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SciTechDaily
France and the United States, two countries hit hard by the novel coronavirus, have experienced a tremendous reduction in the number of organ donations and solid organ (kidney, liver, heart, and lung) transplant procedures since the onset of the COVID-19 pandemic, according to a new study. By early April, transplant centers in both countries were conducting far fewer deceased donor transplants compared to just one month earlier, with the number of procedures dropping by 91 percent in France and 50 percent in the United States.
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Journal of the American Society of Nephrology
For the transplant specialist, microbiology represents a series of potential tools with which to probe the human immune system. We assume that, for each pathogen, the immunocompromised host will demonstrate reduced resistance to infection, atypical clinical signs and symptoms, more rapid progression, and greater mortality. There are few data that guide the clinician for modification of immunosuppressive regimens for specific infections. Confronted with COVID-19, clinicians have strong opinions regarding the best immunosuppressive manipulations on the basis of extensive, but uncontrolled experience with other infections.
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Regulatory Focus
The US Food and Drug Administration on May 7 finalized guidance on developing drugs to treat or prevent cytomegalovirus, a common virus in the beta-herpes virus group, in patients who have undergone solid organ or hematopoietic stem cell transplantation.
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Gastroenterology & Endoscopy News
For a person with cirrhosis, a liver transplant can mean the difference between life and death. But if the person hoping to receive lifesaving treatment happens to be a woman, she is more likely to die waiting for that liver than if she were a man.
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Veloxis Pharmaceuticals
Follow the journeys of kidney transplant patients who transitioned to a different immunosuppression regimen. After talking with their doctors about their experiences with other options, they decided to make a switch.
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The Journal of Heart and Lung Transplantation
Donor heart allocation in the United States is managed by United Network for Organ Sharing; however, donor heart selection is managed by individual transplant centers. Consequently, donor offer acceptance practice varies significantly: in 2017-2018 the Scientific Registry of Transplant Recipients Offer Acceptance Ratio ranged from 0.22 to 3.69.1 This study sought to determine if local competition was associated with donor selection practices for adult heart transplantation.
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American Journal of Transplantation
The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR report to further clarify the expectations, limitations, perceptions, and utility of alloimmune assays that are currently in use or in development for risk assessment in the setting of organ transplantation. The goal was to determine the precision and clinical feasibility/utility of such assays in evaluating both memory and primary alloimmune risks.
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Veloxis Pharmaceuticals
Did you know there’s a transplant support system to help patients and providers with best-in-class assistance and resources? This ongoing support system assists with benefit investigation, prior authorization assistance, coordination with specialty pharmacies, prescription fulfillment navigation, and CoverMyMeds® access. There’s also a $0 co-pay card to overcome financial barriers.
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Clinical Transplantation
Effectiveness of uncontrolled donation after circulatory death has been recently reported to be 75 percent, according to data coming from some European countries in 2016, but few data are to date available on this topic.
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American Journal of Transplantation
Non‐invasive biomarker profiles of acute rejection could impact the management of liver transplant recipients. Peripheral blood was collected following LT for discovery and validation. Blood gene profiling was paired with biopsies showing AR or ADNR as well as stable graft function samples.
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