This message contains images. If you don't see images, click here to view.
Click here to advertise in this news brief.


Advertisement


 Mobile version  RSS  Subscribe  Unsubscribe  Archive  Media Kit

Home   About AST   Education   Meetings & Events   Public Policy   Contact Us   Sep. 20, 2013


Advertisement

Advertisement
 

Advertisement


Understanding the OPTN/UNOS PHS Guideline
AST
Effective Oct. 1, a new policy (3.1.14) created to define the PHS Guideline will allow members to use either the 1994 or the 2013 version. It will also require members to specify which version they are using in the donor highlights section of DonorNet. Click here for more information, or see a comparison of the guidelines.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article


Advertisement


SOCIETY NEWS


Get ready for Power2Save
AST
Join in the AST's efforts to be the clear and consistent voice for the transplant community by being part of Power2Save. Attend the concert on Nov. 1, make a donation, or get involved with transplant advocacy.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


Free webinars for AST members
AST
AST's Timely Topics in Transplantation webinar series is available free to members 24/7 online Webinars include "DSA: New Concerns and New Therapies," "New Strategies in Hepatitis Management," and "Meeting the Challenges of Resistance." The AST's Business of Transplantation live webinar series has concluded, but all eight webinars are available in archive format.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article


PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


TRANSPLANT NEWS


Trial: Improving outcomes of renal transplant recipients with behavioral adherence contracts
American Journal of Transplantation (login required)
The objective of this randomized controlled trial was to assess the effects of a 1-year behavioral contract intervention on immunosuppressant therapy (IST) adherence and healthcare utilizations and costs among adult renal transplant recipients (RTRs). The sample included adult RTRs who were at least 1 year posttransplant, taking tacrolimus or cyclosporine and served by a specialty pharmacy.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


Managing renal transplant ischemia reperfusion injury: novel therapies in the pipeline
Clinical Transplantation (login required)
Ischemia reperfusion injury (IRI) is an early, non-specific inflammatory response that follows perfusion of warm blood into a cold asanguinous organ following transplantation. The occurrence of IRI may have a pivotal impact on acute and long-term renal allograft function. Initially, IRI contributes to delayed graft function (DGF), a term typically defined as the need for dialysis within one week after renal transplantation. DGF frequently leads to prolonged hospital stay, increased healthcare costs and potentially worse prognosis.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE




Alcohol and substance abuse in solid-organ transplant recipients
Transplantation (login required)
This review focuses on alcohol and substance abuse in the context of solid-organ transplantation. Alcohol and substance abuse are common and may lead to a need for solid-organ transplantation and may also contribute to significant physical and psychologic problems that impact upon the recipient. Damaging levels of alcohol intake can occur in the absence of dependence. Alcohol or substance abuse after transplantation is associated with poor medication compliance and this may increase risk of graft loss.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


A prospective controlled study of kidney donors: Baseline and 6-month follow-up
American Journal of Kidney Diseases
Most previous studies of living kidney donors have been retrospective and have lacked suitable healthy controls. Needed are prospective controlled studies to better understand the effects of a mild reduction in kidney function from kidney donation in otherwise healthy individuals.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction
Transplantation (login required)
Positive crossmatch (CM) in liver transplantation (LT) is associated with worse outcomes. Role of induction immunosuppression in this setting remains to be studied. In this study, 1,000 consecutive LT patients receiving rabbit antithymocyte globulin+/-rituximab induction were studied. Pretransplantation sera of 55 CM-positive (CM+) patients were tested for C1q-fixing donor-specific antibodies (DSA). Diagnosis of antibody-mediated rejection required presence of diffuse vascular C4d expression on liver biopsies.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


Featured Advertisers


Advertisement


Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
Advertisement
University of Vermont Transplant Nephrologist

The University of Vermont/Fletcher Allen Health Care is seeking applications for a senior faculty member to join the Division of Nephrology. The candidate should be UNOS certified in kidney and pancreas transplants, experienced in educating nephrology fellows, growing transplant programs, and providing administrative leadership. Apply Here
Amnis
The FlowSight offers high performance in a small package. Its innovative design increases signal and minimizes noise to provide unmatched fluorescence sensitivity. Twelve standard detection channels simultaneously produce brightfield, darkfield and up to ten channels of fluorescence imagery of every cell. More info


The use of transient elastography and non-invasive serum markers of fibrosis in pediatric liver transplant recipients
Pediatric Transplantation (login required)
The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT and ELF score were performed in 117 liver-transplanted children and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann–Whitney U-test as appropriate.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Cancer risk after ABO-incompatible living-donor kidney transplantation (Transplantation)
Preformed class II donor-specific antibodies are associated with an increased risk of early rejection after liver transplantation (Liver Transplantation)
Granulocyte colony-stimulating factor therapy: Reduced incidence of acute rejection episodes, allograft vasculopathy in heart transplant recipients (Transplantation Proceedings)
Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival (Liver International)
Will China's organ transplant reforms really work? (The Atlantic)

Don't be left behind. Click here to see what else you missed.


The safety and efficacy of acute graft-versus-host disease prophylaxis with a higher target blood concentration of cyclosporine around 500 ng/mL
Clinical Transplantation (login required)
Cyclosporine is the most widely used immunosuppressive agent for the prevention of acute graft-versus-host disease. In a previous report, the incidence of acute GVHD was decreased by increasing the target blood concentration of CsA during a continuous infusion from 300 to 500 ng/mL without excessive toxicities. To confirm these results, researchres retrospectively analyzed 69 patients who received a continuous infusion of CsA at a higher target CsA level between 450 and 550 ng/mL (CsA500 group) and compared the clinical outcome with 29 patients who received CsA with a lower target concentration between 250 and 350 ng/mL (CsA300 group).
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE


Renal Ischemia-Reperfusion Injury Amplifies the Humoral Immune Response
Journal of the American Society of Nephrology
Renal transplant recipients who experience delayed graft function have increased risks of rejection and long-term graft failure. Ischemic damage is the most common cause of delayed graft function, and although it is known that tissue inflammation accompanies renal ischemia, it is unknown whether renal ischemia affects the production of antibodies by B lymphocytes, which may lead to chronic humoral rejection and allograft failure.
Share this article:   Share on FacebookTwitterShare on LinkedinE-mail article
READ MORE
 



AST eNews

Colby Horton, Vice President of Publishing, 469.420.2601
Download media kit

Courtney Hodges, Content Editor, 972.402.2604   
Contribute news


This edition of the AST eNews was sent to ##Email##. To unsubscribe, click here.

Recent issues
Sept. 13, 2013
Sept. 6, 2013
Aug. 30, 2013
Aug. 23, 2013






7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063