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SLAS
Could hijacking one of the body's own systems be the key to finding new targets for hard-to-treat diseases? Dane Mohl, Ph.D., scientist at Amgen (Thousand Oaks, CA, USA), believes it may be. In this newly published article and a sneak peek at his SLAS2019 presentation, Mohl gives readers a glimpse of what led to his research on the use of the ubiquitin proteasome pathway to target proteins whose functions have expired and are no longer needed. "Letting genetics guide our choices for treating disease means we have to use whatever modalities are available," Mohl says. "We have to be more creative and that means we need a larger tool box to get to those new targets."
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SLAS
SLAS is pleased to announce the appointment of three new members of the 2019 Board of Directors. Michelle Arkin, Ph.D., Sammy Datwani, Ph.D., and Hansjoerg Haas, Ph.D., each begin their three-year terms at SLAS2019, Feb. 2-6 in Washington, DC. Arkin, Datwani, and Haas will replace outgoing members Sabeth Verpoorte, Ian Shuttler and Peter Grandsard, who will be completing their terms.
MEET THE NEW MEMBERS
SLAS
Book your SLAS2019 hotel room by Jan. 3 to take advantage of special discounted pricing and benefits of staying at the Marriott Marquis and Renaissance Washington, DC Downtown hotels. Reservations made AFTER Jan. 3 are not guaranteed a spot in the SLAS2019 block or the special room rate. In addition, the Tuesday morning FUNd Run leaves from the Marriott and Tuesday evening shuttle buses to the Smithsonian leave from the Convention Center. After a long day of walking the Exhibition and networking with colleagues, you'll want to be just steps from your hotel. SECURE MY ROOM
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SLAS
Join the National Center for Advancing Translational Sciences (NCATS) for its two-day The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium.
Sessions will take an in-depth look at the challenges and opportunities of the discovery and development process for addiction- and pain-related medications in the pre-competitive preclinical stage, including a focus on current successes and failures and what's next in pain and addiction therapeutic discovery. The symposium will take place Feb. 7-8 at the National Institute of Health Natcher Auditorium in Bethesda, MD, just after the conclusion of SLAS2019. FULL DETAILS
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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SLAS
Plan now to submit your SLAS Discovery manuscript proposals (abstracts) on topics related to:
- Advances in Cellular Target Engagement and Target Deconvolution for publication in a 2020 special issue. Guest Editors Martin Main, Ph.D., (Medicines Discovery Catapult, Alderley Edge, UK) and Andrew Zhang, Ph.D., (AstraZeneca, Boston, MA, USA) invite manuscript proposals related to all methods for monitoring compound-target engagement in cells and for deconvoluting the molecular target of biologically active compounds. Manuscript proposals are due March 1, 2019. Invited submissions will be due July 1, 2019.
- Membrane Proteins: New Approaches to Probes, Technologies and Drug Design for publication in a 2019 special issue. Guest Editors Veli-Pekka Jaakola, Ph.D. (NIBR, Switzerland) and Mariafrancesca Scalise, Ph.D. (University of Calabria, Italy) invite manuscript proposals related to developments in membrane protein biology, as well as advances in X-ray crystallography, electron microscopy, assay technologies, expression and purification methods that enable the study of membrane protein targets.
Manuscript proposals are still being accepted. Invited submissions will be due March 1, 2019.
FULL SUBMISSION DETAILS
(SLAS Discovery is formerly known as the Journal of Biomolecular Screening.)
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Explore the best combination of kits and instruments to ensure gentle and fast isolation of primary cells for your drug discovery and in vitro assays. Curious? Watch our video on high-throughput cell isolation using the MultiMACS™ X Cell Separator for maximum efficiency and reproducibility.
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SLAS
SLAS Technology guest editors are currently seeking manuscript proposals (abstracts) for two new special issues:
- Flexible Analytical Devices for Point-of-Care Testing for publication in 2020. Guest editors Hideaki Tsutsui, Ph.D. (University of California, Riverside, USA) and Peter B. Lillehoj, Ph.D. (Michigan State University, USA) invite manuscript proposals related to technologies pertaining to flexible analytical devices for point-of-care testing. Abstracts are due March 1, 2019. Invited submissions will be due July 1, 2019.
- Carbohydrate Structure Analysis: Methods and Applications for publication in a 2020 special issue. Guest Editors Parastoo Azadi, Ph.D. and Christian Heiss, Ph.D., of the Complex Carbohydrate Research Center at the University of Georgia (USA) invite manuscript proposals related to new developments in carbohydrate structure analysis as well as applications of carbohydrate characterization.
