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Study shows how thymoglobulin reduces rejection risk in kidney transplant
In a new trial carried out by researchers at Washington University School of Medicine, the two most common antibodies used in organ transplants — thymoglobulin and basiliximab — are compared for their ability to reduce rejection of a new kidney.
ASTS Council nominations close tonight!
You have until midnight tonight to submit your nominations for the following positions on the ASTS Council: 1 president-elect, 1 secretary, and 3 councilor-at-large positions. Terms begin in July 2014.
HOPE Act signed into law
American Society of Transplant Surgeons President-Elect Peter G. Stock, MD, PhD, was among those present at the White House on November 21 as President Obama signed the HIV Organ Policy Equity Act into law. The HOPE Act reverses the current legal ban, enacted in 1988, on the use of HIV-positive organs for HIV-positive individuals in need of a donor organ.
All ASTS members recently received an email invoice for this year's dues. You can pay online at ASTS.org — if you need your login information, click on the "log in" button on the home page and then use the "forgot password?" link.
Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?
Clinical Transplantation (login required)
Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life.
Informed consent: What the patient heard
Transplantation (login required)
This article reports significant conceptual limitations in patient medical knowledge. In the course of customary comprehensive psychiatric evaluation, patients with end-stage renal and/or hepatic disease were asked about knowledge of benefits and side effects of required post-transplant medication. Liver transplant candidates were asked about their understanding of primary organ function and instructed in reference to components of Model for End-stage Liver Disease status on the deceased donor transplant list.
Interferon-Gamma producing regulatory T cells as a diagnostic and therapeutic tool in organ transplantation
International Reviews of Immunology via Informa Healthcare
There is increasing evidence that IFNg plays a major role in both induction of Tregs as well as immunosuppression mediated by IFNg-producing Tregs. The present review focuses on a small subset of iTregs that produces IFNGcomprises only 0.04 percent of all CD4+ T lymphocytes in the blood of healthy individuals and increases strongly during an immune response. Goals of further research are the development of appropriate diagnostic tests for rapid and exact determination of immunosuppressive IFNg+ iTregs, as well as the induction and propagation of stable immunosuppressive IFNg+ Tregs that establish and maintain good long-term graft function in transplant recipients.
Mechanism protects against rejection in xenotransplantation
Researchers at the Bellvitge Institute of Biomedical Research led by Cristina Costa from the New Therapies on Genes and Transplantation group have shown that inhibition of one of the basic components of the complement system protects chondrocytes (cartilage cells) from porcine rejection of xenotransplantation.
Risk for transmission of naegleria fowleri from solid organ transplantation
American Journal of Transplantation (login required)
Primary amebic meningoencephalitis (PAM) caused by the free-living ameba (FLA) Naegleria fowleri is a rare but rapidly fatal disease of the central nervous system (CNS) affecting predominantly young, previously healthy persons. No effective chemotherapeutic prophylaxis or treatment has been identified. Recently, three transplant-associated clusters of encephalitis caused by another FLA, Balamuthia mandrillaris, have occurred, prompting questions regarding the suitability of extra-CNS solid organ transplantation from donors with PAM.
HCC-based transplants straining donor pool
The increase in the number of hepatocellular carcinoma patients in the United States being wait-listed for transplant is leading to a greater incidence of wait-listing for all individuals with hepatitis C, a speaker said. “The demand for liver transplantation for hepatocellular carcinoma is likely going to continue to rise and further strain our already limited donor pool," Dr. Jennifer A. Flemming, FRCP(C), MAS, of the University of California at San Francisco, said at The Liver Meeting. "This could influence HCC listing policy over the next decade and may push the transplant community to consider nontransplant alternatives [for HCC patients]."
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