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Targeting cells causing split tolerance allows fully allogeneic islet survival with minimal conditioning in NOD mixed chimeras
American Journal of Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Donor-specific tolerance induced by mixed chimerism is one approach that may eliminate the need for long-term immunosuppressive therapy, while preventing chronic rejection of an islet transplant. However, even in the presence of chimerism it is possible for certain donor tissues or cells to be rejected whereas others from the same donor are accepted (split tolerance). In a recent study, researchers used radiation chimeras and found that the radiosensitive component of NOD has a greater role in the split tolerance NOD mice develop. More

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 SOCIETY NEWS


Cutting Edge of Transplantation (CEOT): Buy 1, get 1 half off registration rates
AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first annual CEOT meeting taking place Feb. 14-16, 2013, brings together experts to tackle the controversies and challenges related to B cells and antibodies in transplantation. For a limited time, you can buy one registration and get one half off. This is a great opportunity for you and your colleagues to save on registration for this event. View the program, which includes over 30 speakers, and then register.

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Live webinar Dec. 12: 'Transplant Cost Report 101... Understanding the Basics'
AST    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Go to a-s-t.org/business to register for the next live webinar in the Business of Transplantation Webinar Series: It's free for AST members and only $50 for non-members. Join Alexander Aussi, BSN, MBA, at 2 p.m. EST on Wednesday, Dec. 12 to learn about transplant cost reports, acquisition services and the Medicare ratio.

 TRANSPLANT NEWS


Acidosis in renal transplant patients may be related to diet
Renal & Urology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Diet may contribute to metabolic acidosis in renal transplant recipients (RTRs), according to investigators. In a study of 707 (RTRs), Dr. Else van den Berg, of University Medical Center Groningen in Groningen, the Netherlands, and colleagues found that patients with high intake of animal protein, such as from meat and fish, and low intake of fruits and vegetables had significantly lower serum bicarbonate and serum pH. More

Transjugular intrahepatic portosystemic shunt for hepatitis C virus-related portal hypertension after liver transplantation
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A recent study reviewed 19 consecutive liver transplant (LT) patients with hepatitis C virus (HCV)-related graft recurrent hepatitis who underwent transjugular intrahepatic portosystemic shunt (TIPS) at a median interval of 21 months (range: 5–50) from LT. Indications were refractory ascites in 11 patients (57.9 percent), hydrothorax in six (31.6 percent), and both in two (10.5 percent). Researchers concluded that TIPS may be used to treat complications secondary to HCV. More



Acute liver failure, acetaminophen overdose patients displayed reduced quality of life
Healio    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The health-related quality of life for long-term survivors of acute liver failure, particularly among acetaminophen overdose patients, was significantly lower than that of the U.S. general population according to research presented at The Liver Meeting. More

Spain remains world transplant leader
Fox    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Spain continues to be the world leader in organ donations and transplants despite the country's economic woes, according to the director of the National Transplant Organization. With the figures available up to November, Spain maintains its world leadership after beating its own record last year with a total of 4,212 transplants. More


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The role of belataceptin transplantation: Clinical trials in the context of other new biological immunosuppressant agents
Clinical Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Although conventional immunosuppressive agents such as calcineurin inhibitors have substantially reduced the risk of acute rejection, they have had less impact on the long-term survival. This is likely to be related to the adverse effects of such agents in terms of impaired renal function, hypertension and dyslipidemia. More

Relevance of cohort studies for the study of transplant infectious diseases
Current Opinion in Organ Transplantation (subscription required)    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The debate on the merits of observational studies as compared with randomized trials is ongoing. This review postulates an important role for cohort studies, which should not be viewed as inferior but complementary to established research tools, in particular randomized trials. More
 



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