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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 3, 2018

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Meet the 2018 SLAS Innovation Award Finalists
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Ten podium presenters will vie for the $10,000 SLAS Innovation Award cash prize at SLAS2018. Hailing from academia, industry and government and selected by a panel of judges based on the potential impact of the innovation, originality/creativity and quality of science represented in their work are:

Santiago Costantino, Ph.D. (University of Montreal, Montreal, Quebec)
Dennis Eastburn, Ph.D. (Mission Bio Inc., South San Francisco, CA)
Olivier Frey, Ph.D. (InSphero AG, Basel, Switzerland)
Rajarshi Guha, Ph.D. (National Institutes of Health, Rockville, MD)
Shane Horman, Ph.D. (Genomics Institute of the Novartis Research Foundation, San Diego, CA)
Paul Ju Sung Hung, Ph.D. (COMBiNATi Inc., Palo Alto, CA)
Transon V. Nguyen (Notable Labs, San Francisco, CA)
Amy Rowat, Ph.D. (University of California, Los Angeles)
Kevin Tsia, Ph.D. (The University of Hong Kong, Hong Kong)
Julea Vlassakis (University of California, Berkeley, Berkeley, CA)

Details on each finalist, including their presentation abstracts and titles, can be viewed on the SLAS2018 Event Scheduler. The final judging takes place at SLAS2018, Feb. 3-7 in San Diego, CA. Pictured here is the 2017 SLAS Innovation Award winner Elodie Sollier-Christen.
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New and FREE at SLAS Discovery: A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase
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A newly designed biochemical assay to identify antagonist against aldolase A (ALDOA) appears in the pages of the January 2018 issue of SLAS Discovery (Advancing Life Sciences R&D). In an original research report, Eun Jeong Cho et al. (The University of Texas at Austin) introduce an assay that is rapid, sensitive, inexpensive and high-throughput screening (HTS)-friendly. The authors demonstrate how to transform and integrate a traditional aldolase assay to an HTS-friendly platform by taking advantage of a commercially available nicotinamide adenine dinucleotide (NADH) detection system with enhanced sensitivity, reduced reagent requirements and reduced compound interference.

This adaptation and optimization of a readily available assay kit to an HTS protocol represents a cost- and labor-efficient solution, because de novo assay development can require several months to years. In addition, the universal characteristics of this newly created assay platform highlight its instant accommodation to the analysis of many NADH-dependent enzymes and to other high-throughput applications.
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IMPORTANT NOTICE: Last Call for Hotel Group Rates at SLAS2018
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The official SLAS2018 hotels, the Marriott Marquis San Diego Marina and Hilton San Diego Bayfront, are SOLD OUT on Feb. 5 and 6. SLAS has added the Hilton San Diego Gaslamp Quarter to the list of official SLAS2018 hotels and extended the group rate deadline (for this hotel only) to Friday, Jan. 12.

Located near the San Diego Convention Center, Hilton San Diego Gaslamp Quarter offers convenient locations and exclusive perks to those who reserve rooms through official booking channels. Be aware of bogus reservation scams and secure your reservations, discount rates and special amenities by booking through the SLAS2018 links.
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SLAS in the News: Forbes Article Addresses Lab Innovations
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According to a Dec. 21 article at Forbes online, scientific progress is moving "from white coats and pipettes to laptops and lattes," as research unfolds outside the walls of the lab. Writer Simon Smith, chief growth officer at BenchSci, describes how the use of lab automation, artificial intelligence, robotics, internet-of-things technologies and cloud computing are changing how scientists work. In composing the article, Smith interviewed SLAS Director of Education Steve Hamilton and SLAS member Alex Godfrey, a retired research advisor who worked on automation projects at Eli Lilly, among others, for "In The Lab Of The Future, Robots Run Experiments While Scientists Sleep."

Smith's article captures the upside of automation, from improved speed, accuracy and reproducibility, to the challenges of a changing lab, which might include job cuts, decreased lab time and increased bureaucratic tasks for scientists. Look for it online.
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Publishing Questions Answered at SLAS2018
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Sign up now for a limited number of one-on-one personal consultations with the editors-in-chief of SLAS Discovery (Advancing Life Sciences R&D) and SLAS Technology (Translating Life Sciences Innovation) at SLAS2018. Appointments are being accepted on a first come, first served basis — contact nhallock@slas.org. This great opportunity gives prospective authors personal time to discuss their work, ask about publication options and learn more about how the SLAS journals can help researchers make a bigger splash in life sciences.

Plus, in the SLAS Journals Information Station (Aisle 200 of the SLAS2018 Exhibition), SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D. (National University of Singapore) will be available to greet visitors on Monday, Feb. 5, from 12:30-1 p.m.; and SLAS Discovery Editor-in-Chief Robert M. Campbell, Ph.D. (Eli Lilly, Indianapolis, IN) will be available on Tuesday, Feb. 6, from 12:30-1 p.m. Visitors who volunteer to serve as reviewers and opt-in to receive SAGE Track news may enter to win a video drone ($500 value).
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Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report, learn how viDA Therapeutics streamlined their processes and improved collaboration.


Need Some FREE Career Advice?
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Curious about pursuing a new professional opportunity in life sciences discovery or technology? Wondering about that next step in your career advancement? Reserve your one-on-one mentoring and career counseling session with an industry expert hosted by the SLAS Mentor Program at SLAS2018.

