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SLAS Discovery Kicks Off 2020 with New Tagline; Adds Additional Call for Papers
SLAS
"Advancing the Science of Drug Discovery" has replaced "Advancing Life Sciences R&D," as the official tagline of SLAS Discovery, beginning with the just-released January edition of the publication. "SLAS Discovery is a key source for articles on finding chemical and biological tools, innovation in target validation, and novel assay methods to help advance drug discovery," said SLAS Discovery Editor-in-Chief Bob Campbell, Ph.D., (Eli Lilly and Co.). "To encompass these related drug discovery fields, it was agreed upon that its original tagline, 'Advancing the Science of Drug Discovery,' was more appropriate and inclusive of the scope of topics published in today's evolution of SLAS Discovery."
READ MORE ABOUT THE NEW TAGLINE
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New Call for Papers — Advances in Protein Degradation
SLAS
SLAS Discovery Guest Editors M. Paola Castaldi, Ph.D., (AstraZeneca) and Stewart L. Fisher, Ph.D., (C4 Therapeutics, Inc.) are now accepting abstracts pertaining to protein degradation for publication in a 2021 Special Issue. More specifically, they are looking for abstracts and manuscripts covering the range of protein degradation modalities - heterobifunctional (PROTACs), "molecular glues" and ligand-induced degradation — or the scientific approaches required to identify, characterize or optimize such therapeutic agents. The deadline to submit proposals is Tuesday, March 31.
CALL FOR PAPERS FULL DETAILS
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Bonus Level: Add a Short Course at SLAS2020
SLAS
It's not too late to level up your SLAS2020 agenda with a pre-conference Short Course on Saturday or Sunday, January 25-26. Seats are still available in most courses and class size was extended for the very popular and new Streamlining your Laboratory with Python, an Introduction course. (Hurry, only eight seats left.)
VIEW SHORT COURSES
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Calendar of Important Dates
SLAS
SLAS Journal Special Issues Call for Papers
Advances in Protein Degradation – NEW!
Proposals due March 31, 2020
Early Drug Discovery Approaches with More Physiologically Relevant Targets
Proposals due: Deadline extended to March 31, 2020!
Upcoming Events
Come see SLAS at these important events:
SLAS2020 International Conference and Exhibition
January 25 – 29, 2020
San Diego, CA, USA
Call for Poster Abstracts Open
View SLAS2020 Sponsorship Opportunities
SLAS 2020 European Sample Management Symposium — Registration Now Open!
Berlin, Germany
16-17 March 2020
Poster Submission Deadline: Monday, February 10, 2020
SLAS 2020 Europe Conference and Exhibition — Now Accepting Podium and Poster Abstracts!
Vienna, Austria
2-5 June 2020
Podium Submission Deadline: Monday, February 3, 2020
Tony B. Application Deadline (Podium): Monday, February 3, 2020
Tony B. Application Deadline (Poster Only): Monday, March 2, 2020
Student Poster Submission Deadline: Monday, April 6, 2020
Final Poster Submission Deadline: Monday, April 27, 2020
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Critical Role of Tricyclic Bridges Including Neighboring Rings for Understanding Raman Spectra of Zeolites
Journal of the American Chemical Society
Raman spectroscopy of network solids such as zeolites is critical for shedding light on collective vibrations of medium-range structures such as rings that exist in crystals and that form during crystallization processes. Despite this importance, assignments of Raman spectra are not completely understood, though it is often assumed that Raman bands can be assigned to individual rings.
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For CRISPR, Tweaking DNA Fragments Before Inserting Yields Highest Efficiency Rates Yet
Science Daily
University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.
By chemically tweaking the ends of the DNA to be inserted, the new technique is up to five times more efficient than current approaches.
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Scientists Find New Way to Sustainably Make Chemicals by Copying Nature's Tricks
Phys.org
Researchers have copied the way organisms produce toxic chemicals without harming themselves, paving the way for greener chemical and fuel production.
The new technique, pioneered by Imperial College London scientists, could reduce the need to use fossil fuels to create chemicals, plastics, fibers and fuels.
Currently, many useful chemicals are produced from fossil fuels, which require mining, are of limited supply, and disrupt the carbon cycle.
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Some Genetic Sequencing Fails to Analyze Large Segments of DNA
Lab Manager
Children who undergo expansive genetic sequencing may not be getting the thorough DNA analysis their parents were expecting, say experts at UT Southwestern Medical Center.
A review of clinical tests from three major U.S. laboratories shows whole exome sequencing routinely fails to adequately analyze large segments of DNA, a potentially critical deficiency that can prevent doctors from accurately diagnosing potential genetic disorders, from epilepsy to cancer.
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Organic Synthesis by Brute Force
Chemical & Engineering News
A frustrated chemist might be tempted to whack the heck out of her compound when a synthesis just won't go to plan. For mechanochemical reactions, this kind of a smack can actually be helpful. Some reactions can use mechanical energy as an input, and in some cases, this can make organic synthesis greener by eliminating the use of less desirable solvents.
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Using a Material's 'Memory' to Encode Unique Physical Properties
Lab Manager
A new study published in Science Advances found that certain types of materials have a "memory" of how they were processed, stored, and manipulated. Researchers were then able to use this memory to control how a material ages and to encode specific properties that allow it to perform new functions. This creative approach for designing materials was the result of a collaboration between Penn's Andrea Liu and Sidney R. Nagel, Nidhi Pashine, and Daniel Hexner from the University of Chicago.
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Polio Eradication Program Faces Hard Choices as Endgame Strategy Falters
Science Magazine
The "endgame" in the decadeslong campaign to eradicate polio suffered major setbacks in 2019. While the effort lost ground in Afghanistan and Pakistan, which recorded 116 cases of wild polio — four times the number in 2018 — an especially alarming situation developed in Africa. In 12 countries, 196 children were paralyzed not by the wild virus, but by a strain derived from a live vaccine that has regained its virulence and ability to spread.
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Parkinson's Process Nipped in the RNA Bud
Genetic Engineering & Biotechnology News
A well-tended world can turn into an unweeded garden, Hamlet moaned. Tragically, he turned out to be better at moaning over "things rank and gross in nature" than at getting a grip on his predicament. Refusing to follow Hamlet's example, scientists based at Scripps Research have shown that they can get a handle on their own version of an unwelcome weed — a protein that aggregates in Lewy bodies and culminates in Parkinson's disease.
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Dog Study Revives Concerns About Virus Used for Gene Therapy
The Scientist
Adeno-associated viruses are popular vectors for delivering gene therapies to patients' cells because, researchers believed, the DNA these viruses carry rarely inserts into the host genome. But according to results presented at the American Society of Hematology meeting in Orlando, Florida, this assumption may be wrong. In six dogs that were treated with an AAV-based gene therapy for the blood-clotting disorder hemophilia B, all of them carried the therapeutic DNA within their genomes, and in some cases, the genetic material had inserted near genes known to play a role in cell growth.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Lead Automation Laboratory Technician/Assistant
The AutoFlow Group at the Novo Nordisk Foundation Center for Biosustainability
EU – Denmark – Copenhagen
Postdoctoral Research Associate - Infectious Diseases
Washington University in St. Louis
US – MO – St. Louis
Research Scientist/Engineer 4
University of Washington
US – WA – Seattle
Search Jobs at SLAS Career Connections
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