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Veloxis Pharmaceuticals
Follow the journeys of kidney transplant patients who transitioned to a different immunosuppression regimen. After talking with their doctors about their experiences with other options, they decided to make a switch.
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The Philadelphia Inquirer
A national rule meant to increase the number of heart transplants for the sickest children has not resulted in improved survival, a new study has found.
The March 2016 change in how organs are allocated gave first priority to children born with significant heart defects, such as when most of the left side is missing. Those with a kind of pumping deficiency called cardiomyopathy, on the other hand, were in most cases given lower priority — on the theory that their cases were more manageable with medication. But since the change took effect, physicians have been more likely to seek special exceptions for certain cardiomyopathy patients, bumping them up to top-priority status and partly undoing the intent of the policy, the authors wrote in the American Journal of Transplantation.
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By Chelsea Adams
The donor-priority rule was developed as a potential way to encourage organ donor registrations. If a person signs up to be an organ donor, the potential donor will receive a higher priority on the transplant list if he or she ever needs an organ transplant. However, this arrangement brings about an unintended consequence. People who are at risk of needing an organ transplant are more likely to register as organ donors. And generally speaking, people who need organ transplants are sick. New research published in the journal Management Science pinpoints a potential solution.
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American Journal of Transplantation
Allergy transfer upon solid organ transplantation has been reported in the literature, although only few data are available as to the frequency, significance and management of these cases. Based on a review of 577 consecutive deceased donors from the Swisstransplant Donor‐Registry, three cases (0.5%) of fatal anaphylaxis were identified, two because of peanut and one of wasp allergy.
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Veloxis Pharmaceuticals
There are many factors that may put a graft at risk, such as infections, nephrotoxicity, declining adherence, and inadequate immunosuppression. It can be difficult to achieve a balance between overimmunosuppression and underimmunosuppression in kidney transplant patients, putting patients at risk.
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Patch
A medical "first" for liver transplants took place in Newark on Sept. 23. A liver preserved by portable hypothermic machine perfusion was successfully transplanted at University Hospital, breaking new ground in New Jersey, according to the medical center.
The new technology helps increase the time surgeons have in determining an organ's health and performance before a transplant.
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CORDIS via Medical Xpress
So far, no algorithm predicting long-term graft survival in kidney transplantation has been validated in different countries, populations and clinical scenarios, nor in the setting of randomized controlled trials.
Researchers from the Paris Transplant Group, led by Professor Alexandre Loupy, looked at long-term patient data, and considered a wide variety of patient, donor and graft parameters. They hypothesized that combining all these data into one prediction system with the use of artificial intelligence could lead to a robust integrative tool.
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Clinical Transplantation
Several studies in solid organ transplantation have shown a correlation between donor and recipient sex mismatch and risk of graft loss. In this study, researchers aimed to analyze the impact of donor and recipient sex matching on patient and pancreas graft survival in a large single center cohort.
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Journal of Heart and Lung Transplantation
Current ex vivo lung perfusion protocols aim to achieve perfusion flows of 40 percent of cardiac output or more. Researchers hypothesized that a lower target flow rate during EVLP would improve graft function and decrease inflammation of donation after circulatory death lungs.
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Infectious Disease Advisor
When treating hepatitis E virus, the addition of sofosbuvir to a ribavirin-based regimen in solid organ transplant recipients does not result in sustained virologic response, according to a study published in Open Forum Infectious Diseases.
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