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Columbia University Irving Medical Center via ScienceDaily
A genomic collision could explain why many kidney transplants fail, even when donors and recipients are thought to be well-matched, according to a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons. This genomic collision is a genetic incompatibility between kidney donor and recipient, causing the recipient to mount an immune attack against the donor protein.
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Associated Press via Omaha World-Herald
Organ transplant officials are rolling back a new nationwide policy over how to allocate scarce livers amid a legal fight in federal court, an attorney for the nonprofit that manages the U.S. transplant system said May 20.
The United Network for Organ Sharing was on track to reinstate its old policy by May 23, Sara Frey said during a hearing.
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Design News
Imagine a world where a patient in need of a liver transplant could immediately receive a bio-printed liver without having the agonizing wait of months or years for a donor organ to become available.
This is the promise of technology from a team at Rice University, which has developed a new technique for bioprinting tissues that reproduces—with the most complexity so far—vascular networks for the human body.
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Nephrology News & Issues via Healio
The National Kidney Foundation is building an interactive community platform to allow dialysis and transplant patients to communicate with others about kidney disease. The project is set to launch next year.
“For the first time, we will have a comprehensive collection of patient data which will enable us to better design patient education resources, more targeted care and more patient-centered clinical trials to discover new treatments for the disease,” Kerry Willis, PhD, chief scientific officer of the NKF, said. “There is no other kidney disease registry in the world that combines patient-entered data with data from electronic health records, and this pivotal combination will provide us with a 360° view of the patient we are working to help.”
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National Institute of Health
In this cohort study of 10,869 living kidney donors from the ImmPort open access data repository, 9,558 individuals' postdonation data were analyzed. Overall, 1,406 living donors (14.7 percent) had postdonation events; the four most common events were hypertension, diabetes, proteinuria, and postoperative ileus, and most events that occurred more than two years after transplant were unrelated to surgical complications, occurring up to 40 years later.
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Gastroenterology via Healio
Patients with NASH who underwent bariatric surgery were no more likely to undergo liver transplantation surgery than those without a history of bariatric surgery, according to a study presented at Digestive Disease Week.
“Obesity is directly linked with [the] development of NASH, which is one of the leading indications for liver transplantation,” Paul T. Kroner, MD, MSc, gastroenterology fellow at Mayo Clinic Florida, and colleagues wrote. “Bariatric surgery is a successful treatment option for obesity in NASH and may be performed in the pre-liver transplantation setting to improve transplant candidacy. However, the impact of previous bariatric surgery on immediate post-liver transplantation outcomes has not been studied.”
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American Journal of Transplantation via Wiley Online Library
Portal hyperperfusion and "dearterialization" of the liver remnant are the main pathogenic mechanisms for Small For Size syndrome. ALPPS induces rapid remnant hypertrophy. We hypothesized similar increase in portal pressure/flow into the future liver remnant in ALPPS and SFSS‐setting hepatectomies.
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The Journal of Heart and Lung Transplantation
Chronic lung allograft dysfunction is a major cause of post‒lung transplant mortality, with limited medical treatment options. In this study we assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD.
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