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AST
The AST launched the Transplantation and Immunology Research Network (TIRN) to expand the scope, reach, funding, and effectiveness of the AST’s research program. Here, Dan Salomon and Anil Chandraker introduce TIRN’s newest feature: the researcher registry.
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AST
This announcement solicits applications for Social and Behavioral Interventions to Increase Organ Donation, a grant program administered by the Division of Transplantation (DoT), Healthcare Systems Bureau (HSB), Health Resources and Services Administration (HRSA), U.S. Department of Health and Human Services (HHS). The application closing date is Dec. 15, 2015.
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The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
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AST
Wednesday, Nov. 18, 2015
Noon ET
Presented by CMS
More information: This webinar provides a brief look into the different tools and methods that may be utilized to display data, analyze data, and turn raw data into useful information. Register here!
AST
Wednesday, Nov. 18, 2015
1 p.m. ET
"Medical Ethics: Concepts and ILDA Practice" is the next webinar in the Education and Clinical Tools for the Independent Living Donor Advocate (ILDA) webinar series. The entire nine-webinar series, developed by the AST Live Donor Community of Practice, is free to AST members and their associates: just register with an AST member username and password at www.myAST.org/ILDA.
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You care about your transplant
patients. And so do we. That’s
why we’re introducing Astellas
Cares—a new program that
offers you customized tools,
educational resources, and
comprehensive support to help
your patients care for their
health. To register, visit
AstellasCares.com/Transplant
today.
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AASLD Liver Week
AASLD
Nov. 13-17, 2015 | San Francisco, CA
For more information: http://www.aasld.org/events-professional-development/liver-meeting
CEOT 2016 – Cutting Edge of Transplantation
Registration now open!
AST
Feb. 25-27, 2016 | Phoenix, AZ
For more information: http://2016.ceot.myast.org/
Now accepting abstracts!
CEOT abstract submission will be open until Sunday, Nov. 15. Abstracts will be presented in poster format. All abstracts presented at CEOT will receive focused attention and constructive feedback from attendees and faculty. Abstract presenters must register on their own and cover all of their travel costs.
Abstracts presented or accepted for presentation by a young investigator (defined as a medical student, resident, or fellow) at an AST or ASTS national meeting within the previous year may also be submitted to the American Transplant Congress (ATC).
American Journal of Transplantation
Implantation of embryonic stem cells (ESCs) and their differentiated derivatives into allogeneic hosts triggers an immune response that represents a hurdle to clinical application. We established in autoimmunity and in transplantation that CD3 antibody therapy induces a state of immune tolerance. Promising results have been obtained with CD3 antibodies in the clinic. In this study, we tested whether this strategy can prolong the survival of undifferentiated ESCs and their differentiated derivatives in histoincompatible hosts.
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Science
The shortage of organs for transplantation is a major barrier to the treatment of organ failure. While porcine organs are considered promising, their use has been checked by concerns about transmission of porcine endogenous retroviruses (PERVs) to humans. Here, we describe the eradication of all PERVs in a porcine kidney epithelial cell line (PK15). We first determined the PK15 PERV copy number to be 62.
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American Journal of Transplantation
We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated with acute rejection (AR) and AR-associated allograft failure. This variation in TAC troughs is due, in part, to differences in the frequency of the cytochrome P450 CYP3A5*3 allele (rs776746, expresses nonfunctional enzyme) between white and AA recipients; however, even after accounting for this variant, variability in AA-associated troughs is significant.
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Journal of Gastrointestinal Surgery
Antireflux surgery (ARS) has been associated with improved lung transplant outcomes. Pre-transplant ARS has been shown in small studies to improve pulmonary function among transplant candidates with gastroesophageal reflux disease (GERD). Although early post-transplant ARS has been shown to be effective in reducing chronic rejection, the optimal timing of ARS in transplant recipients remains unclear. The aim of this study is to evaluate the time to early allograft injury among lung transplant recipients by timing of ARS.
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American Journal of Transplantation
Clostridium difficile infection (CDI) is a considerable health issue in the United States and represents the most common healthcare-associated infection. Solid organ transplant recipients are at increased risk of CDI, which can affect both graft and patient survival. However, little is known about the impact of CDI on health services utilization posttransplantation. We examined hospital-onset CDI from 2012 to 2014 among transplant recipients in the University HealthSystem Consortium, which includes academic medical center–affiliated hospitals in the United States.
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