Abstracts are due May 1, 2019. Invited submissions will be due Aug. 10, 2019.
FULL SUBMISSION DETAILS
(SLAS Technology is formerly known as the Journal of Laboratory Automation.)
slas
SLAS2019 International Conference and Exhibition
Feb. 2-6, 2019
Washington, DC, USA
Thursday, Jan. 3, 2019: Deadline for conference hotels discount (reservations made after this date will receive the group rate based only on individual hotel availability)
Monday, Jan. 21, 2019: Final Poster submission deadline
Sponsorship opportunities available!
SLAS Journals Special Issues Call for Papers
SLAS Discovery: Advances in Cellular Target Engagement and Target Deconvolution
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Flexible Analytical Devices for Point-of-Care Testing
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1, 2019: Proposals due
Aug. 10, 2019: Invited submissions due
Save These 2019 Dates!
SLAS 2019 European Sample Management Symposium
March 11-12, 2019
Berlin, Germany
January 28, 2019: Early Bird Registration Discount Ends
SLAS Europe 2019 Conference and Exhibition
June 26-28, 2019
Barcelona, Spain
February 11, 2019: Super Early Bird Registration Discount Ends
February 18, 2019: Podium abstracts due
Exhibit and sponsorship opportunities available!
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Science Daily
In a recent publication in Science, researchers at the University of Paderborn and the Fritz Haber Institute Berlin demonstrated their ability to observe electrons' movements during a chemical reaction. Researchers have long studied the atomic-scale processes that govern chemical reactions, but were never before able to observe electron motions as they happened.
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Journal of the American Chemical Society
We report a new strategy of controlling catalytic activity and selectivity of Cu nanoparticles (NPs) for the ammonia borane initiated hydrogenation reaction. Cu NPs are active and selective for chemoselective reduction of nitrostyrene to vinylaniline under ambient conditions. Their activity, selectivity, and more importantly, stability are greatly enhanced by their anchoring on WO2.72 nanorods, providing a room-temperature full conversion of nitrostyrene selectively to vinylaniline (>99% yield).
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Genetic Engineering & Biotechnology News
Good things often come in small packages, especially if they are tidily wrapped. Such is the case with our DNA, which in our vigorous youth is carefully tucked into our cells. Unfortunately, as we age, our DNA is often kept less neatly, as simple blood draws reveal. In blood, cell-free DNA (cfDNA) — that is, DNA released into the circulation by stressed or degraded cells — preserves the state of DNA packaging, providing a biomarker of biological age.
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Phys.org
By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers have unlocked several large gene clusters for new natural products, according to a new study.
Since many antibiotics, anti-cancer agents and other drugs have been derived from genes readily expressed in Streptomyces, the researchers hope that unsilencing genes that have not previously been expressed in the lab will yield additional candidates in the search for new antimicrobial drugs.
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Chemical & Engineering News
Tropane alkaloids, a broad class of natural products from plants, have been used as medicines for more than a century. Tropinone, the simplest tropane alkaloid, is a key intermediate in the synthesis of many others. It was first chemically synthesized in 1901, but the enzymes plants use to make it have remained a mystery — one that has now been solved.
Researchers have now identified two genes in Atropa belladonna (deadly nightshade) that code for enzymes that make tropinone.
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Laboratory Equipment
Mammalian embryos are unlike those of any other organism as they must grow within the mother's body. While other animal embryos grow outside the mother, their embryonic cells can get right to work accepting assignments, such as head, tail or vital organ. By contrast, mammalian embryos must first choose between forming the placenta or creating the baby.
New research at Michigan State University and published in the journal eLife has pinpointed two proteins that are the keys to this decision making.
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Lab Manager
For decades, chemists have aspired to do carefully controlled chemistry on carbon-hydrogen bonds. The challenge is staggering. It requires the power of a miniature wrecking ball to break these extremely strong bonds, combined with the finesse of microscopic tweezers to single out specific C-H bonds among the many crowded onto a molecule.
The journal Nature published a method that combines both these factors to make an inert C-H bond reactive — effectively turning chemical "trash" to "treasure."
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Research Analyst I
Vanderbilt Health
US - TN – Nashville
Research Associate II - Pathology - Dr. Stehlik
Cedars-Sinai
US - CA – Los Angeles
Medical Laboratory Scientist (MLS)
Fairbanks Memorial Hospital
US – AK – Fairbanks
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