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Join your transplant nursing community for the first ever virtual Annual Meeting, October 22-25, 2020. Your registration gives you access to all educational sessions, e-posters and virtual exhibits for one year! Hear from experts in the field such as: Jon Kobashigawa, MD, Mark Lockwood, PhD MSN RN and more! Sign-up by September 30 to save $100 on your registration fee. Learn more.
After viewing this recorded webinar you will learn best practices in: MSUD and the pathophysiology, current medical therapies for and complications of MSUD, and domino donation and its long-term outcomes for the recipient. The webinar is free for ITNS members, and $5.00 USD for nonmembers. Learn more.
AASLD
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been devastating to health care delivery in many parts of the U.S. and has had a significant impact on organ transplantation. With shelter-in-place orders, outpatient clinics transitioned to telemedicine, and the threat of hospitals being overrun with COVID-19 patients, liver transplant programs have been faced with the challenge of balancing patient and staff safety while operating in a resource limited environment.
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HealthDay News via Medical Xpress
Women are more likely than men to die waiting for a liver transplant, according to a study recently published in JAMA Surgery. Jayme E. Locke, M.D., from University of Alabama at Birmingham School of Medicine, and colleagues assessed adult liver-only transplant listings reported to the Organ Procurement and Transplantation Network from June 18, 2013, through March 1, 2018. Sex disparities in wait list mortality and deceased donor liver transplant were evaluated.
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Terasaki Institute for Biomedical Innovation via EurekAlert!
Engineering new tissues can be used to alleviate shortages of organs in transplantation, as well as to develop physiological models for drug discovery applications. One of the emerging approaches to building tissues is through 3D printing, where cells and materials can be combined to make inks that can generate tissue structures. One of the limitations for making new tissues is that they require oxygen to survive. This oxygen is delivered through blood vessels, which take a few days to develop in a transplanted tissue.
A collaborative team, which includes a group from the Terasaki Institute for Biomedical Innovation, has developed a bioink that offers a solution to this problem. This bioink can generate oxygen and deliver it to cells in 3D printed tissues to keep them alive before blood vessels penetrate the tissue. Therefore, when it is used in 3D bioprinting to construct tissue implants, the ability of cells to regenerate new tissue is greatly enhanced.
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BioEdge
The COVID-19 pandemic has put organ transplant programs around the world on hold. In the Indian state of Karnataka, there were no cadaver donation from March to August.
Transplant surgeons have complained that an estimated 2,000 people with kidney problems are on a waiting list.
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Veloxis Pharmaceuticals
Watch kidney transplant patients talk about their diagnoses and the importance of communication with their doctors and transplant teams. For these patients, switching therapies made sense.
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Cystic Fibrosis News Today
A series of new research projects will seek to better understand how the immune system responds to transplanted organs, including the lungs. The goal is to find ways to increase the viability of organs after transplant, which could improve care for conditions like cystic fibrosis.
The projects are being funded by a $7.7 million program grant from the National Institute of Allergy and Infectious Diseases that’s focused on lung transplant rejection, and a $2.6 million award from the National Heart, Lung, and Blood Institute, which is directed at heart transplant rejection. Both organizations are part of the National Institutes of Health.
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HCP Live
The incidence of active tuberculosis in patients following kidney transplants is significantly higher than the general population. While researchers in the past have described this as presenting in the first year following solid organ transplantation and is predominantly caused by disease reactivation.
However, diagnosing active tuberculosis can be challenging in patients in this population who may present with atypical presentations or extra-pulmonary infection.
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Veloxis Pharmaceuticals
There are many factors that may put a graft at risk, such as infections, nephrotoxicity, declining adherence, and inadequate immunosuppression. It can be difficult to achieve a balance between overimmunosuppression and underimmunosuppression in kidney transplant patients, putting patients at risk.
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American Journal of Transplantation
Body mass index is a known risk factor associated with kidney transplant outcomes and is incorporated for determining transplant candidate eligibility. However, BMI is a coarse health measure and risks associated with BMI may vary by patient characteristics.
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ScienceDirect
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells has not been previously described.
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