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The Organ Procurement and Transplantation Network (OPTN) currently have eight (8) initiatives available for public comment. The OPTN Public Comment period will end on October 2.
The initiatives and portal to submit feedback or suggestions can be found on the OPTN website.
In addition to the OPTN page that includes the public comment papers, UNOS published a new page about public comment last week that features a more plain-language presentation of proposals currently out for public comment and the process itself.
ITNS encourages you to participate in the public comment period and provide your perspective on this important proposed initiatives.
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Veloxis Pharmaceuticals
Follow the journeys of kidney transplant patients who transitioned to a different immunosuppression regimen. After talking with their doctors about their experiences with other options, they decided to make a switch.
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The Lancet
Low donor heart availability underscores the need to identify all potentially transplantable organs. We sought to determine whether pre-emptive administration of pangenotypic direct-acting antiviral therapy can safely prevent the development of chronic hepatitis C virus (HCV) infection in uninfected recipients of HCV-infected donor hearts.
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AJT
Although neutropenia is a common complication following lung transplantation, its relationship to recipient outcomes remains understudied. We evaluated a retrospective cohort of 228 adult lung transplant recipients between 2008 and 2013 to assess the association of neutropenia and Granulocyte Colony Stimulating Factor (GCSF) treatment with outcomes.
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Veloxis Pharmaceuticals
Explore this phase 3 randomized, double-blind, double-dummy, multicenter, multinational, non-inferiority trial published in the American Journal of Transplantation. The study examined treatment failures defined as BPAR, graft failure, death, and delayed graft function at 3 months and 12 months.
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Infectious Disease Advisor
Pneumococcal colonization rates are low in recipients of solid organ transplants, but most of the colonizing serotypes are not included in pneumococcal vaccines, according to study results published in BMC Infectious Diseases.
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American Journal of Transplantation
This study assessed the efficacy and safety of the anti-CD40 monoclonal antibody bleselumab (ASKP1240) in de novo kidney transplant recipients over 36 months post-transplant.
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JAMA
For-profit (vs nonprofit) dialysis facilities have historically had lower kidney transplantation rates, but it is unknown if the pattern holds for living donor and deceased donor kidney transplantation, varies by facility ownership, or has persisted over time in a nationally representative population.
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AASLD
A high proportion of patients develop chronic kidney disease after liver transplantation. We aimed to develop clinical/protein models to predict future GFR deterioration in this population. In independent multicenter discovery (CTOT14) and single center validation (BUMC) cohorts, we analyzed kidney injury proteins in serum/plasma samples at month 3 after liver transplant in recipients with preserved GFR who demonstrated subsequent GFR deterioration vs. preservation by year 1, and year 5 in the BUMC cohort.
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By Chelsea Adams
More than a dozen scientific research papers have been retracted amid suspicions the organs used in the studies came from executed Chinese prisoners. During August, the journals PLOS ONE and Transplantation retracted 15 studies after questions regarding the source of donated organs were posed. The studies were originally published between 2008 and 2014 and dealt with kidney and liver transplants. Two additional journals have also expressed concern regarding published studies.
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Wyss Institute for Biologically Inspired Engineering at Harvard via ScienceDaily
Artificially grown human organs are seen by many as the "holy grail" for resolving the organ shortage, and advances in 3D printing have led to a boom in using that technique to build living tissue constructs in the shape of human organs. However, all 3D-printed human tissues to date lack the cellular density and organ-level functions required for them to be used in organ repair and replacement.
Now, a new technique called SWIFT (sacrificial writing into functional tissue), created by researchers from Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences, overcomes that major hurdle by 3D printing vascular channels into living matrices composed of stem-cell-derived organ building blocks, yielding viable, organ-specific tissues with high cell density and function. The research is reported in Science Advances.
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