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The International Transplant Nurses Society (ITNS) 2020 Annual Meeting will be held online. Your registration fee includes access to all educational sessions (live and recorded), e-posters, and exhibits. Earn up to 30 hours of CE/CEPTC. Register by September 30 and save $100. Sign up today.
AST
The COVID-19 pandemic has created many questions about returning to school for pediatric solid organ transplant recipients and their families. While the risk of getting COVID-19 in school will never be zero when COVID-19 cases are present in a community, a team of pediatric transplant infectious diseases experts has provided information to help families make decisions with their transplant teams about school attendance for their child who has received a liver, lung, kidney, heart, or pancreas transplant. These recommendations were developed jointly by a number of medical organizations, including the AST, and are focused on K-12th grade.
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Healio
Donor-derived HIV superinfection “might not be a significant clinical concern” in transplants between people with HIV if the organ recipient is well monitored and virally suppressed on ART, researchers reported in The Lancet HIV.
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Nephrology Times
Following successful pilot trials of transplanting organs from hepatitis C virus viremic donors into HCV-negative recipients, there has been an expansion of the practice. Direct-acting antiviral therapies are costly, creating barriers to insurance coverage approvals, particularly in transplantation from HCV positive donors to HCV-negative recipients, due in part to off-label treatment of acute HCV following intentional HCV transmission.
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Hennepin Healthcare Research Institute via EurekAlert!
Transplant candidates face obstacles in finding a transplant program that transplants patients like them. A new online tool developed by researchers at Hennepin Healthcare Research Institute and the University of Minnesota is helping to remove those barriers.
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Veloxis Pharmaceuticals
Watch kidney transplant patients talk about their diagnoses and the importance of communication with their doctors and transplant teams. For these patients, switching therapies made sense.
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Journal of Shoulder and Elbow Surgery via MD Linx
Solid organ transplant patients undergoing shoulder arthroplasty were compared with a matched control group regarding the complications and functional outcomes. Retrospective review of the institution's database yielded data of 15 patients with previous SOT who underwent 19 shoulder arthroplasties and 34 patients undergoing 35 shoulder arthroplasties for the control group. Outcomes support the safety and effectiveness of performing shoulder arthroplasty in patients with previous SOT for degenerative shoulder disorders.
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Transplantation
Combined liver–kidney transplantation improves survival for liver transplant recipients with renal dysfunction; however, the tenuous perioperative hemodynamic and metabolic milieu in high-acuity CLKT recipients increases delayed graft function and kidney allograft failure. Researchers sought to analyze whether delayed KT through pumping would improve kidney outcomes following CLKT.
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Veloxis Pharmaceuticals
Over the long-term, graft survival may be impacted by factors such as declining adherence, which may be affected by complex dosing regimens and neurotoxicities. Studies show a direct correlation between rejection losses and nonadherence, which is also proven to increase over time. Review 2-year published data and see the results achieved at 2 years in de novo kidney transplant patients.
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American Journal of Transplantation
Transplant centers coordinate complex care in acute liver failure, for which liver transplantation can be lifesaving. Researchers studied associations between waitlist outcomes and center ALF waitlist volume and total LT volume in a retrospective cohort of 3,248 adults with ALF listed for LT at 92 centers nationally from 2002‐2019.
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Transplantation
Although short-term outcomes for liver transplantation have improved, patient and graft survival are limited by infection, cancer, and other complications of immunosuppression. Rapid induction of tolerance after liver transplantation would decrease these complications, improving survival and quality of life. Tolerance to kidneys, but not thoracic organs or islets, has been achieved in nonhuman primates and humans through the induction of transient donor chimerism. Since the liver is considered to be tolerogenic, researchers tested the hypothesis that the renal transplant transient chimerism protocol would induce liver tolerance.
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