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AST Awards Program: Nominate your colleagues
The AST is soliciting nominations for the 2015 AST Achievement Awards, and the deadline for submissions is Monday, Nov. 17, 2014. AST sponsors a variety of achievement awards according to faculty rank in recognition of our members' achievements and contributions to the field of transplantation. AST members are encouraged to nominate deserving candidates for consideration. For complete information on awards eligibility criteria, application requirements, the review process, and to submit a nomination, please visit the awards section of the AST website.
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In case you missed it...
Be sure to check out the latest president's blog posting on the AST website. This week's topic is "The Potential Risks of Living Donation" by Peter Reese and John Gill. Click here to read the blog. Your comments are also welcome!
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Register for Webinars: Kidney Allocation System Preparedness, Changes in Healthcare, Vaccine Updates
Kidney Allocation System Changes: Strategies to Improve Recipient Readiness and Reduce Disparities: Tuesday, Nov. 4, 2-3 p.m. EST. Register today at - free for AST members.

Changes in the Health Care Environment and Transplantation: Wednesday, Nov. 12, 2014, 2-3 p.m. EST. Register today at - free for AST members. Understand changes in the healthcare environment and the effect of the ACA on transplantation.

Vaccine Updates in SOT: What's New, What's Standard of Care?: Tuesday, Nov. 18, 2-3 p.m. EST. Register today at - free for AST members.

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Only 1 week left to submit your abstract for CEOT on any transplantation or immunology topic
The Cutting Edge of Transplantation
Immunity and Inflammation: Engineering Cell, Gene, and Drug Therapies

Feb. 5-7, 2015
Sheraton Wild Horse Pass – Chandler, Arizona

The AST is accepting abstracts for the Cutting Edge of Transplantation meeting until Oct. 31. Don’t miss out on the opportunity to share your research with experts in transplantation. Submit your basic, clinical or translational abstract on any transplantation or immunology topic by Oct. 31. The AST will award a limited number of Young Innovator Award travel grants to the highest scoring abstracts submitted by emerging professionals in transplantation.

Click here to register for CEOT 2015 and take advantage of early registration discounted rates! Or, learn more about this engaging meeting and view the preliminary program here.

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Effect of dialysis initiation for preemptively listed candidates in the revised kidney allocation policy
American Journal of Transplantation
The new allocation policy for deceased donor kidneys in the United States is expected to begin in late 2014. As part of this policy, prioritization to the highest quality deceased donor kidneys is dependent on candidate's estimated posttransplant survival (EPTS) score. In particular, candidates with low (≤ 20 percent) EPTS (indicating better estimated survival) will have greater access to donor offers. This study evaluated the effect of dialysis initiation on preemptively listed candidates' EPTS score.
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A systematic review of the use of rituximab for desensitization in renal transplantation
Rituximab is a B lymphocyte–depleting agent used to treat lymphoma and autoimmune diseases. Recently, it has been used for desensitization therapy in ABO-incompatible and highly sensitized recipients undergoing renal transplantation. A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Four databases and three trial registries were searched for studies comparing rituximab with non-rituximab desensitization protocols. A lack of randomized evidence precluded meta-analysis, and thus a narrative review was conducted.
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Graft-versus-host disease after simultaneous pancreas-kidney transplantation: a case report and review of the literature
American Journal of Transplantation
Graft-versus-host disease after solid organ transplantation is rare and usually fatal. We present, to our knowledge, the second successfully treated case in a simultaneous pancreas–kidney transplant recipient.
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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE

A cross-sectional study examining the functional independence of elderly individuals with a functioning kidney transplant
Cross-sectional studies of patients dependent on dialysis show that they have a high need for help with routine daily activities. In many cases, individuals who undergo kidney transplantation have previously been treated with dialysis for a significant period of time, thus many of the characteristics may be similar. The purpose of this study was to estimate the rate of functional disability in a cross-sectional population of older patients with a functioning kidney transplant.
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Medication misuse, non-adherence, and clinical outcomes among liver transplant recipients
Liver Transplantation
Medication non-adherence after liver transplantation (LT) is associated with adverse clinical outcomes such as graft rejection and graft loss. Few studies have examined non-adherence and the impact on clinical outcomes in LT. Study objectives were to evaluate: 1) medication understanding (using treatment knowledge and demonstrated regimen use scores) and medication (non)-adherence of entire regimens among LT recipients, and 2) examine associations of these exposures with clinical outcomes. We conducted a two-site study of 105 recipients between 2011 and 2012 at two transplant centers in Chicago and Atlanta.
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Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards
Clinical Transplantation
Infections with cytomegalovirus (CMV) and Epstein Barr Virus (EBV) remain important in solid organ transplantation. Quantitative viral nucleic acid testing is a major advance to patient management. These assays are limited by a lack of standardization, resulting in viral load measurements that differ among clinical laboratories. The variability in viral load measurements makes interpretation of multicenter clinical trials data difficult. This study compares the current practices in CMV and EBV viral load testing at four large transplant centers participating in multicenter Clinical Trials in Organ Transplantation (CTOT/CTOTC).
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Family strain and its relation to psychosocial dysfunction in children and adolescents after liver transplantation
Pediatric Transplantation
Parental functioning is essential to children's development. Therefore, this cross-sectional single-center study examined the prevalence of family strain in 181 parents and its associations to psychosocial functioning in their children after LT. Median age at LT was one yr. Mean time elapsed since LT was 5.8 yr. The IFS, and the SDQ were applied to parents.
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The World Transplant Games: An incentive to improve physical fitness and habitual activity in pediatric solid organ transplant recipients
Pediatric Transplantation
This prospective, interventional study examined the impact of training for the WTG on levels of health-related physical fitness and habitual activity in a cohort of pediatric SOT recipients. Physical fitness (FitnessGram®) and habitual activity (HAES) measures were performed on participants (n = 19) in the WTG and compared to non-participant controls (n = 14) prior to and following the WTG. Pre-WTG exercise training was provided to participants.
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Missed last week's issue? See which articles your colleagues read most.

    OPTN/UNOS guidance regarding Ebola (AST)
Pre-transplant donor HLA-specific antibodies: Characteristics causing detrimental effects on survival after lung transplantation (The Journal of Heart and Lung Transplantation)
Evaluation of solid organ transplant candidates for coronary artery disease (American Journal of Transplantation)
Drive-line infections and sepsis in patients receiving the HVAD system as a left ventricular assist device (The Journal of Heart and Lung Transplantation)

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Colby Horton, Vice President of Publishing, 469.420.2601
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Julie Bernhard, Executive Editor, 469.420.2647  
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