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Pulsatile pump decreases risk of delayed graft function in kidneys donated after cardiac death
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Organ storage techniques have been under scrutiny to determine the best preservation method, particularly in donation after cardiac death (DCD) kidneys. Conflicting literature on the benefit of pulsatile perfusion (PP) over cold storage (CS) warrants further investigation. Researchers analyzed the risk of developing delayed graft function (DGF) in recipients of DCD and donation after brain death (DBD) kidneys undergoing PP or CS. More

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AST awards program: Nominate your colleagues
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AST is soliciting nominations for AST Achievement Awards. The deadline for submissions is Nov. 19. AST sponsors a variety of achievement awards according to faculty rank in recognition of the AST members' achievements and contributions to the field of transplantation. AST members are encouraged to nominate deserving candidates for consideration. For complete information on awards eligibility criteria, application requirements, the review process and to submit a nomination, please visit the awards section of the AST website.

AST grants program: Submit an application for funding
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The American Society of Transplantation (AST) is now accepting applications for AST faculty and fellowship grants. The deadline for submissions is Nov. 19, 2012. AST grants support a wide range of basic and clinical research topics. AST members should bring this program to the attention of their colleagues in the field of transplantation at their institutions and support their applications. For complete information on grants eligibility criteria, application requirements, funding guidelines, the review process and to submit an application, please visit the grants section of the AST website.

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Kidney allocation proposal webinar
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UNOS is offering a webinar on Nov. 7 (2-3:15 p.m. EST) to address proposed changes to OPTN kidney allocation policy developed by the OPTN/UNOS Kidney Transplantation Committee. This webinar will review the proposal, explain how it will impact candidates and discuss potential changes to current policy to encourage dialogue and address questions within the transplant community. Learn more and register now!

Register now for AST's Cutting Edge of Transplantation and save 50 percent
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Registration is open for AST's Cutting Edge of Transplantation meeting taking place Feb. 14-16, 2013 at the Sheraton Wild Horse Pass near Scottsdale, Ariz. Register by Nov. 30 and receive 50 percent off of regular registration rates. The program features experts from basic, translational and clinical science, and tackles questions and challenges surrounding antibodies. Read more about the science and register today!

New on demand webcasts from AST's Timely Topics in Tx series
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Education when you want it, in less than 60 minutes! Now added to the Timely Topics in Transplantation on demand webcast series: ATC 2012 highlights in infectious disease, multi-organ transplantation, live donation and thoracic transplantation. These webcasts are free to AST members and can be viewed any time, at your leisure. Non-members may view the webcasts for only $25 each. View webcasts now...or later!

Athena Diagnostics

Genetic testing can be a cost-effective way to increase the number of living related donor transplants. Mutational analysis may help direct long-term treatment plans, including pre-operative screening of potential kidney transplant recipients and living related donors.
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MNX: Organ Transportation
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Pulmonary hypertension before first and second lung transplantation
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Pulmonary hypertension (PH) is frequently encountered in patients with advanced lung disease before the first and second lung transplantation. Researchers sought to determine whether there is any relationship between pulmonary hemodynamics obtained before first and second lung transplantation. They also assessed whether PH has prognostic implications in lung transplant patients going for second transplantation. More

Liver transplant survival higher among patients with NASH, HBV; lower for HCV, HCC
Healio    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Patients who underwent liver transplantation to treat nonalcoholic steatohepatitis, HBV or alcoholic liver disease had higher survival rates than those treated for HCV or hepatocellular carcinoma, according to data presented at the 2012 American College of Gastroenterology Annual Scientific Meeting. More

Antibody-mediated rejection
Current Opinion in Organ Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
AMR offers challenges of diagnosis and management, but recent advances in the detection of antibodies, the interpretation of endomyocardial biopsies and the use of therapies directed toward antibody production offer great promise. In the future, standardization of management across transplant centers will allow for clinical trials of the effectiveness of these therapies. More

Tax breaks do little to boost living kidney donation
Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Currently, 17 states offer a tax benefit to living kidney donors. However, these relatively new tax incentives appear to be having very little effect on live kidney donation. John Schieszer has the latest on the story in today's Medical Minute. More

Renal failure and transplantation following nonrenal solid-organ transplantation
Current Opinion in Organ Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to ESRD and the need for kidney transplantation. There is increased morbidity and mortality associated with chronic kidney disease (CKD) following nonrenal transplantation, but few large-scale studies have been conducted in pediatric patients. Challenges exist in monitoring renal function in chronically ill pediatric patients and estimating equations using creatinine overestimate glomerular filtration rates. Collaborative research is needed to define further the incidence of CKD following NRSOT. More

Optimizing outcomes for pediatric recipients
Liver Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
After liver transplantation (LT), the majority of children now grow into adulthood, with 10-year patient survival rates of 74 percent to 84 percent and graft survival rates of 62 percent to 72 percent according to United Network for Organ Sharing data. Graft and patient survival rates decrease for patients undergoing transplantation between the ages of 12 and 17 years, and this raises the importance of dedicated adolescent care and appropriate transitioning to adult services. As long-term medical complications are better managed, we need to focus on understanding the challenges for pediatric LT patients with respect to quality of life and health status. More

Delayed graft function is not associated with an increased incidence of renal allograft rejection
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Delayed graft function (DGF) is considered as a risk factor for renal allograft rejection, but this association might be confounded by diagnostic biases (e.g., higher biopsy frequency in patients with DGF, inclusion of clinically diagnosed rejection episodes and limited details on the rejection phenotype). This retrospective study including 329 deceased donor transplantations aimed to clarify a causal relationship between DGF and rejection. More

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