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Variations in institutional staffing and clinical practice are predictive of center-specific 1-year survival post-transplant
The Journal of Heart and Lung Transplantation
The accuracy of various risk models to predict early post-transplant mortality is limited by the type, quality, and era of the data collected. Most models incorporate a large number of recipient-derived and donor-derived variables; however, other factors related to specific institutional practices likely influence early mortality. The goal of this study was to determine if the addition of institutional practice variables would improve the predictive accuracy of a recipient/donor risk model in a modern cohort of heart transplant recipients.
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AST National Office: Thanksgiving holiday schedule
AST
In observance of the Thanksgiving holiday (USA), the AST National Office will be closed on Thursday, Nov. 27 and Friday, Nov. 28. The office will resume regular business hours on Monday, Dec. 2.
Last chance to get half off Cutting Edge of Transplantation registration!
AST
Register for the Cutting Edge of Transplantation 2014 by Nov. 30 and save 50 percent off of regular registration rates. A doctoral AST member can attend for just $150! Don't miss the cutting edge program and the chance to engage in conversations with colleagues throughout this intimately-sized meeting.
If you have important research that affects graft survival (in the broadest sense possible), we want to hear about it at CEOT 2014. Submit your abstracts by Nov. 30 to be considered; you may even qualify for a $500 Young Innovator Award travel grant.
This activity is jointly sponsored by Global Education Group and the American Society of Transplantation. Continuing education credit will be offered for physicians, nurses, pharmacists, and transplant coordinators. Click here for credit details. For information about accreditation of this program, please contact Global at 303-395-1782 or inquire@globaleducationgroup.com.
Journal Club Dec. 13: "Kidney Allograft Survival After Acute Rejection, the Value of Follow-Up Biopsies"
AST
Join authors Fernando Cosio, MD, and Mireille El Ters, MD, of the Mayo Clinic, Rochester, for a review and discussion of their September 2013 AJT article. Pre-register today!
PRODUCT SHOWCASE
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The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
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The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation
The Journal of Heart and Lung Transplantation
During the past 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading and reporting of cardiac antibody-mediated rejection.
Latest technology offers promise for patients awaiting kidney transplants
Joy Burgess
 Many patients today spend years waiting for the lifesaving transplant they require. Even with live organ donors stepping in to offer organs for loved ones, there still are not enough organs for patients awaiting transplantation. This lack of organs has led scientists to search for ways to grow or manufacture transplantable organs to fit this need. From biokidneys to 3-D printing, scientists have taken several approaches recently to solve this problem.
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For nearly 30 years, physicians have trusted Viracor-IBT Laboratories to provide accelerated results, specialized expertise and exceptional service in transplant testing. Learn more at www.viracoribt.com.
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To find out how to feature your company in the AST eNewsletter and other advertising opportunities, Contact Tom Crist at 972-402-7724.
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When the living and the deceased cannot agree on organ donation
American Journal of Transplantation (login required)
The legal concept of first person authorization (FPA) is based on the principle that a decision by a person with decision-making capacity should be respected even after he or she dies. Although the transplant community largely supports this concept, its implementation has not been universal.
Mechanism protects against rejection in xenotransplantation
ScienceDaily
Researchers at the Bellvitge Institute of Biomedical Research led by Cristina Costa from the New Therapies on Genes and Transplantation group have shown that inhibition of one of the basic components of the complement system protects chondrocytes (cartilage cells) from porcine rejection of xenotransplantation.
PRODUCT SHOWCASE
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Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
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Pre-operative health status and outcomes after continuous-flow left ventricular assist device implantation
The Journal of Heart and Lung Transplantation (login required)
The findings of a new study suggest that pre-operative health status has limited association with outcomes after left ventricular assist device implantation. Although these data require further study in a diverse population, mechanical circulatory support may represent a relatively unique clinical situation, distinct from heart failure and other cardiac surgeries, in which heart failure-specific health status measures may be largely reversed.
Study shows how thymoglobulin reduces rejection risk in kidney transplant
News Fix
In a new trial carried out by researchers at Washington University School of Medicine, the two most common antibodies used in organ transplants — thymoglobulin and basiliximab — are compared for their ability to reduce rejection of a new kidney.
Experiment seeks to allow lung donations from people who die at home
The Associated Press via The Herald
It's a little-known twist of nature: Your lungs can live on for a while after you die. The air left inside keeps them from deteriorating right away as other organs do. An innovative experiment now aims to use that hour-or-more window of time to boost lung transplants by allowing donations from people who suddenly collapse and die at home instead of in a hospital.
Missed last week's issue? See which articles your colleagues read most.
Risk for transmission of naegleria fowleri from solid organ transplantation
American Journal of Transplantation (login required)
Primary amebic meningoencephalitis (PAM) caused by the free-living ameba (FLA) Naegleria fowleri is a rare but rapidly fatal disease of the central nervous system (CNS) affecting predominantly young, previously healthy persons. No effective chemotherapeutic prophylaxis or treatment has been identified. Recently, three transplant-associated clusters of encephalitis caused by another FLA, Balamuthia mandrillaris, have occurred, prompting questions regarding the suitability of extra-CNS solid organ transplantation from donors with PAM.
Interferon-Gamma producing regulatory T cells as a diagnostic and therapeutic tool in organ transplantation
International Reviews of Immunology via Informa Healthcare
There is increasing evidence that IFNg plays a major role in both induction of Tregs as well as immunosuppression mediated by IFNg-producing Tregs. The present review focuses on a small subset of iTregs that produces IFNGcomprises only 0.04 percent of all CD4+ T lymphocytes in the blood of healthy individuals and increases strongly during an immune response. Goals of further research are the development of appropriate diagnostic tests for rapid and exact determination of immunosuppressive IFNg+ iTregs, as well as the induction and propagation of stable immunosuppressive IFNg+ Tregs that establish and maintain good long-term graft function in transplant recipients.
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