This message contains images. If you don't see images, click here to view. Advertise in this news brief. Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 06, 2016 SLAS.org    SLAS2016    Moving? New job? Let SLAS know.       Advertisement Advertisement Advertisement Advertisement Advertisement Advertisement   Advertisement A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay (CiPA) Paradigm SLAS    Share    A new review article tops the table of contents in the January 2016 issue of JBS. It discusses a novel public-private initiative that supports proarrhythmia risk assessment of candidate drugs early in the drug discovery and development continuum. According to lead author Bernard Fermini, Ph.D., of the Department of Global Safety Pharmacology at Pfizer (Groton, CT) and colleagues from the Ion Channel Working Group (composed of members from pharma industry, universities and contract research organizations), the current approach suffers from acknowledged limitations. While it provides a regulatory framework for the detection of delayed cardiac repolarization by focusing on the inhibition of a single, essential, cardiac ion channel (hERG), and in vivo assessment of QT prolongation, it doesn't assess the endpoint of clinical concern (namely ventricular arrhythmias), and needs revision. More Advertisement Last Chance: Submit SLAS2016 Poster Abstracts by Jan. 11 SLAS    Share    There are just a few days left to submit poster abstracts to share your recent achievements on the SLAS2016 global stage, Jan. 23-27, San Diego. The SLAS2016 Program Committee is considering poster abstracts from life sciences discovery and technology professionals at all career stages. Submitters must be registered SLAS2016 participants. More SLAS ELN Reports: Identifying Cancer Cell Subsets and Therapeutic Responses with High-Content Single-Cell Screening SLAS     Share    Increasing drug resistance and recent cancer stem cell research have revealed a critical set of potent cancer cells that continue to wreak havoc on patients even when the majority of proliferating cells have been eliminated by effective therapies. But finding ways to better understand these cellular subsets and how they respond to treatment in individual patients remains a challenge, according to Tiffany (TJ) Chen, Ph.D., director of informatics at Cytobank and a researcher at Stanford University who speaks on the topic at SLAS2016. Chen is a finalist for the $10,000 SLAS Innovation Award. Learn more in the feature article in the SLAS Electronic Laboratory Neighborhood e-zine. More Advertisement View 50+ peer reviewed videos for 3D cell culture See how to grow and analyze spheroids in one microplate Get better accuracy and reproducibility from your automation tips Learn how to improve image capture and data quality during HCS Download a comprehensive selection guide for laboratory automation products Call for Participation: SLAS Microplate Standards Advisory Committee SLAS    Share    SLAS is looking for individuals to serve on this new committee. Approved by the American National Standards Institute (ANSI) in August 2015, the committee is charged with preparing for reaccreditation of the five ANSI SLAS standards (footprint dimensions, height dimensions, bottom outside flange dimensions, well positions and well bottom elevation) which will take place in 2017. The committee retains the ability to oversee the creation of any new standards, should the directive arise. As directed by ANSI, the committee will comprise balanced representation by manufacturers of microplates, manufacturers of instruments that utilize microplates, industrial and academic users of microplates and those with a general interest but do not fit in the other categories. If you are interested, please contact Mary Geismann. More Advertisement ROBOTIC SAMPLE HANDLING SYSTEMS Experience accelerated research and increased throughput with robotic sample loading systems and accessories from Prior Scientific. Select from our automated slide and well plate loaders, LED and metal halide fluorescence illuminators, Piezo Z stages, motorized filter wheels, high speed shutters as well as custom and OEM electromechanical and optical systems. SLAS Announces SLAS2016 On-Demand Presentations SLAS     Share    One podium presentation has been selected from each SLAS2016 scientific track to be recorded and made available on demand at SLAS.org. Presentations will become available before March 1. Dues-paying SLAS members will enjoy full ongoing access. SLAS2016 Full Conference attendees will receive limited-time access through April 2016. More Advertisement Need Help Securing Hotel Reservations for SLAS2016? SLAS    Share    At this time, the SLAS2016 official conference hotels are SOLD OUT over some dates. Information and links to other hotels located near the San Diego Convention Center is now available on the SLAS2016 website. More Advertisement AUTOMATED, REPRODUCIBLE PHOSPHOPEPTIDE ENRICHMENT New App Note! Agilent AssayMAP Sample Prep Platform Enables Reproducible Automated Phosphopeptide Enrichment. Advertisement Welcome to RAD Source Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info. Advertisement Nanodrop Low-volume Automated Pipetting The BioNex Advantage: Nanodrop Automated Pipettors are the complete high-throughput solution for low-volume, high-precision pipetting from 100nl to 500µl. Aspirate and dispense up to 16 channels with individual volume control. Valve-free fluid path assures long life and easy maintenance. Ideal for PCR template and cocktail additions, DNA normalization and assay miniaturization. 