As part of SLAS Career Connections, these 45-minute mentoring sessions will be held at SLAS2018 on Monday, Feb. 5 and Tuesday, Feb. 6 in the morning and afternoon. Match your interests and goals to the professional backgrounds of 15 established life sciences professionals from industry, academia and government who will be available to offer strategic advice. Representing such diverse areas as early discovery in vitro pharmacology, compound and materials management, pre-clinical innovation, automation design and engineering and high-throughput screening (HTS), as well as target identification and lead optimization, these mentors will share their wisdom with career planners who sign up for a session.
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CRISPR Proves Promising for Treating ALS in Mice
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CRISPR-Cas9 gene editing can extend survival in a mouse model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, according to a study published in Science Advances. "The treatment did not make the ALS mice normal and it is not yet a cure," study coauthor David Schaffer, a professor of chemical and biomolecular engineering at the University of California, Berkeley, says in a press release. "But based upon what I think is a really strong proof of concept, CRISPR-Cas9 could be a therapeutic molecule for ALS." More




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New Structure of Key Protein Holds Clues for Better Drug Design
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Scientists at The Scripps Research Institute (TSRI) have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. The protein, called the A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals. More


2017 Breakthrough of the Year: Cosmic Convergence
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On Aug. 17, scientists around the world witnessed something never seen before: 130 million light-years away, two neutron stars spiraled into each other in a spectacular explosion that was studied by observatories ranging from gamma ray detectors to radio telescopes. The blast confirmed several key astrophysical models, revealed a birthplace of many heavy elements, and tested the general theory of relativity as never before. That first observation of a neutron-star merger, and the scientific bounty it revealed, is Science's 2017 Breakthrough of the Year. More




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SLAS2018 Tutorial Closes The Screening Loop

Titian, HighRes and Genedata's SLAS2018 tutorial 'Partnering to Close the Screening Loop' demonstrates a seamless workflow to support the iterative drug discovery life cycle of designing, planning, testing and analyzing. The approach effortlessly moves information to where it needs to be.

Register to receive this tutorial recording.


CAR-Engineered Blood Stem Cells Offer New Hope for Long-Term HIV Gene Therapy
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers in the U.S. have created chimeric antigen receptor (CAR)-engineered hematopoietic stem/progenitor cells (HSPCs), which successfully engrafted in pigtail macaques infected with simian human immunodeficiency virus (SHIV) and generated virus-targeting cytotoxic T cells that destroyed infected cells. Reporting in PLOS Pathogens, the researchers say that that the CAR-engineered HSPCs persisted in the animals for more than two years, suggesting that their approach could successfully be used to treat infections such as HIV that can re-emerge after many years of suppression or dormancy. More


Chemists Provide Theoretical Interpretation to Understand Chemical Reactions
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In a lot of ways, understanding quantum mechanical equations in an effort to predict what will happen between reactants such as atoms and molecules resulting in complex phenomena in chemistry can be exhausting, and mind boggling to many. Yet, without the theoretical insights, experimental chemists would largely be unable to understand what they are observing. Researchers at the University of New Mexico have been working with experimentalists to help them gain an understanding by providing theoretical interpretations of experimental observations. More




Synthesis, Structures, and Properties of Hexapole Helicenes: Assembling Six [5]Helicene Substructures into Highly Twisted Aromatic Systems
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Hexapole helicenes 1, which contain six [5]helicene substructures, were synthesized by Pd-catalyzed [2+2+2]cycloadditions of aryne precursor 6. Among the possible 20 stereoisomers, which include ten pairs of enantiomers, HH-1 was obtained selectively. Density functional theory (DFT) calculations identified HH-1 as the second most stable isomer that quantitatively isomerizes under thermal conditions into the most stable isomer (HH-2). More


A Novel Way to Synthesize Antioxidant Substances
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Scientists from Tomsk Polytechnic University together with their colleagues from USA and Japan have proposed a novel way to address the most important and fundamental challenge of organic chemistry, i.e. breaking a bond between carbon and hydrogen atoms to form new organic substances. They were the first to carry out "breaking" in water thanks to especially synthesized substances called arylbenziodoxaboroles. As a result, the scientists synthesized a number of novel phenolic substances that possess high biological and antioxidant activity. In the future, they can be used for drug creation. More


First Gene Therapy for Genetic Disease Approved
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A shot of DNA-filled viruses injected directly into the eye is now the first gene therapy approved in the U.S. to treat a genetic disease. The approval is a landmark moment for a field riddled with ups and downs since the first gene therapy trial began nearly three decades ago. The therapy, called Luxturna, treats a form of inherited blindness, and was developed by Philadelphia-based Spark Therapeutics. Luxturna got an earlier-than-expected thumbs up from the U.S. Food & Drug Administration. More


Automated ChIP Assay
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Porvair Sciences and Suzhou Tianlong Bio Technology Co Ltd (China) are developing an automated ChIP assay that enables users to perform chromatin isolation straight through to multiplex PCR, completely hands-free. Researchers and diagnostic laboratories will be able to simultaneously analyze multiple epigenetic marks using less material and obtain better quantitative analyses. Diagnostic multiplex arrays are currently available for a number of cancer disease states, but its application in breast and ovarian cancers is non-existent, which greatly impacts the development of novel therapeutics. More


Career


Assistant/Associate Professor in Bioengineering
University of Florida Whitney Laboratory for Marine Bioscience
US - FLA - St. Augustine

Assistant/Associate Professor in Neuroscience
University of Florida Whitney Laboratory for Marine Bioscience
US - FLA - St. Augustine

Nance K. Dicciani Endowed Professor of Chemical Engineering
Villanova University
US - PA – Villanova

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