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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 4, 2017

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SLAS2017 Hotel Discount Deadline is Jan. 5 and Rooms are Filling Quickly
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SLAS has negotiated discounted rates for SLAS2017 participants at premier hotels surrounding the Walter E. Washington Convention Center, including the recently added Grand Hyatt Washington Hotel. The deadline for securing these discounts is tomorrow, Jan. 5.

Availability changes regularly and the most up-to-date information can be accessed by using the individual hotel links on the SLAS2017 website. Staying at an official SLAS2017 hotel and booking through approved channels keeps you at the center of SLAS activity and offers special perks like free internet and fitness center access.
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Responsive Design: The 2016 SLAS Annual Report
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SLAS is the life sciences discovery and technology community's destination for information, ideas, answers and inspiration.

Take a look back at an exciting year that began with the record-setting SLAS2016 in San Diego and continued with advances in the SLAS European community and the introduction of new journal names, the SLAS Fellow Member category, awarding of the first SLAS Graduate Education Fellowship Grant and more.
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A Perspective on the Kinetics of Covalent and Irreversible Inhibition
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A new perspective paper in the January 2017 issue of SLAS Discovery (formerly JBS) offers a contemporary perspective on the importance of kinetics in the evaluation of covalent and irreversible drugs.

The report demonstrates how covalent kinetics, as defined by the kinact/KI rate constant, can impact all stages of drug discovery ranging from biochemical screening to estimation of an in vivo dose. Non-members may read this paper for free for a limited time.
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SLAS2017 Poster Abstract Submissions Welcome until Jan. 23
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Delivering a poster presentation at SLAS2017 offers significant visibility to authors and their organizations. Submit your poster abstract by Jan. 23 for the opportunity to present your work and receive thoughtful input from an extremely knowledgeable, friendly and collaborative community.

Selected posters are available for viewing throughout SLAS2017 Exhibition hours, and specific times are scheduled where authors are present to discuss their work. All presenters must be registered as full conference attendees. After the conference, posters will be accessible online in the SLAS2017 Poster Gallery.
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2017 SLAS Europe Compound Management Conference
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"Breaking Down Walls — Uniting Sample Management Communities to Advance Scientific Innovation," March 14-15, 2017, provides compound management and lead discovery professionals at all levels fresh perspectives and innovative solutions.

Conference Chair Clive Green, director and head of sample management at AstraZeneca, UK, and his committee invite you to explore how to provide the right compound at the right time and in the best possible quality to allow the generation of meaningful screening, pharmacological, toxicological or ADME profiling data. Conference registration is open, and scientific poster abstracts can be submitted until Feb. 1.
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SLAS2017 Short Course Spotlight: Data Analytic Concepts for High-Throughput Screening and Biomarker Applications
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Explore data analytic concepts such as the minimum significant ratio and error-rate estimation for high-throughput screening, false discovery rate, multivariate predictive modeling process and performance evaluation for high-dimensional -omics data, as well as statistical considerations for biomarker assay evaluations.

Course instructor is Viswanath Devanarayan, global head of exploratory statistics and a senior research fellow at AbbVie. Data Analytic Concepts for High-Throughput Screening and Biomarker Applications is one of 20 Short Courses to be held at SLAS2017.
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UN Rejects Calls for Moratorium on Gene Drive Research
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The United Nations biodiversity meeting, held in Mexico last month, could have ended poorly for scientists working on gene drives, genetic elements that can perpetuate specific mutations and may help cull dangerous mosquito populations. But in spite of environmental activists pushing the UN to ban gene drives, citing the risk of accidental release, the UN's final agreement — penned Dec. 16 — merely urged caution in testing gene drives, Nature reported. More


Expanding CRISPR Toolkit May Render Patent Fight Moot
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
University of California, Berkeley, scientists have found entirely new classes of Cas proteins, the enzymes responsible for snipping DNA in the CRISPR gene-editing system. The discovery expands the ever-growing CRISPR toolbox and creates a new wrinkle in the ongoing patent dispute between Berkeley and the Broad Institute of Harvard University and MIT over the gene-editing technology. More


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Mechanism for Si-Si Bond Rupture in Single Molecule Junctions
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The stability of chemical bonds can be studied experimentally by rupturing single molecule junctions under applied voltage. Here, we compare voltage-induced bond rupture in two Si-Si backbones: one has no alternate conductive pathway whereas the other contains an additional naphthyl pathway in parallel to the Si-Si bond. We show that in contrast to the first system, the second can conduct through the naphthyl group when the Si-Si bond is ruptured using an applied voltage. More


Know Thy Enemy: Kill MRSA With Tailored Chemistry
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
University of Connecticut medicinal chemists have developed experimental antibiotics that kill MRSA, a common and often deadly bacteria that causes skin, lung, and heart infections. The success is due to their strategy, which found a weakness and exploited it in a way the bacteria should have trouble countering, the researchers report in the Dec. 22 issue of Cell Chemical Biology. Cases of MRSA (Methicillin-Resistant Staphylococcus aureus) are on the rise and increasingly resistant to common antibiotics. More


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Off Switch Found for Common Version of the CRISPR-Cas9 System
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Shouldn't a better mousetrap have a better off switch? That's the question posed by researchers at the University of California, San Francisco (UCSF), who are working to make molecular biology's better mousetrap — the CRISPR-Cas9 gene-editing system — even better. Although CRISPR-Cas9 is a tremendously exciting tool, one that can target selected genomic sites, it isn't exactly glitch-free. More


Ancient DNA Can Both Diminish and Defend Modern Minds
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
You've likely heard about being in the right place at the wrong time, but what about having the right genes in the wrong environment? In other words, could a genetic mutation (or allele) that puts populations at risk for illnesses in one environmental setting manifest itself in positive ways in a different setting? That's the question behind a recent paper published in The FASEB Journal by several researchers. More




Visualizing Gene Expression with MRI
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Genes tell cells what to do — for example, when to repair DNA mistakes or when to die — and can be turned on or off like a light switch. Knowing which genes are switched on, or expressed, is important for the treatment and monitoring of disease. Now, for the first time, Caltech scientists have developed a simple way to visualize gene expression in cells deep inside the body using a common imaging technology. More


New Class of Hydrogen Sulfide Donor Molecules
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Molecules with the potential to deliver healing power to stressed cells — such as those involved in heart attacks — have been created by University of Oregon researchers. The research — done at a cellular level in the lab and far from medical reality — involves the design of organic molecules that break down to release hydrogen sulfide when triggered by specific conditions such as increased oxidative stress. More


Career


Postdoctoral Fellow, Multi-Photo Imaging of Neocortex
University of South Carolina
US – SC – Charleston

Staff Scientist
National Institute of Neurological Disorders and Stroke
US – MD – Bethesda

Postdoctoral Research Fellow – Cell Biology/Mechanotransduction
NIH National Institute on Deafness and Other Communication Disorders
US – MD – Bethesda

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