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AST president attends White House Oval Office signing of HOPE Act
AST
AST President Dr. Daniel Salomon joined President Obama Nov. 21 at the White House as he signed S. 330, the HIV Organ Policy Equity Act. The legislation, which enjoyed bipartisan and bicameral support, seeks to expand the supply of life-saving organs available for transplantation to the more than 118,000 individuals currently on the organ waitlist. Read the full press release here.
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SOCIETY NEWS


Free live webinars Dec. 5 and Dec. 19, on demand webinars available 24/7
AST
  • Dec. 5 at 1 p.m. EST: Ethics in Transplantation by Dr. Yolanda Becker, part of the Fellows Live Webinar Series (pre-registration is required)
  • Dec. 17 at 2 p.m. EST: Adherence Tools of Today and Tomorrow: Improving Adherence in the Challenging Transplant Patient, presented by Seth Heldenbrand, PharmD
All webinars are free for AST members, Timely Topics in Transplantation webinars are $25 each for non-members. There are live webinars in both the Timely Topics in Transplantation and Fellows Live Webinar Series through May of 2014!

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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


Cutting Edge of Transplantation registration is half off until Nov. 30
AST
Register for the Cutting Edge of Transplantation 2014 by Nov. 30 and save 50 percent off of regular registration rates. A doctoral AST member can attend for just $150! Don't miss the cutting edge program and the chance to engage in conversations with colleagues throughout this intimately-sized meeting.

This activity is jointly sponsored by Global Education Group and the American Society of Transplantation. Continuing education credit will be offered for physicians, nurses, pharmacists, and transplant coordinators. Click here for credit details. For information about accreditation of this program, please contact Global at 303-395-1782 or inquire@globaleducationgroup.com.

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Journal Club Dec. 13: "Kidney Allograft Survival After Acute Rejection, the Value of Follow-Up Biopsies"
AST
Join authors Dr. Fernando Cosio, and Mireille El Ters, MD, of the Mayo Clinic, Rochester for a review and discussion of their September 2013 AJT article. Pre-register today!
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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TRANSPLANT NEWS


Effects of cardiovascular comorbidity adjustment on SRTR risk-adjusted cox proportional hazard models of graft survival
Transplantation (login required)
The Scientific Registry of Transplant Recipients (SRTR) and the Centers for Medicare and Medicaid Services (CMS) determine expected graft survivals to identify potentially underperforming transplant centers. There has been recent interest in evaluating adjustments for comorbidities when performing these calculations. This study was performed to determine the influence that adjustment for pre-transplant cardiovascular disease comorbidity can have on risk-adjusted Cox models, such as those used by SRTR and CMS.
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The portal vein-variceal anastomosis: An important technique for establishing portal vein inflow
Clinical Transplantation (login required)
Adequate portal vein inflow is critical to successful orthotopic liver transplantation. While an end-to-end donor to recipient portal vein anastomosis is fashioned in the majority of liver transplant recipients, approximately 2 percent of recipients will require a complex vascular reconstruction due to inadequate recipient portal vein inflow. In this series, we describe our experience with five patients in which porto-variceal anastomosis was used to treat extensive porto-mesenteric thrombosis.
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PRODUCT SHOWCASE
 
Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
 


Randomized controlled pilot study of b cell-targeted induction therapy in HLA sensitized kidney transplant recipients
American Journal of Transplantation (login required)
Optimal induction regimens for patients at high risk for antibody and/or cell–mediated rejection have not been established. This pilot, prospective, randomized study evaluated addition of B cell/plasma cell–targeting agents to T cell–based induction with rabbit antithymocyte globulin in high immunologic risk renal transplant recipients.
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Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?
Clinical Transplantation (login required)
Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life.
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HCC-based transplants straining donor pool
Healio
The increase in the number of hepatocellular carcinoma patients in the United States being wait-listed for transplant is leading to a greater incidence of wait-listing for all individuals with hepatitis C, a speaker said. “The demand for liver transplantation for hepatocellular carcinoma is likely going to continue to rise and further strain our already limited donor pool," Dr. Jennifer A. Flemming, FRCP(C), MAS, of the University of California at San Francisco, said at The Liver Meeting. "This could influence HCC listing policy over the next decade and may push the transplant community to consider nontransplant alternatives [for HCC patients]."
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Study: Kidney transplant rejection drugs tied to pregnancy risks (HealthDay News via U.S. News and World Report)
Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection (Transplantation)
Transplant Surgeons: Meet your ABS MOC requirements through the AJT (American Journal of Transplantation)
Research: Old cancer drug may help prevent rejection after transplantation (By Joy Burgess)
Screening for new-onset diabetes after kidney transplantation: Limitations of fasting glucose and advantages of afternoon glucose and glycated hemoglobin (Transplantation)

Don't be left behind. Click here to see what else you missed.


Informed consent: What the patient heard
Transplantation (login required)
This article reports significant conceptual limitations in patient medical knowledge. In the course of customary comprehensive psychiatric evaluation, patients with end-stage renal and/or hepatic disease were asked about knowledge of benefits and side effects of required post-transplant medication. Liver transplant candidates were asked about their understanding of primary organ function and instructed in reference to components of Model for End-stage Liver Disease status on the deceased donor transplant list.
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Intrarenal resistive index after renal transplantation
The New England Journal of Medicine (login required)
The intrarenal resistive index is routinely measured in many renal-transplantation centers for assessment of renal-allograft status, although the value of the resistive index remains unclear. In a single-center, prospective study involving 321 renal-allograft recipients, the resistive index at baseline was measured, at the time of protocol-specified renal-allograft biopsies (3, 12 and 24 months after transplantation), and at the time of biopsies performed because of graft dysfunction.
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UMN surgeons perform region's first 'breathing lung' transplant
St. Paul Pioneer Press
University of Minnesota surgeons say they have performed the first lung transplant procedure in the Midwest using a new technology designed to better preserve lungs once they've been donated. The so-called "breathing lung" transplant was performed last week in Minneapolis at the University of Minnesota Medical Center, Fairview. A 51-year-old Minnesota man with emphysema underwent the double-lung procedure. The organs spent two hours in the experimental device while being transported from the donor's hospital.
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Prognostic implications of preoperative aerobic capacity and exercise oscillatory ventilation after liver transplantation
American Journal of Transplantation (login required)
The aim of a recent study was to determine preoperative aerobic capacity (oxygen uptake [V′O2]) and prevalence of exercise oscillatory ventilation (EOV), underlying clinical characteristics of patients with EOV, and significance of reduced aerobic capacity and EOV in predicting mortality after liver transplantation. Authors prospectively studied 263 patients who underwent elective liver transplantation. Patients were followed up for 1 year. Despite minor impairment of resting cardiopulmonary function, preoperative aerobic capacity was reduced
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