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SLAS.org    SLAS2012   Moving? New job? Let SLAS know.    Jan. 4, 2012



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SLAS reviews epigenetics
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Read the new SLAS Electronic Laboratory Neighborhood state-of-the-science report on this booming area of drug discovery. Then, dig deeper into the topic in the JBS special issue on epigenetic-targeted drug discovery. And coming soon: a podcast on the topic by The Lab Man. More

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SLAS speaker wins Taylor Prize
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SLAS 2011 Stem Cell Global Symposium speaker Rudolph Jaenisch, The Whitehead Institute, presents "Stem Cells and the Promise for Personalized Medicine" at the Robarts Research Institute's Taylor Symposium. Jaenisch is the winner of the 2011 Taylor Prize. More



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4 weeks until SLAS2012!
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The calendar has turned to the new year, and SLAS2012, Feb. 4-8 in San Diego, is just about here! Excitement is high for this SLAS First Annual Conference and Exhibition — engage in the biggest and boldest event of the year for those shaping the field of laboratory science and technology. Jan. 19 is the final day to submit poster abstracts. More

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Bradley wins trip to SLAS2012
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Congratulations to Jenifer Bradley of Pfizer, who wins a trip to SLAS2012 in San Diego (including registration, airfare and hotel). Bradley's name was picked randomly from those completing the SLAS membership survey by Dec. 15. More

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Welcome new corporate member Tecan
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Tecan, also an SLAS2012 exhibitor and diamond sponsor, joins a distinguished list of businesses and organizations participating in SLAS as corporate members. More
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Genetic predisposition to disease common in 2 supercentenarians
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The first-ever published whole-genome sequences of not just one, but two supercentenarians, aged more than 114 years, reveal that both unusual and common genetic phenomena contribute to the genetic background of extreme human longevity. Data from the study will be available to researchers around the world at the NIH data repository. More

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Genetic analysis revises treatment recommendations related to thyroid cancer
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Cleveland Clinic researchers have discovered three genes that increase the risk of thyroid cancer, which has the largest incidence increase in cancers among both men and women. Research led by Charis Eng, M.D., Ph.D., included nearly 3,000 patients with Cowden syndrome or CS-like disease, which is related to an increased risk of breast and thyroid cancer. More

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A yeast functional screen predicts new candidate ALS disease genes
National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Amyotrophic lateral sclerosis is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-like domains, cause some forms of ALS. There are at least 213 human proteins harboring RNA recognition motifs, including FUS and TDP-43, raising the possibility that additional RNA-binding proteins might contribute to ALS pathogenesis. More

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Conductance-based chemical sensing in metallic nanowires and metal-semiconductor nanostructures
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Conductance-based chemical sensing in metal-semiconductor nanostructures and all-metal nanowires of atomic dimensions is garnering increased interest. Adsorbed gas molecules can migrate to a metal-semiconductor junction, thereby shifting the magnitude of the Schottky barrier and altering electrical impedance, whereas atomic scale metal junctions can sensitively report the presence of adsorbates through their impact on ballistic electron transport. More

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Targeted therapy extends progression-free survival of patients with advanced ovarian cancer
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Targeted drugs, which block or disrupt particular molecules involved in the growth of tumors, have been shown to be effective treatments against many types of cancer. A new phase 3 clinical trial conducted by the Gynecologic Oncology Group showed that a targeted therapy called bevacizumab effectively delayed the progression of advanced ovarian cancer. More

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hERGCentral: A large database to store, retrieve and analyze compound-human Ether-a-go-go related gene channel interactions
ASSAY and Drug Development Technologies    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The unintended and often promiscous inhibition of the cardiac human Ether-a-go-go related gene potassium channel is a common cause for either delay or removal of therapeutic compounds from development and withdrawal of marketed drugs. The clinical manifestion is prolongation of the duration between QRS complex and T-wave measured by surface electrocardiogram — hence Long QT Syndrome. More



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6 ways we kill innovation without even trying
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Why do some great ideas fail and others succeed? The innovations pioneered by someone like Apple CEO Steve Jobs may have less to do with "out of the box" creativity than with mastering — and overcoming — a set of fundamental constraints that span everything from technology to society to group dynamics. More

Method of the year for 2011
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Perhaps the most reliable way to learn about the function of a gene or protein is to specifically perturb it and monitor what happens. This reverse genetic approach is routinely applied in many species, but, with a few exceptions, it is challenging or even impossible to make targeted changes at endogenous genomic loci, arguably the most elegant method of genetic perturbation. More



Powerful painkiller worries abuse experts
Drug Discovery & Development    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Drug companies are working to develop a pure, more powerful version of the nation's second most-abused medicine, which has addiction experts worried that it could spur a new wave of abuse. The pills contain the highly addictive painkiller hydrocodone, packing up to 10 times the amount of the drug as existing medications such as Vicodin. More

New year brings new attacks on evolution in schools
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The new year is bringing new controversy over teaching evolution in public schools, with two bills in New Hampshire seeking to require teachers to teach the theory more as philosophy than science. Meanwhile, an Indiana state senator has introduced a bill that would allow school boards to require the teaching of creationism. More


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Career

Lead Software Development Engineer
Pointwise, Inc.
USA – TX – Fort Worth

Tenure Track Position Environmental Technology Management — Environmental Chemistry
Arizona State University Polytechnic
USA – AZ – Mesa

Staff Packaging Engineer
Edwards Lifesciences
USA – CA – Irvine

More jobs at SLAS Career Connections


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Precision System Science Latest Innovations

Announcing geneLead® Fully Automated Real Time PCR system and Next Gen Sequencing size selection and chemical shearing reagents on the 8G Compact. www.pssbio.com




Expert Advice/Stimulating Conversation

Discussions and musings focused on the engaging field of laboratory science and technology.



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SLAS Point-to-Point
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