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As 2013 comes to a close, AST would like to wish its members, partners and other industry professionals a safe and happy holiday season. As we reflect on the past year for the industry, we would like to provide the readers of the AST eNews a look at the most accessed articles from the year. Our regular publication will resume Jan. 3.


Obesity and its impact on transplantation and alloimmunity
Transplantation (login required)
From July 12: Obesity has become an increasing problem in healthcare worldwide with far-reaching consequences. More obese patients with irreversible end-stage organ failure undergo organ transplantation, and organs from obese donors are more frequently used. A growing body of evidence suggests more frequent postoperative complications and inferior patient and graft survival linked to obesity. More recently, adipose tissue has been linked to chronic inflammatory processes potentially impacting alloimmune responses and graft quality.
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Living donor versus deceased donor liver transplantation: A surgeon-matched comparison of recipient morbidity and outcomes
NCBI
From June 21: Informed consent for living donor liver transplantation (LDLT) requires that patients are provided with accurate information on the relative benefits and risks of this procedure compared with deceased donor liver transplantation (DDLT). There is strong evidence to suggest that LDLT facilitates timely transplantation to patients; however, information on the relative morbidity and death risks after LDLT as compared with DDLT is limited. A matched cohort comparison was performed matching recipients for age, MELD, date of transplant, gender, primary diagnosis and recipient surgeon.
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Trial: Transplanting the highly sensitized patient
NCBI
From Oct. 11: Humoral sensitization to antigens of the human leukocyte antigen and ABO systems remains one of the largest barriers to further expansion in renal transplantation. This barrier translates into prolonged waiting time and a greater likelihood of death. The number of highly sensitized patients on the renal transplant waiting list continues to increase. This review focuses on the options available to these patients and speculates on future directions for incompatible transplantation.
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PRODUCT SHOWCASE
  UCLA Immunogenetics Center

The UCLA Immunogenetics Center (UIC) provides comprehensive testing for organ and tissue transplantation. Transplant testing has a long history at UCLA. HLA typing was pioneered here in the 1960's. The development of the microcytoxicity test in 1964 marked the beginning of international testing and standardization of HLA typing. The UCLA Immunogenetics Center has retained its leadership position in HLA research, and in the development of accompanying diagnostic testing. MORE
 


Cardiac troponin T before and after kidney transplantation: Determinants and implications for posttransplant survival
American Journal of Transplantation (subscription required)
From March 7: Pretransplant cardiac troponin T (cTnTpre) is a significant predictor of survival postkidney transplantation. Researchers assessed correlates of cTnT levels pre- and posttransplantation and their relationship with recipient survival. A total of 1206 adult recipients of kidney grafts between 2000 and 2010 were included.
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Treatment of steroid-resistant acute renal allograft rejection with alemtuzumab
American Journal of Transplantation (subscription required)
From Jan. 24: Steroid-resistant renal allograft rejections are commonly treated with rabbit antithymocyte globulin (RATG), but alemtuzumab could be an effective, safe and more convenient alternative. Adult patients with steroid-resistant renal allograft rejection treated with alemtuzumab (15–30 mg s.c. on two subsequent days) from 2008 to 2012 were compared to patients treated with RATG.
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The national program for deceased organ donation in China
Transplantation (login required)
From July 5: China has developed a new national program for deceased-organ donation to address the need for organ transplantation in the country. The program adheres to the World Health Organization guiding principles, is compliant with the Declaration of Istanbul, and respects the cultural and social values of the Chinese people. The experience of pilot trials conducted between 2010 and 2012 was evaluated to generate a comprehensive design of a national program of organ donation and transplantation for implementation throughout China.
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Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies
NCBI
From May 31: In the United States, more than 2600 kidneys are discarded annually, from the total number of kidneys procured for transplant. It has been hypothesized that this organ pool may be used as a platform for renal bioengineering and regeneration research. The purpose of the current study was to test if the same strategy can be applied to discarded human kidneys in order to obtain human renal ECM scaffolds. The results show that the sodium dodecylsulfate-based decellularization protocol completely cleared the cellular compartment in these kidneys, while the innate ECM framework retained its architecture and biochemical properties.
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PRODUCT SHOWCASE
 
Astellas is entering its 20th year focusing on transplant immunology. Today we remain steadfast in our commitment to advancing the field. Tomorrow we will seek new possibilities to help improve the transplant experience. Together. Please visit astellas.us
 


Acute hepatitis and liver failure following the use of a dietary supplement Intended for weight loss or muscle building
CDC
From Oct. 19: On Sept. 9, the Hawaii Department of Health (HDOH) was notified of seven patients with severe acute hepatitis and fulminant liver failure of unknown etiology. Patients were previously healthy and sought medical care during May-September 2013. Clinicians reported that the seven patients had all used OxyELITE Pro, a dietary supplement marketed for weight loss and muscle gain, before illness onset. The HDOH, with the CDC and the Food and Drug Administration (FDA), initiated a public health investigation including patient interviews, medical chart reviews and collection of supplement samples for analysis.
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Groundbreaking surgery for girl born without windpipe
The New York Times
From May 3: Using plastic fibers and human cells, doctors have built and implanted a windpipe in a 2 ½-year-old girl — the youngest person ever to receive a bioengineered organ. The surgery, which took place on April 9 at Children's Hospital of Illinois is only the sixth of its kind and the first to be performed in the United States. It was approved by the Food and Drug Administration under rules that allow experimental procedures when otherwise the patient has little hope of survival.
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Nonalcoholic fatty liver disease epidemic and its implications for liver transplantation
Transplantation (login required)
Dec. 6: Nonalcoholic steatohepatitis (NASH) is increasingly recognized as the most common chronic liver disease worldwide. The aim of this study is to investigate the transplantation trends of liver transplant recipients with NASH. Using the United Network for Organ Sharing database, study authors found a steady increase in LT rate especially in those more than 65 years old.
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Colby Horton, Vice President of Publishing, 469.420.2601
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Courtney Hodges, Content Editor, 972.402.2604   
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