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Are you ready for the new kidney allocation system?
Join Gena Boyle and Richard Formica on Tuesday, Nov. 4 from 2-3 pm EST to learn strategies to improve recipient readiness and reduce disparities. Register today at - registration is free for AST members. During this webinar, the presenters will walk through the six major elements of the new kidney allocation system, including the essential preparations that transplant programs, histocompatibility laboratories, and OPOs need to take to prepare for implementation
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Changes in health care and vaccine updates: Two free webinars in November
Changes in the Health Care Environment and Transplantation: Wednesday, Nov. 12, 2014, 2-3 p.m. EST. Register today at - free for AST members. Understand changes in the healthcare environment and the effect of the ACA on transplantation.

Vaccine Updates in SOT: What's New, What's Standard of Care?: Tuesday, Nov. 18, 2-3 p.m. EST. Register today at - free for AST members. Transplant clinicians strive to prevent infection, and vaccination provides an opportunity to expand this effort. The current recommendations for vaccination, innovative research, and opportunity for advancing these efforts will be discussed.

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Submit your nomination for the AST Board of Directors
The AST Governance Committee is soliciting nominations for the 2015 AST Board of Directors. Qualified individuals should have had significant involvement in and service to the AST, should have demonstrated ability to think strategically, commit to working effectively within a collective decision-making body, and have knowledge of or experience with governance. Completed nominations must be submitted by 5 p.m. EST on Friday, Nov. 14, 2014. Late nominations will not be accepted. Additional information, including the nomination criteria and open positions can be found at:
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Final weekend to submit your abstract for CEOT
The Cutting Edge of Transplantation
Immunity and Inflammation: Engineering Cell, Gene, and Drug Therapies

Feb. 5-7, 2015
Sheraton Wild Horse Pass – Chandler, Arizona

For your convenience, the abstract submission site for the CEOT meeting will remain open through the weekend and will close on Monday, Nov. 3. Don’t miss out on the opportunity to share your research with experts in transplantation. Submit your basic, clinical or translational abstract on any transplantation or immunology topic by Nov. 3. The AST will award a limited number of Young Innovator Award travel grants to the highest scoring abstracts submitted by emerging professionals in transplantation.

Click here to register for CEOT 2015 and take advantage of early registration discounted rates! Or, learn more about this engaging meeting and view the preliminary program here.

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Raptor's mission is to develop and commercialize life-altering therapeutics that treat rare, debilitating, and often fatal diseases.
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.


CD28 negative T cells: Is their loss our gain?
American Journal of Transplantation
CD28 is a primary costimulation molecule for T cell activation. However, during the course of activation some T cells lose this molecule and assume a CD28-independent existence. These CD28− T cells are generally antigen-experienced and highly differentiated. CD28− T cells are functionally heterogeneous. Their characteristics vary largely on the context in which they are found and range from having enhanced cytotoxic abilities to promoting immune regulation. Thus, CD28 loss appears to be more of a marker for advanced differentiation regardless of the cytotoxic or regulatory function being conducted by the T cell.
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Key messages on Ebola virus disease
The Department of Health and Human Services’ Centers for Disease Control and Prevention (CDC) and Office of the Assistant Secretary for Preparedness and Response (ASPR) continues to work with other U.S. government agencies, the World Health Organization (WHO), and other domestic and international partners in an international response to the current Ebola outbreak in West Africa. Click here to view key messages about the outbreak and the response.
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  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE

Lifesaving liver transplantation for multi-organ failure caused by Bacillus cereus food poisoning
Pediatric Transplantation
Bacillus cereus is a spore-forming, gram-positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non-hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsipeptide toxin cereulide, which is produced in B. cereus contaminated food, particularly in pasta or rice.
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Risk factors for frailty in a large prevalent cohort of hemodialysis patients
The American Journal of the Medical Sciences
Although individuals with kidney disease, including those dependent on dialysis, often present clinically with signs and symptoms consistent with frailty, there is limited information about sociodemographic and clinical risk factors that may be associated. Seven hundred forty-five patients undergoing hemodialysisbetween 2009 and 2011 in 7 Atlanta dialysis clinics and 7 San Francisco bay area dialysis clinics were assessed using the validated Fried frailty index (recent unintentional weight loss, reported exhaustion, low grip strength, slow walk speed, low physical activity) that defines frailty as the presence of 3 or more criteria.
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Building new hearts: A review of trends in cardiac tissue engineering
American Journal of Transplantation
Cardiovascular disease (CVD) is the number one cause of death in the United States. However, few treatments for CVD provide a means to regain full cardiac function with no long-term side effects. Novel tissue-engineered products may provide a way to overcome the limitations of current CVD therapies by replacing injured myocardium with functioning tissue or by inducing more constructive forms of endogenous repair. In this review, we discuss some of the factors that should be considered in the development of tissue-engineered products, and we review the methods currently being investigated to generate more effective heart valves, cardiac patches and whole hearts.
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Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction
Clinical Transplantation
It is unclear whether a concomitant kidney transplant grants survival benefit to liver transplant (LT) candidates with renal dysfunction (RD). We retrospectively studied LT candidates without RD (n=714) and LT candidates with RD who underwent either liver transplant alone (RD-LTA; n=103) or simultaneous liver kidney transplant (RD-SLKT; n=68). RD was defined as renal replacement therapy (RRT) requirement or Modification of Diet in Renal Disease (MDRD) glomerular filtration rate (GFR).
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Missed last week's issue? See which articles your colleagues read most.

    Effect of dialysis initiation for preemptively listed candidates in the revised kidney allocation policy (American Journal of Transplantation)
A systematic review of the use of rituximab for desensitization in renal transplantation (Transplantation)
Medication misuse, non-adherence, and clinical outcomes among liver transplant recipients (Liver Transplantation)
Graft-versus-host disease after simultaneous pancreas-kidney transplantation: a case report and review of the literature (American Journal of Transplantation)

Don't be left behind. Click here to see what else you missed.

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Colby Horton, Vice President of Publishing, 469.420.2601
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Julie Bernhard, Executive Editor, 469.420.2647  
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