donation or nonsimultaneous extended altruistic donor chains, what the length of the segments in such chains should be, when they should be terminated, and how much time should be allowed between matching rounds. Furthermore, it is controversial whether the different modalities should be coordinated centrally or locally and independently.
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Lower socioeconomic status is associated with worse outcomes after both listing and transplanting children with heart failure
Pediatric Transplantation (login required)
The relationship between SES and outcomes surrounding pediatric cardiac transplantation is complex and influenced by recipient race. Broad-based studies of SES have not been performed. A retrospective review of all 5,125 primary pediatric heart transplants performed in the United States between 2000 and 2011.
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The wave of the future: Noninvasive tests for kidney transplants
By Darla Ferrara
Rejection is always a consideration when discussing the success rate of solid organ transplants. Currently, the only way to tell the difference between rejection and other types of post-transplant kidney injury is through biopsy. But a recent study by the National Institute of Allergy and Infectious Diseases offers a noninvasive way to provide early indication of rejection. The study suggests that low levels of the CXCL9 protein are an indicator of how likely rejection is after transplant surgery. What does this mean to the transplant community?
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Implantable, Artificial Kidney: Shuvo Roy, Ph.D. (Renal & Urology News)
Report: Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection (Transplantation)
Kidney transplant recipient with BK virus infection: Practice points for clinicians (Medscape)
Paraoxonase 1 and oxidative stress in pediatric non-alcoholic steatohepatitis (Liver International)
Extrarenal factors influencing resistance Index in stable kidney transplant Recipients (Transplantation)

Don't be left behind. Click here to see what else you missed.


The HALOS-ND model: A step in the journey of predicting hospital length of stay after liver transplantation
Clinical Transplantation (login required)
Hospital length of stay (LOS) after liver transplantation has been determined to correlate with liver disease severity, posttransplant survival rates, and transplant-associated costs. A patient's model for end-stage liver disease score and an organ's donor risk index have both been found to be significant predictors of LOS, but these two factors alone are insufficient to form an accurate prediction.
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Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation
Transplantation (login required)
Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regulation results critical in several biological processes.
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The use of transient elastography and non-invasive serum markers of fibrosis in pediatric liver transplant recipients
Pediatric Transplantation (login required)
The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver-transplanted children (60M, 8.9 [0.5–18.5] yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann–Whitney U-test as appropriate. TE correlated best with histological degree of fibrosis.
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