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Duration beyond liver transplant improved patients' tolerance to immunosuppression cessation
Liver transplant recipients are more likely to tolerate withdrawal from immunosuppressant therapy if cessation is initiated well after transplantation, according to recent study results. Researchers gradually discontinued immunosuppressive drug therapy during a 6- to 9-month period in 102 stable liver transplant recipients. All participants had undergone transplantation more than 3 years earlier and had no history of autoimmune liver disease.
Make Your Voice Heard
Voting has opened for the 2013 ASTS Officer & Councilor Elections. All eligible voting members should have received an email with a unique link to cast their votes for the President-Elect and 3 Councilor-at-Large positions by April 29, 2013.
ASTS Events at ATC
If you are planning to attend the American Transplant Congress in Seattle May 18–22, don't forget these ASTS events:
- Presentation of the Pioneer Award at 10 a.m. on Sunday, May 19, to Ronald Busuttil, MD, PhD
- Presentation of the ASTS research grants at 9:15 a.m. on Tuesday, May 21
- ASTS Presidential Address at 9:30 a.m. on Tuesday, May 21
- ASTS Business Meeting at 5:45 p.m. Tuesday, May 21 (members only), followed by the ASTS Member Reception at 7:00 p.m.
Pretransplant cancers might be overlooked
Renal & Urology News
Many cancers found after kidney transplantation might have been present prior to surgery and possibly could have been detected during the pretransplant workup, according to results from a new study. In a group of 3,524 kidney transplant recipients in Quebec, 36 neoplasias were detected within a year of surgery. Of these, 16 (44 percent) may have been present before transplantation and could have been detected during the routine pretransplant workup.
Practical guidance on the evaluation of potential organ donors for meningoencephalitis
The Organ Procurement and Transplantation Network
The recent transmission of rabies from an infected donor to an organ recipient is a reminder that potential organ donors need to be carefully evaluated for the presence of meningoencephalitis. The Organ Procurement and Transplantation Network, together with the United Network for Organ Sharing, has developed this document detailing the Ad Hoc Disease Transmission Advisory Committee's (DTAC) practical guidance on the evaluation of potential organ donors for meningoencephalitis during the screening procedure.
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Local access to subspecialty care influences the chance of receiving a liver transplant
Liver Transplantation (subscription required)
Prior studies have examined the impact of demographic factors on liver transplant outcomes. These factors may be surrogate markers for access to medical care. A recent study investigated physician density in referred patients' hospital service areas (HSAs) as a factor in patients' probability of receiving a liver transplant. Researchers recently performed a retrospective review of patients referred for liver transplantation from 2002-2010.
CDC probes rabies transplant mystery: Why did 3 of 4 recipients survive, unlike 2004 case?
The Associated Press via The Washington Post
The federal Centers for Disease Control and Prevention is trying to understand why three of the four people who got organs from a rabies-infected donor in 2011 didn't develop the disease, the agency's top rabies expert said.
Investigators have been puzzled because four recipients in a similar 2004 case all died of rabies within weeks. The answer could lie in the strain of rabies involved, the amount of virus in the transplanted organs, the medical history of the recipients or their genetic makeup, CDC veterinarian Richard Franka said in a telephone interview.
Vitamin D improved kidney function in transplant patients
Vitamin D supplementation could prove helpful for patients who have had a kidney transplantation, according to research published in the Journal of the American Society of Nephrology. Researcher Frank Bienaime, MD, of the Université Paris Descartes and INSERM and Assistance Publique-Hopitaux de Paris, and colleagues examined 634 patients two to four months after renal transplantation during a 5-year period.
Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
Liver Transplantation (subscription required)
Recurrent hepatitis C virus (HCV) infection is associated with accelerated fibrosis rates after liver transplantation (LT) and is the leading cause of graft failure. Furthermore, distinguishing recurrent HCV from acute cellular rejection (ACR) can be problematic, and this can lead to inappropriate treatments and adverse outcomes. It has been hypothesized that intragraft microRNA (miRNA) expression profiles could distinguish the severity of recurrent HCV and differentiate recurrent HCV from ACR. Researchers have established meticulously matched post-LT patient cohorts in order to derive robust global miRNA expression profiles and minimize the impact of variables known to influence HCV recurrence.
HCV coinfection not predictive of kidney disease in liver transplant recipients with HIV
Liver transplant recipients with HIV and hepatitis C were not at increased risk for chronic kidney disease compared with those with HIV alone, but coinfection may be linked to more advanced disease, according to recent results. Researchers evaluated data from 81 patients coinfected with HCV and HIV and 35 with HIV who underwent orthotopic liver transplantation between 2003 and 2010. Chronic kidney disease (CKD) prevalence before transplantation and one and three years after was determined in each group, with a median follow-up of 3.6 years.
Organogenesis for kidney regeneration
Current Opinion in Organ Transplantation (subscription required)
The kidney has an elaborate and complicated structure comprising several cell types. Damage or destruction of the kidney thus necessitates reconstruction of all the component cell types to regenerate a functional three-dimensional renal structure. Therefore, despite all the recent advances in the understanding of and technical approaches to stem cell and developmental biology, the anatomical complexity of the renal system makes de novo kidney regeneration the most difficult challenge for organ regenerative therapy.
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