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Sept. 4, 2020

SOCIETY NEWS

Write Better Research Grants: On-Demand Workshop AST The AST Research Network is offering an on-demand webinar on research grant writing. This 1-hour workshop shares tips on how to write a successful grant application from two experienced grant reviewers. REGISTER TODAY

In Memoriam: George Melville Williams, MD AST The AST was saddened to hear about the recent passing of transplant surgeon, George Melville Williams, MD (1930 – 2020). Dr. Williams passed away on August 26, 2020, at the age of 89. READ MORE

In Memoriam: Dr. John S. Najarian AST The AST was saddened to hear about the recent passing of transplant pioneer, Dr. John S. Najarian (1927–2020). Dr. Najarian passed away on September 1, 2020, at the age of 92. READ MORE

SPONSORED VIDEO Kidney Transplant Patients and Immunosuppression Now you can see the different ways that different formulations are released and absorbed in the gastrointestinal system. You’ll also have the opportunity to explore comparative pharmacokinetic results in rapid metabolizers, efficacy data over 2 years, and safety information. Watch Video WATCH VIDEO

OPTN Opportunities OPTN The OPTN has several open opportunities for your consideration including board and committee positions, public comment, surveys, and virtual regional meetings. READ MORE

SPONSORED CONTENT Promoted by Natera • Natera Announces New Prospera Data at ATC Showcasing Innovation in Cell-free DNA • Natera's ProReach Program: Remote care for Prospera patients including routine labs • Natera receives final Medicare Coverage for Prospera transplant assessment test • New ProActive Registry: largest clinical utility study evaluating Prospera in >3,000 kidney transplant patients • Global, prospective multicenter study evaluating MMDx and Prospera under the leadership of Dr. Philip Halloran is now enrolling

FOCIS 2020 Annual Meeting FOCIS FOCIS invites you to attend the 20th anniversary of their annual meeting with an innovative lineup of topics and presenters. More than 20 scientific sessions, presented by more than 50 top clinicians and researchers from around the globe, will cover cutting-edge topics across immunology and its related fields. The opening session will feature Dr. Anthony Fauci, and the keynote addresses will be given from Nobel Laureate Dr. Tasuku Honjo, Dr. Federica Sallusto, and Dr. Irv Weissman. Presentations will be given from FOCIS founders Dr. David Hafler and Dr. Garry Fathman, Dr. Maria-Grazia Roncarolo, Dr. Carl June, Dr. Marc Feldman and Dr. Gerald Nepom, as well as a prospective look into the next 20 years. READ MORE

COVID-19 and Transplantation: AJT Articles AST In the interest of facilitating patient care and advancing science and ensuring that accurate knowledge and experience is available to all during this current time of crisis, AJT has been expediting review of all papers dealing with COVID-19, as well as making them free to access for all. READ MORE

PRODUCT SHOWCASE The First and Only FDA-cleared digestive enzyme cartridge to Hydrolyze Fats in Enteral Formula RELiZORB mimics the function of pancreatic lipase and delivers absorbable fats to your patients. Indicated for use in pediatric patients (ages 5 years and above) and adult patients to hydrolyze fats in enteral formula. Learn more at relizorb.com REL20-310 LEARN MORE

AST Research Network AST The AST Research Network is now accepting applications for its annual career development grants cycle! The purpose of these grants is to foster the training of early career investigators who have the potential to contribute to transplant science/immunobiology and/or treatment of transplant recipients. The grants encourage continued commitment of high-quality applicants to their careers in transplantation. Applications are accepted in basic, clinical, and translational research. READ MORE

SPONSOR SPOTLIGHT

UPCOMING EDUCATION EVENTS

Effects of mTOR inhibitor-related Proteinuria on Progression of Cardiac Allograft Vasculopathy and Outcomes Among Heart Transplant Recipients AST Date and Time: Tuesday, September 8, 2020, from 2:00 PM ET to 3:00 PM ET Hosted by: The AST TCC COP and TxPharm COP REGISTER NOW

FEATURED ARTICLE Immunosuppression in de novo kidney transplant recipients Promoted by Veloxis Pharmaceuticals There are many factors that may put a graft at risk, such as infections, nephrotoxicity, declining adherence, and inadequate immunosuppression. It can be difficult to achieve a balance between overimmunosuppression and underimmunosuppression in kidney transplant patients, putting patients at risk. READ MORE

Race, Racism, and Access to Renal Transplantation among African Americans AST Date and Time: Wednesday, September 16, 2020, at 2:00 PM ET Hosted by: TxAQM COP REGISTER NOW

Three‐year Outcomes from the Cradle Study in De Novo Pediatric Kidney Transplant Recipients Receiving Everolimus with Reduced Tacrolimus and Early Steroid Withdrawal AST Date and Time: Thursday, October 1, 2020, from 3:00 PM ET to 4:00 PM ET Hosted by: TxPharm COP and Pediatrics COP REGISTER NOW

PRODUCT SHOWCASE

Reach Your Prospects Every Week Thousands of industry professionals subscribe to AST's eNews, which allows your company to push messaging directly to their inboxes and take advantage of the association's brand affinity. Connect with Highly Defined Buyers and Maximize Your Brand Exposure! LEARN MORE Now offering Mobile Phlebotomy Labs@HOME is a mobile phlebotomy in-home blood draw service to aid in specimen collection directly from a patient's home. Clinicians can order and customize a number of infectious disease and transplant-relatedtesting remotely LEARN MORE

TRANSPLANT NEWS

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells ScienceDirect The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been previously described. READ MORE

SPONSOR SPOTLIGHT

Time to Conversion to an Everolimus‐Based Regimen: Renal Outcomes in Liver Transplant Recipients From the EVEROLIVER Registry Liver Transplantation Long‐term use of a calcineurin inhibitor (CNI)‐based regimen is one of the major reasons for chronic renal failure in liver transplant recipients (LTR). EVEROLIVER registry evaluated renal function in LTR who were converted to everolimus. READ MORE

Changes in Liver Transplant Center Practice in Response to Coronavirus Disease 2019: Unmasking Dramatic Center-Level Variability Vatche Agopian, MD ; Elizabeth Verna, MD, MSc; David Goldberg, MD, MSCE The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been devastating to health care delivery in many parts of the US and has had a significant impact on organ transplantation. With shelter-inplace orders, outpatient clinics transitioned to telemedicine, and the threat of hospitals being overrun with COVID-19 patients, liver transplant programs have been faced with the challenge of balancing patient and staff safety while operating in a resource limited environment. READ MORE

Effects of Body Mass Index on Kidney Transplant Outcomes Are Significantly Modified by Patient Characteristics American Journal of Transplantation Body mass index (BMI) is a known risk factor associated with kidney transplant outcomes and is incorporated for determining transplant candidate eligibility. However, BMI is a coarse health measure and risks associated with BMI may vary by patient characteristics. READ MORE

Opinions of African American Adults About the Use of Apolipoprotein L1 (ApoL1) Genetic Testing in Living Kidney Donation and Transplantation American Journal of Transplantation Apolipoprotein L1 (ApoL1) predictive genetic testing for kidney disease, and its emerging role in transplantation, remains controversial as it may exacerbate underlying disparities among African Americans (AAs) at increased risk. READ MORE

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