2016 ISBER Annual Meeting, April 5-8, Berlin, Germany ISBER    Share    This SLAS strategic alliance partner invites SLAS members to its 2016 Annual Meeting, Bridging the Canyon – Breaking Down Walls: Unifying Biobanking Communities to Secure our Sustainability. The 2016 International Society for Biological and Environmental Repositories Annual Meeting & Exhibits features multiple plenary sessions, educational and corporate workshops, contributed paper presentations, poster sessions and working group discussions. Vendors from around the world demonstrate the latest products, services and technology in the field of repository and specimen collection. Take advantage of the early-bird registration rate by Feb. 8, 2016, and save $200 or more on registration. More Advertisement Nanotech Weapon Against Chronic Bacterial Infections in Hospitals Science Daily    Share    Biofilms have been linked to 80% of infections, forming on living tissues or dwelling in medical devices, and cause chronic infections that are extremely resistant to antibiotics able to evade the immune system. A new nanomedicine technique offers a non-toxic way to dislodge biofilms in infected tissue, making them vulnerable to antibiotics. More CRISPR Helps Heal Mice With Muscular Dystrophy Science Magazine    Share    The red-hot genome editing tool known as CRISPR has scored another achievement: Researchers have used it to treat a severe form of muscular dystrophy in mice. Three groups report in Science that they wielded CRISPR to snip out part of a defective gene in mice with Duchenne muscular dystrophy, allowing the animals to make an essential muscle protein. The approach is the first time CRISPR has been successfully delivered throughout the body to treat grown animals with a genetic disease. More Advertisement It's All About Your Data CLICK to see why CDD Vault is the Drug Discovery Informatics platform your Project Team will embrace, allowing you to effortlessly store & mine all data. Advertisement Become a Lab Superhero! The Mantis will revolutionize your workflow for applications including NGS sample prep, qPCR, assay development, and cellular assays. Automation made simple. How New Genes Sprout From Once-Barren DNA Genetic Engineering & Biotechnology News    Share    The genome is not as static as a well-tended garden. It has its wild side. New genes emerge continuously. Some even sprout like weeds from genomic regions once devoid of functional DNA. These seemingly unlikely outgrowths needn't be copies or modified versions of existing genes. Instead, they can be entirely new, pushing evolutionary processes in new directions, especially if they become intensively cultivated — transcriptionally speaking. More Advertisement Chemists Merge 2 Fundamental Reactions to Achieve a New Cross-Coupling Scheme Chemical & Engineering News    Share    In a case of teaching an old dog a new trick, Boston College researchers have discovered how to merge two important chemical transformations involving widely used organoboron reagents into one. Liang Zhang, James P. Morken, and coworkers found they could combine key steps of the Suzuki-Miyaura cross-coupling catalytic cycle with a stoichiometric metallate rearrangement process to generate a multicomponent catalytic reaction that delivers chiral products. More Advertisement KMC Systems Engineering & Manufacturing KMC Systems provides contract engineering and manufacturing services to leading and emerging OEMs. As a trusted outsourcing partner for 35 years, KMC Systems develops, designs and manufactures cutting-edge, full-system instrumentation for the medical and life science markets. Visit us online and download our brochure to learn more about KMC Systems. Advertisement The Concept Is Simple We work with scientists to design and develop new, innovative tools for biological, chemical, and materials research, both in basic studies and pharmaceutical and industrial applications. We know research, we know assay development, and we know tools development. Learn More Advertisement Labcyte- Echo® liquid handler and Access™ workstation Learn about the latest applications of the Echo® liquid handler and Access™ workstation in qPCR and biochemical assays. With the Echo liquid handler and Access workstation you can eliminate tip costs and increase the throughput of miniaturized assays. The future of science is sound. MORE Cell-Free Protein Synthesis The Scientist    Share    Researchers from the Oak Ridge National Laboratory in Tennessee have created an artificial system to synthesize proteins without needing a cell culture. The group published its report in Small. The bioreactor uses a reagent mix that combines E. coli cell extract, DNA encoding the gene for a green fluorescent protein, and the necessary metabolites. Instead of a living system, the new protein synthesis machinery uses long serpentine channels made of silicon integrated with an artificial membrane to combine materials between a "reactor" and a "feeder" channel. More Scientists Look Deeper Into the Body With New Fluorescent Dye Phys.org    Share    Glowing dyes help scientists see inside the body and diagnose ailments, but they needed a certain type of molecule to improve the imaging depth. They invented a long wavelength near-infrared fluorescent molecule, and it works. In recent years, physicians and researchers have increasingly turned to glowing dyes to look beneath the skin. An eye doctor, for example, might inject a dye into a patient's blood before shining a bright light in her eye. More Advertisement Study Uncovers Inherited Genetic Susceptibility Across 12 Cancer Types Bioscience Technology    Share    Researchers long have known that some portion of the risk of developing cancer is hereditary and that inherited genetic errors are very important in some tumors but much less so in others. In a new analysis, researchers have shed light on these hereditary elements across 12 cancer types — showing a surprising inherited component to stomach cancer and providing some needed clarity on the consequences of certain types of mutations in well-known breast cancer susceptibility genes, BRCA1 and BRCA2. More Researchers Find Link Between Processed Foods and Autoimmune Diseases Lab Manager    Share    In today's hustle and bustle world, processed foods are commonplace time-savers. But that convenience factor may come with a bigger price tag than previously known, says an international team of researchers. In findings published in Autoimmunity Reviews, researchers from Israel and Germany present evidence that processed foods weaken the intestine's resistance to bacteria, toxins, and other hostile nutritional and not nutritional elements, which in turn increases the likelihood of developing autoimmune diseases. More Lab Automation Expert Syngenta US – NC – Raleigh Laboratory Operations Director Geisinger Health System US – PA – Scranton Director Research & Development Pacific Biomarkers US – WA – Seattle Search Jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues Dec. 30, 2015 Dec. 23, 2015 Dec. 16, 2015 Dec. 9, 2015 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063